PMID- 30800058
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 13
DP  - 2019
TI  - Resveratrol Improves Brain-Gut Axis by Regulation of 5-HT-Dependent Signaling in 
      the Rat Model of Irritable Bowel Syndrome.
PG  - 30
LID - 10.3389/fncel.2019.00030 [doi]
LID - 30
AB  - Irritable bowel syndrome (IBS) is at high risk of co-morbid depression and 
      anxiety, which reduces patients' quality of life and increases the burden of 
      health care costs. However, the pathophysiological mechanisms responsible for IBS 
      still remain unknown. This study investigated the effects of resveratrol on 
      stress-related depression, anxiety, intestinal and visceral dysfunction in rat 
      model of IBS. Rats received chronic acute combining stress (CACS) for 22 days 
      exhibited depression/anxiety-like behavior, visceral hypersensitivity and altered 
      intestinal motility, as measured by the forced swimming, marble bury, abdominal 
      withdrawal reflex (AWR) and intestinal tract motility (ITM) tests. These 
      abnormalities were accompanied by reduced 5-hydroxytryptamine (5-HT) level in the 
      hippocampus and increased 5-HT expression in the gut (ileum and colon) after 
      CACS. Chronic treatment of IBS rats with resveratrol dose-dependently normalized 
      CACS-induced both central nervous and peripheral dysfunction, which were 
      consistent with its differentially regulating 5-HT contents in the brain and 
      intestine. Pretreatment with the 5-HT(1A) receptor antagonist NAN-190 
      hydrobromide (NAN-190) prevented such effects. While sub-threshold of 5-HT(1A) 
      receptor agonist 8-OH-DPAT potentiated the effects of low dose of resveratrol (10 
      mg/kg) on CACS-related behavioral abnormalities. Furthermore, resveratrol 
      markedly increased PKA, p-cAMP-response element binding protein (p-CREB) and 
      brain derived neurotrophic factor (BDNF) expression in the hippocampus of IBS 
      rats, while decreased PKA, pCREB and BDNF levels were found in the ileum and 
      colon. These effects were prevented by NAN-190, which were consistent with the 
      behavioral changes. The present results suggested that resveratrol improved 
      anti-IBS-like effects on depression, anxiety, visceral hypersensitivity and 
      intestinal motility abnormality through regulating 5-HT(1A)-dependent 
      PKA-CREB-BDNF signaling in the brain-gut axis.
FAU - Yu, Ying-Cong
AU  - Yu YC
AD  - Department of Gastroenterology, Wenzhou No. 3 Clinical Institute Affiliated to 
      Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, China.
AD  - Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Zhang, Meixi
AU  - Zhang M
AD  - Pingyang Hospital of Traditional Chinese Medicine, Pingyang, China.
FAU - Pan, Jian-Chun
AU  - Pan JC
AD  - Brain Institute, School of Pharmacy, Wenzhou Medical University, Wenzhou, China.
FAU - Yu, Ying
AU  - Yu Y
AD  - Department of Gastroenterology, Wenzhou No. 3 Clinical Institute Affiliated to 
      Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, China.
FAU - Zhang, Jian-Bo
AU  - Zhang JB
AD  - Brain Institute, School of Pharmacy, Wenzhou Medical University, Wenzhou, China.
FAU - Zheng, Liang
AU  - Zheng L
AD  - Department of Gastroenterology, Wenzhou No. 3 Clinical Institute Affiliated to 
      Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, China.
FAU - Si, Jian-Min
AU  - Si JM
AD  - Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
FAU - Xu, Ying
AU  - Xu Y
AD  - Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical 
      Sciences, University at Buffalo, The State University of New York, Buffalo, NY, 
      United States.
LA  - eng
PT  - Journal Article
DEP - 20190208
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC6375832
OTO - NOTNLM
OT  - 5-HT
OT  - BDNF
OT  - chronic acute combining stress
OT  - irritable bowel syndrome
OT  - pCREB
EDAT- 2019/02/26 06:00
MHDA- 2019/02/26 06:01
PMCR- 2019/01/01
CRDT- 2019/02/26 06:00
PHST- 2018/10/11 00:00 [received]
PHST- 2019/01/22 00:00 [accepted]
PHST- 2019/02/26 06:00 [entrez]
PHST- 2019/02/26 06:00 [pubmed]
PHST- 2019/02/26 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2019.00030 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2019 Feb 8;13:30. doi: 10.3389/fncel.2019.00030. eCollection 
      2019.