PMID- 30799924 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220331 IS - 1176-6336 (Print) IS - 1178-203X (Electronic) IS - 1176-6336 (Linking) VI - 15 DP - 2019 TI - Impact of ST-segment elevation on the outcome of Takotsubo syndrome. PG - 251-258 LID - 10.2147/TCRM.S180170 [doi] AB - BACKGROUND: Recent studies have highlighted that Takotsubo syndrome (TTS), mimicking acute coronary syndrome (ACS), is associated with poor clinical outcome. TTS is associated with different repolarization disorders including ST-segment elevation. ST elevation myocardial infarction (STEMI) in ACS is associated with declined prognosis. However, the clinical and prognostic impact of ST-segment elevation on TTS remains lacking. AIM: The aim of this study was to determine the short- and long-term prognostic impact of ST-segment elevation on TTS patients as compared with STEMI patients. PATIENTS AND METHODS: Our institutional database constituted a consecutive cohort of 138 TTS patients and 138 ACS patients matched for age and sex. TTS patients (n=41) with ST-segment elevation were compared with ACS patients with ST-segment elevation (n=64). RESULTS: Chest pain was significantly more documented in STEMI patients as compared with TTS patients (48.8% vs 78.1%; P<0.01). Cardiovascular risk factors such as diabetes mellitus (12.2% vs 29.7%; P=0.02) were significantly more presented in STEMI patients. Although the initial left ventricular ejection fraction (LVEF) was more declined in TTS patients (39%+/-9% vs 45%+/-16%; P<0.01), the LVEF was more declined in STEMI patients at follow-up (54%+/-10% vs 45%+/-16%; P=0.04). Inhospital complications such as respiratory failure were significantly more presented in TTS patients (68.3% vs 20.3%; P<0.01). The short-term as well as the long-term morality was similar in both groups. In univariate analysis, male sex, ejection fraction (EF) <35%, glomerular filtration rate (GFR) <60 mL/min, cardiogenic shock, inotropic drugs, and history of cancer were predictors of 5-year mortality. CONCLUSION: Rates of the long-term mortality in TTS patients with ST elevations are comparable with STEMI patients. FAU - Gietzen, Thorsten AU - Gietzen T AD - First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. AD - German Center for Cardiovascular Research (DZHK), Partner Site, Heidelberg-Mannheim, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. FAU - El-Battrawy, Ibrahim AU - El-Battrawy I AD - First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. AD - German Center for Cardiovascular Research (DZHK), Partner Site, Heidelberg-Mannheim, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. FAU - Lang, Siegfried AU - Lang S AD - First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. AD - German Center for Cardiovascular Research (DZHK), Partner Site, Heidelberg-Mannheim, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. FAU - Zhou, Xiao-Bo AU - Zhou XB AD - First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. AD - German Center for Cardiovascular Research (DZHK), Partner Site, Heidelberg-Mannheim, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. FAU - Behnes, Michael AU - Behnes M AD - First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. FAU - Ansari, Uzair AU - Ansari U AD - First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. FAU - Borggrefe, Martin AU - Borggrefe M AD - First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. AD - German Center for Cardiovascular Research (DZHK), Partner Site, Heidelberg-Mannheim, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. FAU - Akin, Ibrahim AU - Akin I AD - First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. AD - German Center for Cardiovascular Research (DZHK), Partner Site, Heidelberg-Mannheim, Mannheim, Germany, ibrahim.el-battrawy@medma.uni-heidelberg.de. LA - eng PT - Journal Article DEP - 20190207 PL - New Zealand TA - Ther Clin Risk Manag JT - Therapeutics and clinical risk management JID - 101253281 PMC - PMC6369855 OTO - NOTNLM OT - ST elevation OT - Takotsubo syndrome OT - coronary artery syndrome OT - prognosis COIS- Disclosure The authors report no conflicts of interest in this work. EDAT- 2019/02/26 06:00 MHDA- 2019/02/26 06:01 PMCR- 2019/02/07 CRDT- 2019/02/26 06:00 PHST- 2019/02/26 06:00 [entrez] PHST- 2019/02/26 06:00 [pubmed] PHST- 2019/02/26 06:01 [medline] PHST- 2019/02/07 00:00 [pmc-release] AID - tcrm-15-251 [pii] AID - 10.2147/TCRM.S180170 [doi] PST - epublish SO - Ther Clin Risk Manag. 2019 Feb 7;15:251-258. doi: 10.2147/TCRM.S180170. eCollection 2019.