PMID- 30806289
OWN - NLM
STAT- MEDLINE
DCOM- 20190321
LR  - 20190321
IS  - 2162-6537 (Electronic)
IS  - 0731-8898 (Linking)
VI  - 38
IP  - 1
DP  - 2019
TI  - Asthma-Alleviating Potential of 6-Gingerol: Effect on Cytokines, Related mRNA and 
      c-Myc, and NFAT1 Expression in Ovalbumin-Sensitized Asthma in Rats.
PG  - 41-50
LID - 10.1615/JEnvironPatholToxicolOncol.2018027172 [doi]
AB  - In this study, we aimed at assessing the therapeutical potential of 6-gingerol 
      ([5S]-5-hydroxy-1-[4-hydroxy- 3-methoxyphenyl]-3-decanone) against 
      ovalbumin-sensitized asthma in rats. The rats were treated intraperitoneally with 
      6-gingerol (75 mg/kg body weight) for 30 days and a theophylline (200 mg/kg body 
      weight)-treated group as a control. Changes in the levels of T-cell-linked 
      cytokines (interleukin-4 [IL-4], IL-5, IL-13, and interferon-gamma [IFN-?]), 
      total immunoglobulin E (IgE), gene expressions of bitter taste-sensing type 
      2-receptor 10 (T2R10), inositol 1,4,5-triphosphate receptor 1 (IP3R1), Orai1 and 
      protein expressions of nuclear factor of activated T cells 1 (NFAT1), c-Myc and 
      histopathological changes were observed in rats. 6-Gingerol exerts its beneficial 
      impacts like theophylline in lessening IL-4, IL-5, and IL-13, and IgE and 
      increasing the level of IFN-?. Significant down-regulation of T2R10 gene 
      expression and up-regulation of IP3R1 and Orai1 gene expression were observed in 
      experimental rats and these alterations were normalized after treatment with 
      6-gingerol or theophylline. The histopathological study revealed that the 
      accumulation of glycoprotein and thickness of alveolar epithelium in asthmatic 
      rats and supplementation with 6-gingerol or theophylline in asthmatic rats 
      restored these changes to normal. In conclusion, 6-gingerol has a protective 
      effect on lungs in ovalbumin-sensitized asthma in rats.
FAU - Li, Zaoni
AU  - Li Z
AD  - Medical Clinic of Shangluo Central Hospital, Shangluo, Shaanxi Province, 
      China-726000.
FAU - Liu, Zhongxi
AU  - Liu Z
AD  - Department of Respiratory Medicine in Daqing Oilfield General Hospital, Daqing, 
      Heilongjiang Province, China-163000.
FAU - Uddandrao, V V Sathibabu
AU  - Uddandrao VVS
AD  - Department of Biochemistry, Centre for Biological Sciences, K.S. Rangasamy 
      College of Arts and Science (Autonomous), Tiruchengode, Namakkal Dt, 
      Tamilnadu-637215.
FAU - Ponnusamy, Ponmurugan
AU  - Ponnusamy P
AD  - Department of Botany, Bharathiar University, Coimbatore 641 046, Tamil Nadu, 
      India.
FAU - Balakrishnan, Santhanaraj
AU  - Balakrishnan S
AD  - College of Applied Medical Sciences, Majmaah University, Al Majmaah, The Kingdom 
      of Saudi Arabia- 15341; Department of Bio-Medical Engineering, Velalar College of 
      Engineering and Technology, Thindal, Erode-638012, Tamilnadu, India.
FAU - Brahmanaidu, P
AU  - Brahmanaidu P
AD  - ICMR-National Animal Resource Facility for Biomedical Research (NARFBR), 
      Hyderabad, Telangana, India-500007.
FAU - Vadivukkarasi, S
AU  - Vadivukkarasi S
AD  - Department of Biochemistry, Centre for Biological Sciences, K.S. Rangasamy 
      College of Arts and Science (Autonomous), Tiruchengode, Namakkal Dt, 
      Tamilnadu-637215.
FAU - Ganapathy, Saravanan
AU  - Ganapathy S
AD  - Department of Biochemistry, Centre for Biological Sciences, K.S. Rangasamy 
      College of Arts and Science (Autonomous), Tiruchengode, Namakkal Dt, 
      Tamilnadu-637215.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Environ Pathol Toxicol Oncol
JT  - Journal of environmental pathology, toxicology and oncology : official organ of 
      the International Society for Environmental Toxicology and Cancer
JID - 8501420
RN  - 0 (Catechols)
RN  - 0 (Cytokines)
RN  - 0 (Fatty Alcohols)
RN  - 0 (NFATC Transcription Factors)
RN  - 0 (RNA, Messenger)
RN  - 925QK2Z900 (gingerol)
SB  - IM
MH  - Animals
MH  - Asthma/*drug therapy/genetics/metabolism
MH  - Catechols/chemistry/pharmacology/*therapeutic use
MH  - Cytokines/metabolism
MH  - Fatty Alcohols/chemistry/pharmacology/*therapeutic use
MH  - Genes, myc
MH  - Male
MH  - NFATC Transcription Factors/genetics/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2019/02/27 06:00
MHDA- 2019/03/22 06:00
CRDT- 2019/02/27 06:00
PHST- 2019/02/27 06:00 [entrez]
PHST- 2019/02/27 06:00 [pubmed]
PHST- 2019/03/22 06:00 [medline]
AID - 4b309b253eb144f8,795b4f956e886a4a [pii]
AID - 10.1615/JEnvironPatholToxicolOncol.2018027172 [doi]
PST - ppublish
SO  - J Environ Pathol Toxicol Oncol. 2019;38(1):41-50. doi: 
      10.1615/JEnvironPatholToxicolOncol.2018027172.