PMID- 30796939
OWN - NLM
STAT- MEDLINE
DCOM- 20190724
LR  - 20191210
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 150
DP  - 2019 Apr
TI  - Evaluation of the Finnish Diabetes Risk Score as a screening tool for undiagnosed 
      type 2 diabetes and dysglycaemia among early middle-aged adults in a large-scale 
      European cohort. The Feel4Diabetes-study.
PG  - 99-110
LID - S0168-8227(18)31723-6 [pii]
LID - 10.1016/j.diabres.2019.02.017 [doi]
AB  - AIM: To assess the diagnostic accuracy of the FINDRISC for undiagnosed type 2 
      diabetes mellitus (T2DM) and dysglycaemia (i.e. the presence of prediabetes or 
      T2DM) among early middle-aged adults from vulnerable groups in a large-scale 
      European cohort. METHODS: Participants were recruited from low-socioeconomic 
      areas in high-income countries (HICs) (Belgium-Finland) and in HICs under 
      austerity measures (Greece-Spain) and from the overall population in 
      low/middle-income countries (LMICs) (Bulgaria-Hungary). Study population 
      comprised of 2116 parents of primary-school children from families identified at 
      increased risk of T2DM, based on parental self-reported FINDRISC. Sensitivity 
      (Se), specificity (Sp), area under the receiver operating characteristic curves 
      (AUC-ROC) and the optimal cut-offs of FINDRISC that indicate an increased 
      probability for undiagnosed T2DM or dysglycaemia were calculated. RESULTS: The 
      AUC-ROC for undiagnosed T2DM was 0.824 with optimal cut-off >/=14 (Se = 68%, 
      Sp = 81.7%) for the total sample, 0.839 with optimal cut-off >/=15 (Se = 83.3%, 
      Sp = 86.9%) for HICs, 0.794 with optimal cut-off >/=12 (Se = 83.3%, Sp = 61.1%) for 
      HICs under austerity measures and 0.882 with optimal cut-off >/=14 (Se = 71.4%, 
      Sp = 87.8%) for LMICs. The AUC-ROC for dysglycaemia was 0.663 with optimal 
      cut-off >/=12 (Se = 58.3%, Sp = 65.7%) for the total sample, 0.656 with optimal 
      cut-off >/=12 (Se = 54.5%, Sp = 64.8%) for HICs, 0.631 with optimal cut-off >/=12 
      (Se = 59.7%, Sp = 62.0%) for HICs under austerity measures and 0.735 with optimal 
      cut-off >/=11 (Se = 72.7%, Sp = 70.2%) for LMICs. CONCLUSION: FINDRISC can be 
      applied for screening primarily undiagnosed T2DM but also dysglycaemia among 
      vulnerable groups across Europe, considering the use of different cut-offs for 
      each subpopulation.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Mavrogianni, Christina
AU  - Mavrogianni C
AD  - Department of Nutrition and Dietetics, School of Health Science and Education, 
      Harokopio University, Athens, Greece.
FAU - Lambrinou, Christina-Paulina
AU  - Lambrinou CP
AD  - Department of Nutrition and Dietetics, School of Health Science and Education, 
      Harokopio University, Athens, Greece.
FAU - Androutsos, Odysseas
AU  - Androutsos O
AD  - Department of Nutrition and Dietetics, School of Health Science and Education, 
      Harokopio University, Athens, Greece.
FAU - Lindstrom, Jaana
AU  - Lindstrom J
AD  - National Institute for Health and Welfare, Helsinki, Finland.
FAU - Kivela, Jemina
AU  - Kivela J
AD  - National Institute for Health and Welfare, Helsinki, Finland.
FAU - Cardon, Greet
AU  - Cardon G
AD  - Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium.
FAU - Huys, Nele
AU  - Huys N
AD  - Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium.
FAU - Tsochev, Kaloyan
AU  - Tsochev K
AD  - Department of Pediatrics, Medical University Varna, Varna, Bulgaria.
FAU - Iotova, Violeta
AU  - Iotova V
AD  - Department of Pediatrics, Medical University Varna, Varna, Bulgaria.
FAU - Chakarova, Nevena
AU  - Chakarova N
AD  - Department of Diabetology, Clinical Center of Endocrinology, Medical University 
      Sofia, Sofia, Bulgaria.
FAU - Rurik, Imre
AU  - Rurik I
AD  - Department of Family and Occupational Medicine, University of Debrecen, Debrecen, 
      Hungary.
FAU - Moreno, Luis A
AU  - Moreno LA
AD  - GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of 
      Zaragoza, Zaragoza, Spain.
FAU - Liatis, Stavros
AU  - Liatis S
AD  - First Department of Propaedeutic Internal Medicine, Medical School, National and 
      Kapodistrian University of Athens, Athens, Greece.
FAU - Makrilakis, Konstantinos
AU  - Makrilakis K
AD  - First Department of Propaedeutic Internal Medicine, Medical School, National and 
      Kapodistrian University of Athens, Athens, Greece.
FAU - Manios, Yannis
AU  - Manios Y
AD  - Department of Nutrition and Dietetics, School of Health Science and Education, 
      Harokopio University, Athens, Greece. Electronic address: manios@hua.gr.
CN  - Feel4Diabetes-study group
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20190220
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
MH  - Adult
MH  - Child
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*diagnosis/*epidemiology
MH  - Europe/epidemiology
MH  - Female
MH  - Finland
MH  - Humans
MH  - Male
MH  - *Mass Screening
MH  - Middle Aged
MH  - Prediabetic State/*diagnosis/*epidemiology
MH  - ROC Curve
MH  - Risk Factors
OTO - NOTNLM
OT  - Diabetes prevention
OT  - Diabetes screening
OT  - FINDRISC
OT  - Type 2 diabetes mellitus
OT  - Vulnerable groups
EDAT- 2019/02/24 06:00
MHDA- 2019/07/25 06:00
CRDT- 2019/02/24 06:00
PHST- 2018/11/22 00:00 [received]
PHST- 2019/01/31 00:00 [revised]
PHST- 2019/02/18 00:00 [accepted]
PHST- 2019/02/24 06:00 [pubmed]
PHST- 2019/07/25 06:00 [medline]
PHST- 2019/02/24 06:00 [entrez]
AID - S0168-8227(18)31723-6 [pii]
AID - 10.1016/j.diabres.2019.02.017 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2019 Apr;150:99-110. doi: 10.1016/j.diabres.2019.02.017. 
      Epub 2019 Feb 20.