PMID- 30806245
OWN - NLM
STAT- MEDLINE
DCOM- 20190919
LR  - 20200309
IS  - 1040-8401 (Print)
IS  - 1040-8401 (Linking)
VI  - 38
IP  - 4
DP  - 2018
TI  - Airway Macrophage and Dendritic Cell Subsets in the Resting Human Lung.
PG  - 303-331
LID - 10.1615/CritRevImmunol.2018026459 [doi]
AB  - Dendritic cells (DCs) and macrophages (MPhis) are antigen-presenting phagocytic 
      cells found in many peripheral tissues of the human body, including the blood, 
      lymph nodes, skin, and lung. They are vital to maintaining steady-state 
      respiration in the human lung based on their ability to clear airways while also 
      directing tolerogenic or inflammatory responses based on specific stimuli. Over 
      the past three decades, studies have determined that there are multiple subsets 
      of these two general cell types that exist in the airways and interstitium. 
      Identifying these numerous subsets has proven challenging, especially with the 
      unique microenvironments present in the lung. Cells found in the vasculature are 
      not the same subsets found in the skin or the lung, as demonstrated by surface 
      marker expression. By transcriptional profiling, these subsets show similarities 
      but also major differences. Primary human lung cells and/ or tissues are 
      difficult to acquire, particularly in a healthy condition. Additionally, surface 
      marker screening and transcriptional profiling are continually identifying new DC 
      and MPhi subsets. While the overall field is moving forward, we emphasize that more 
      attention needs to focus on replicating the steady-state microenvironment of the 
      lung to reveal the physiological functions of these subsets.
FAU - Patel, Vineet Indrajit
AU  - Patel VI
AD  - Pulmonary and Critical Care Division of the Department of Medicine, University of 
      Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
FAU - Metcalf, Jordan Patrick
AU  - Metcalf JP
AD  - Pulmonary and Critical Care Division of the Department of Medicine and Department 
      of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 
      Oklahoma City, Oklahoma.
LA  - eng
GR  - I01 BX001937/BX/BLRD VA/United States
GR  - U19 AI062629/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Crit Rev Immunol
JT  - Critical reviews in immunology
JID - 8914819
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*cytology/*immunology
MH  - Humans
MH  - Lung/*cytology/*immunology/pathology
MH  - Macrophages/*cytology/*immunology
MH  - *Rest
PMC - PMC6392073
MID - NIHMS1007960
EDAT- 2019/02/27 06:00
MHDA- 2019/09/20 06:00
PMCR- 2019/02/27
CRDT- 2019/02/27 06:00
PHST- 2019/02/27 06:00 [entrez]
PHST- 2019/02/27 06:00 [pubmed]
PHST- 2019/09/20 06:00 [medline]
PHST- 2019/02/27 00:00 [pmc-release]
AID - 33ef53647edb3659,6a21e6d63b5139f8 [pii]
AID - 10.1615/CritRevImmunol.2018026459 [doi]
PST - ppublish
SO  - Crit Rev Immunol. 2018;38(4):303-331. doi: 10.1615/CritRevImmunol.2018026459.