PMID- 3079892
OWN - NLM
STAT- MEDLINE
DCOM- 19860220
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 42
IP  - 1
DP  - 1986
TI  - Inhibition of gonadotropin secretion induced by cholecystokinin implants in the 
      medial preoptic area by the dopamine receptor blocker, pimozide, in the rat.
PG  - 32-7
AB  - We have shown that the implantation of cholecystokinin octapeptide sulfated form 
      (CCK-8-S) or dopamine (DA) in the medial preoptic area (MPO) in ovariectomized 
      estrogen-primed rats induced an enhancement of the afternoon rise in LH 
      secretion. The present study was done to examine the possible functional 
      interaction of both substances in the brain. Two groups of ovariectomized 
      estradiol (5 micrograms, s.c.)-primed rats were administered intraperitoneally 
      either pimozide (1 mg/kg BW; pimozide-treated group) or 0.1 M tartaric acid as 
      the control solution (pimozide-untreated group). CCK-8-S or DA was implanted in 
      the MPO through chronically implanted guide cannulae and the effects on serum LH 
      and FSH concentrations were compared between both groups. An empty cannula was 
      used as the control. Implantation of either CCK-8-S or DA in the 
      pimozide-untreated group induced marked enhancements of afternoon rises in LH and 
      FSH levels, which normally occurred, but with a lesser magnitude in the animals 
      with the empty cannula. In the pimozide-treated group, however, neither CCK-8-S 
      nor DA induced changes in the LH and FSH levels. It was evident that both effects 
      of CCK-8-S and DA on LH and FSH secretion were blocked by pretreatment with the 
      DA receptor blocker. These data indicate that DA receptors are required to be 
      intact when CCK-8-S implants manifest their action in stimulating gonadotropin 
      secretion.
FAU - Hashimoto, R
AU  - Hashimoto R
FAU - Kimura, F
AU  - Kimura F
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Drug Implants)
RN  - 0 (Receptors, Dopamine)
RN  - 1HIZ4DL86F (Pimozide)
RN  - 4TI98Z838E (Estradiol)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - M03GIQ7Z6P (Sincalide)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain Chemistry/drug effects
MH  - Circadian Rhythm/drug effects
MH  - Dopamine/administration & dosage
MH  - Drug Implants
MH  - Estradiol/administration & dosage
MH  - Female
MH  - Follicle Stimulating Hormone/blood/*metabolism
MH  - Luteinizing Hormone/blood/*metabolism
MH  - Ovariectomy
MH  - Pimozide/*pharmacology
MH  - Preoptic Area/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Dopamine/*drug effects
MH  - Sincalide/*administration & dosage
MH  - Time Factors
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1159/000124245 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1986;42(1):32-7. doi: 10.1159/000124245.