PMID- 30805369
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20221207
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2019
DP  - 2019
TI  - Relationships of SLC2A4, RBP4, PCK1, and PI3K Gene Polymorphisms with Gestational 
      Diabetes Mellitus in a Chinese Population.
PG  - 7398063
LID - 10.1155/2019/7398063 [doi]
LID - 7398063
AB  - BACKGROUND: Solute carrier family 2 member 4- (SLC2A4-) retinol binding 
      protein-4- (RBP4-) phosphoenolpyruvate carboxykinase 1 (PCK1)/phosphoinositide 
      3-kinase (PI3K) is an adipocyte derived "signalling pathway" that may contribute 
      to the pathogenesis of type 2 diabetes mellitus (T2DM). We explored whether 
      single nucleotide polymorphisms (SNPs) of these "signalling pathway" genes are 
      associated with gestational diabetes mellitus (GDM). METHODS: Case-control 
      studies were conducted to compare GDM and control groups. A total of 334 cases 
      and 367 controls were recruited. Seventeen candidate SNPs of the pathway were 
      selected. Chi-square tests, logistic regression, and linear regression were used 
      to estimate the relationships of SNPs with GDM risk and oral glucose tolerance 
      test (OGTT), fasting insulin, and homeostasis model assessment of insulin 
      resistance (HOMA-IR) levels. Model-based multifactor dimensionality reduction was 
      used to estimate the adjusted interactions between genes. Regression and 
      interaction analyses were adjusted by maternal age, prepregnancy BMI, and weekly 
      BMI growth. The Bonferroni correction was applied for multiple comparisons. 
      RESULTS: RBP4 rs7091052 was significantly associated with GDM risk. SLC2A4 
      rs5435, RBP4 rs7091052, PCK1 rs1042531 and rs2236745, and PIK3R1 (coding gene of 
      the PI3K P85 subunit) rs34309 were associated with OGTT, fasting insulin, and 
      HOMA-IR levels in the linear regression analysis. The gene-gene interaction 
      analysis showed that, compared with pregnant women with other genotype 
      combinations, women with SLC2A4 rs5435 (CC/CT), RBP4 rs7091052 (CC), PCK1 
      rs1042531 (TT/TG) and rs2236745 (TT), and PIK3R1 rs34309 (AA) had lower GDM risk. 
      CONCLUSION: SLC2A4, RBP4, PCK1, and PIK3R1 genes may be involved in the 
      pathogenesis of GDM.
FAU - Hu, Shimin
AU  - Hu S
AUID- ORCID: 0000-0002-3284-2494
AD  - School of Public Health, Central South University, 90 Xiangya Road, Changsha, 
      Hunan, China.
FAU - Ma, Shujuan
AU  - Ma S
AD  - School of Public Health, Central South University, 90 Xiangya Road, Changsha, 
      Hunan, China.
FAU - Li, Xun
AU  - Li X
AD  - Department of Obstetrics and Gynecology, Xiangya Hospital of Central South 
      University, 87 Xiangya Road, Changsha, Hunan, China.
FAU - Tian, Zhengwen
AU  - Tian Z
AD  - School of Public Health, Central South University, 90 Xiangya Road, Changsha, 
      Hunan, China.
FAU - Liang, Huiling
AU  - Liang H
AD  - School of Public Health, Central South University, 90 Xiangya Road, Changsha, 
      Hunan, China.
FAU - Yan, Junxia
AU  - Yan J
AD  - School of Public Health, Central South University, 90 Xiangya Road, Changsha, 
      Hunan, China.
FAU - Chen, Mengshi
AU  - Chen M
AD  - School of Public Health, Central South University, 90 Xiangya Road, Changsha, 
      Hunan, China.
FAU - Tan, Hongzhuan
AU  - Tan H
AUID- ORCID: 0000-0002-4292-5947
AD  - School of Public Health, Central South University, 90 Xiangya Road, Changsha, 
      Hunan, China.
LA  - eng
PT  - Journal Article
DEP - 20190120
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Blood Glucose)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Insulin)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (RBP4 protein, human)
RN  - 0 (Retinol-Binding Proteins, Plasma)
RN  - 0 (SLC2A4 protein, human)
RN  - EC 4.1.1.32 (PCK1 protein, human)
RN  - EC 4.1.1.32 (Phosphoenolpyruvate Carboxykinase (GTP))
SB  - IM
MH  - Adult
MH  - Asian People/*genetics
MH  - Blood Glucose/genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/genetics
MH  - Diabetes, Gestational/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Glucose Transporter Type 4/*genetics
MH  - Humans
MH  - Insulin/genetics
MH  - Insulin Resistance/genetics
MH  - Intracellular Signaling Peptides and Proteins/*genetics
MH  - Phosphatidylinositol 3-Kinases/*genetics
MH  - Phosphoenolpyruvate Carboxykinase (GTP)/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Pregnancy
MH  - Retinol-Binding Proteins, Plasma/*genetics
MH  - Signal Transduction/genetics
PMC - PMC6363241
EDAT- 2019/02/26 06:00
MHDA- 2019/06/14 06:00
PMCR- 2019/01/20
CRDT- 2019/02/27 06:00
PHST- 2018/10/09 00:00 [received]
PHST- 2019/01/02 00:00 [accepted]
PHST- 2019/02/27 06:00 [entrez]
PHST- 2019/02/26 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/01/20 00:00 [pmc-release]
AID - 10.1155/2019/7398063 [doi]
PST - epublish
SO  - Biomed Res Int. 2019 Jan 20;2019:7398063. doi: 10.1155/2019/7398063. eCollection 
      2019.