PMID- 30798107
OWN - NLM
STAT- MEDLINE
DCOM- 20200618
LR  - 20200618
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 399
DP  - 2019 Apr 15
TI  - Low-contrast visual evoked potential and early detection of optic demyelination.
PG  - 108-110
LID - S0022-510X(19)30076-0 [pii]
LID - 10.1016/j.jns.2019.02.015 [doi]
AB  - Visual Evoked Potential (VEP) is a useful tool in identifying abnormality 
      relative to the integration of optic pathways, and aids the diagnosis of central 
      nervous system demyelinating disorders, such as multiple sclerosis (MS). However, 
      the sensitivity of VEP in detecting early optic abnormality as a visual function 
      surrogate remains questionable. Recent studies showed that low-contrast VEP 
      increases sensitivity in early detection of optic demyelination. In order to 
      evaluate the applicability of low-contrast VEP to our electrodiagnostic protocol, 
      we tested whether low-contrast VEP may provide an improved sensitivity in 
      identifying early optic demyelination. We performed low-contrast VEP with 
      different stimulation intensities in 42 subjects. Twenty-three were patients 
      (age: 44.0 +/- 13.6 year-old, range 26-69) with a clinical diagnosis of clinically 
      isolated syndrome, a subtype of MS, and 19 subjects were normal volunteers (age: 
      34.4 +/- 14.3 year-old, range: 18-59) without any neurological disorders. Neither 
      of them had a history of optic neuritis. Our preliminary data indicate that the 
      low-contrast VEP is not superior over the conventional high-contrast VEP, and may 
      not provide improved sensitivity in early detection of optic demyelination.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Luo, Jin Jun
AU  - Luo JJ
AD  - Department of Neurology, Lewis Katz School of Medicine at Temple University, 
      Philadelphia, PA 19140, USA; Department of Pharmacology, Lewis Katz School of 
      Medicine at Temple University, Philadelphia, PA 19140, USA. Electronic address: 
      jluo@temple.edu.
FAU - Bumanlag, Favio
AU  - Bumanlag F
AD  - Department of Neurology, Lewis Katz School of Medicine at Temple University, 
      Philadelphia, PA 19140, USA.
FAU - Dun, Nae
AU  - Dun N
AD  - Department of Pharmacology, Lewis Katz School of Medicine at Temple University, 
      Philadelphia, PA 19140, USA.
LA  - eng
PT  - Journal Article
DEP - 20190210
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Demyelinating Diseases/*diagnosis/physiopathology
MH  - Early Diagnosis
MH  - Electroencephalography
MH  - Evoked Potentials, Visual/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnosis/physiopathology
MH  - Neurologic Examination
MH  - Optic Neuritis/*diagnosis/physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Early diagnosis
OT  - Multiple sclerosis
OT  - Visual evoked potential
EDAT- 2019/02/25 06:00
MHDA- 2020/06/19 06:00
CRDT- 2019/02/25 06:00
PHST- 2018/11/24 00:00 [received]
PHST- 2019/02/06 00:00 [revised]
PHST- 2019/02/08 00:00 [accepted]
PHST- 2019/02/25 06:00 [pubmed]
PHST- 2020/06/19 06:00 [medline]
PHST- 2019/02/25 06:00 [entrez]
AID - S0022-510X(19)30076-0 [pii]
AID - 10.1016/j.jns.2019.02.015 [doi]
PST - ppublish
SO  - J Neurol Sci. 2019 Apr 15;399:108-110. doi: 10.1016/j.jns.2019.02.015. Epub 2019 
      Feb 10.