PMID- 30800149
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1671-5411 (Print)
IS  - 1671-5411 (Linking)
VI  - 16
IP  - 1
DP  - 2019 Jan
TI  - Clinical, sonographic characteristics and long-term prognosis of valvular heart 
      disease in elderly patients.
PG  - 33-41
LID - 10.11909/j.issn.1671-5411.2019.01.007 [doi]
AB  - BACKGROUND: Valvular heart disease (VHD) is expected to become more prevail as 
      the population ages and disproportionately affects older adults. However, direct 
      comparison of clinical characteristics, sonographic diagnosis, and outcomes in 
      VHD patients aged over 65 years is scarce. The objective of this study was to 
      evaluate the differences in clinical characteristics and prognosis in two 
      age-groups of geriatric patients with VHD. METHODS: We retrospectively enrolled 
      consecutive individuals aged >/= 65 years from Guangdong Provincial People's 
      Hospital and screened for VHD using transthoracic echocardiography (TTE) or 
      transesophageal echocardiography (TEE). Finally, 260 (48.9%) patients were in the 
      65-74 years group, and 272 (51.1%) were in the >/= 75-year group. Factors that 
      affected long-term survival was explored. A multivariable Cox hazards regression 
      was performed to identify the predictors of major adverse cardiac events (MACEs) 
      in each group. RESULTS: In our population, the older group were more likely to 
      have chronic obstructive pulmonary disease (COPD), degenerative VHD, but with 
      less rheumatic VHD, aortic stenosis (AS) and mitral stenosis (MS). Compared with 
      those aged 65-74 years, the older group had a higher incidence of all-cause death 
      (10.0% vs. 16.5%, P = 0.027), ischemic stroke (13.5% vs. 20.2%, P = 0.038) and 
      MACEs (37.3% vs. 48.2%, P = 0.011) at long-term follow-up. In multivariable Cox 
      regression analysis, mitral regurgitation, a history of COPD, chronic kidney 
      disease, diabetes, hypertension, atrial fibrillation and New York Heart 
      Association (NYHA) functional class were identified as independent predictors of 
      MACEs in the older group. CONCLUSION: Advanced age profoundly affect prognosis 
      and different predictors were associated with MACEs in geriatric patients with 
      VHD.
FAU - Song, Feier
AU  - Song F
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
FAU - Liu, Fang-Zhou
AU  - Liu FZ
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
FAU - Liang, Yuan-Feng
AU  - Liang YF
AD  - Guangdong Geriatric Institute, Guangdong Provincial People's Hospital and 
      Guangdong Academy of Medical Sciences, Guangzhou, China.
FAU - Tse, Gary
AU  - Tse G
AD  - Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University 
      of Hong Kong, Hong Kong, China.
AD  - Institute of Health Sciences, Faculty of Medicine, Chinese University of Hong 
      Kong, Hong Kong, China.
FAU - Li, Xin
AU  - Li X
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
FAU - Liao, Hong-Tao
AU  - Liao HT
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
FAU - Chen, Ji-Yan
AU  - Chen JY
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Geriatr Cardiol
JT  - Journal of geriatric cardiology : JGC
JID - 101237881
PMC - PMC6379235
OTO - NOTNLM
OT  - Echocardiography
OT  - Geriatrics
OT  - Mortality
OT  - Prognosis
OT  - The aged
OT  - Valvular heart disease
EDAT- 2019/02/26 06:00
MHDA- 2019/02/26 06:01
PMCR- 2019/01/01
CRDT- 2019/02/26 06:00
PHST- 2019/02/26 06:00 [entrez]
PHST- 2019/02/26 06:00 [pubmed]
PHST- 2019/02/26 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - jgc-16-01-033 [pii]
AID - 10.11909/j.issn.1671-5411.2019.01.007 [doi]
PST - ppublish
SO  - J Geriatr Cardiol. 2019 Jan;16(1):33-41. doi: 
      10.11909/j.issn.1671-5411.2019.01.007.