PMID- 30797024
OWN - NLM
STAT- MEDLINE
DCOM- 20200102
LR  - 20200102
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 406
DP  - 2019 May 15
TI  - Prenatal immune challenge induces behavioral deficits, neuronal remodeling, and 
      increases brain nitric oxide and zinc levels in the male rat offspring.
PG  - 594-605
LID - S0306-4522(19)30120-4 [pii]
LID - 10.1016/j.neuroscience.2019.02.018 [doi]
AB  - Schizophrenia is a severe mental disorder with numerous etiological 
      susceptibilities. Maternal infection is a key risk factor for schizophrenia. 
      Prenatal lipopolysaccharide (LPS) infection stimulates cytokine production that 
      affects brain development. In the present study, we aimed to investigate the 
      effect of prenatal LPS injection at gestational day (GD) 14-16 on behavioral 
      paradigms, and neuronal morphology in the prefrontal cortex (PFC), basolateral 
      amygdala (BLA), nucleus accumbens (NAcc) and ventral hippocampus (VH) at two 
      critical ages of development: pre-pubertal (postnatal day 35, PD35) and 
      post-pubertal (PD60) age in male rats. We also evaluated the effects of LPS on 
      nitric oxide (NO) and zinc (Zn) levels in seven brain areas (PFC, VH, amygdala, 
      brainstem, striatum and dorsal hippocampus) at PD35 and PD60. LPS induced 
      hyperlocomotion in a novel environment and reduced social contact as well as 
      increased the levels of NO and Zn in the PFC, brainstem and amygdala as observed 
      in other animal models of schizophrenia-related behavior. Furthermore, we found 
      that LPS-treated rats presented post-pubertal neuronal hypertrophy in the PFC and 
      BLA and decreased spine density in the NAcc. The neuronal morphology of neurons 
      in the VH in LPS-treated rats remained unaltered. Interestingly, the 
      anxiogenic-related behavior correlated with neuronal hypertrophy observed in the 
      BLA. Our findings suggest that the behavioral and neural modifications observed 
      in our model could be mediated by the long-lasting alterations in Zn and NO 
      levels in the brain.
CI  - Copyright (c) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Tellez-Merlo, Guillermina
AU  - Tellez-Merlo G
AD  - Lab. Neuropsiquiatria, Instituto de Fisiologia, Benemerita Universidad Autonoma 
      de Puebla, 14 Sur 6301, San Manuel, 72570, Puebla, Mexico; Departamento de 
      Fisiologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico 
      Nacional, Ciudad de Mexico, Mexico.
FAU - Morales-Medina, Julio Cesar
AU  - Morales-Medina JC
AD  - Centro de Investigacion en Reproduccion Animal, CINVESTAV- Universidad Autonoma 
      de Tlaxcala, AP 62, CP 90000, Tlaxcala, Mexico.
FAU - Camacho-Abrego, Israel
AU  - Camacho-Abrego I
AD  - Lab. Neuropsiquiatria, Instituto de Fisiologia, Benemerita Universidad Autonoma 
      de Puebla, 14 Sur 6301, San Manuel, 72570, Puebla, Mexico.
FAU - Juarez-Diaz, Ismael
AU  - Juarez-Diaz I
AD  - Depto. Fisiologia, Facultad de Estomatologia, Benemerita Universidad Autonoma de 
      Puebla, Puebla, Mexico.
FAU - Aguilar-Alonso, Patricia
AU  - Aguilar-Alonso P
AD  - Facultad de Ciencias Quimicas, Benemerita Universidad Autonoma de Puebla, Puebla, 
      Mexico.
FAU - de la Cruz, Fidel
AU  - de la Cruz F
AD  - Departamento de Fisiologia, Escuela Nacional de Ciencias Biologicas, Instituto 
      Politecnico Nacional, Ciudad de Mexico, Mexico.
FAU - Iannitti, Tommaso
AU  - Iannitti T
AD  - KWS BioTest, Marine View Office Park, Portishead, Somerset BS20 7AW, UK.
FAU - Flores, Gonzalo
AU  - Flores G
AD  - Lab. Neuropsiquiatria, Instituto de Fisiologia, Benemerita Universidad Autonoma 
      de Puebla, 14 Sur 6301, San Manuel, 72570, Puebla, Mexico. Electronic address: 
      gonzalo.flores@correo.buap.mx.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190221
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Lipopolysaccharides)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Amygdala/drug effects
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/*drug effects/immunology
MH  - Central Nervous System Stimulants/pharmacology
MH  - Female
MH  - Hippocampus/drug effects/metabolism
MH  - Lipopolysaccharides/*pharmacology
MH  - Male
MH  - Motor Activity/drug effects
MH  - Neuronal Plasticity/*drug effects/immunology
MH  - Nitric Oxide/*metabolism
MH  - Nucleus Accumbens/drug effects/immunology
MH  - Prefrontal Cortex/drug effects/immunology
MH  - Rats, Sprague-Dawley
MH  - Zinc/*metabolism
OTO - NOTNLM
OT  - Golgi-Cox staining
OT  - amygdala
OT  - anxiety
OT  - maternal infection
OT  - schizophrenia
EDAT- 2019/02/24 06:00
MHDA- 2020/01/03 06:00
CRDT- 2019/02/24 06:00
PHST- 2018/08/11 00:00 [received]
PHST- 2018/12/11 00:00 [revised]
PHST- 2019/02/12 00:00 [accepted]
PHST- 2019/02/24 06:00 [pubmed]
PHST- 2020/01/03 06:00 [medline]
PHST- 2019/02/24 06:00 [entrez]
AID - S0306-4522(19)30120-4 [pii]
AID - 10.1016/j.neuroscience.2019.02.018 [doi]
PST - ppublish
SO  - Neuroscience. 2019 May 15;406:594-605. doi: 10.1016/j.neuroscience.2019.02.018. 
      Epub 2019 Feb 21.