PMID- 30806310
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20190812
IS  - 1873-4316 (Electronic)
IS  - 1389-2010 (Linking)
VI  - 20
IP  - 2
DP  - 2019
TI  - Comparative Evaluation of Conventional and Novel Extracts of Stem Bark of 
      Terminalia arjuna for Antihypertensive Activity in BSO Induced Oxidative Stress 
      based Rat Model.
PG  - 157-167
LID - 10.2174/1389201020666190222185209 [doi]
AB  - BACKGROUND: Terminalia arjuna (TA) has been reported and explored traditionally 
      for its cardiotonic properties while the mechanism of antihypertensive effect of 
      TA has not been clearly reported. METHOD: The oxidative stress is a major cause 
      for hypertension, hence different extracts of TA having variable marker yield 
      were evaluated for their antihypertensive effect in buthionine sulfoxamine (BSO) 
      induced oxidative stress based model. Soxhlet extraction (SE), room temperature 
      extraction (RTE), microwave assisted extraction (MAE), and ultrasound assisted 
      extraction (USAE) were quantitatively estimated for marker compounds arjunolic 
      acid and arjunic acid through HPTLC. RESULTS: The hypertension was induced using 
      buthionine sulfoxamine (2 mmol/kg b.w. i.p.) and results suggested that the MAE 
      and USAE showed better recovery of systolic blood pressure (110.33+/-0.10 and 
      118.33+/-0.10) and GSH level (3.62+/-0.07 nmoles/mL and 3.22+/-0.13 nmoles/mL), 
      respectively as compared to the positive control group treated with ascorbic acid 
      (Systolic BP: 119.67+/-0.10, GSH level: 3.11+/-0.10 nmoles/mL). The RTE and SE also 
      showed a decrease in hypertension but were having moderate effect as compared 
      with the standard positive control. CONCLUSION: The total percentage yield, the 
      yield of the marker compounds arjunolic and arjunic acid, the IC50 values for 
      antioxidant activity as well as the antihypertensive effect were in order: 
      MAE>USAE>SE>RTE that suggested the role of biomarkers arjunolic acid and arjunic 
      acid in reversing the effect of buthionine sulfoxamine.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Khatkar, Sarita
AU  - Khatkar S
AD  - Vaish Institute of Pharmaceutical Education and Research, Rohtak, India.
FAU - Nanda, Arun
AU  - Nanda A
AD  - Faculty of Pharmaceutical Sciences, M.D. University, Rohtak, Haryana 124001, 
      India.
FAU - Ansari, Shahid H
AU  - Ansari SH
AD  - Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Curr Pharm Biotechnol
JT  - Current pharmaceutical biotechnology
JID - 100960530
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Plant Extracts)
RN  - 0 (Triterpenes)
RN  - 0 (arjunic acid)
RN  - 465-00-9 (arjunolic acid)
RN  - 5072-26-4 (Buthionine Sulfoximine)
MH  - Animals
MH  - Antihypertensive Agents/*pharmacology
MH  - Buthionine Sulfoximine
MH  - Female
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Plant Bark/chemistry
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - *Terminalia/chemistry
MH  - Triterpenes/analysis/pharmacology
OTO - NOTNLM
OT  - Soxhlet extraction
OT  - antihypertensive
OT  - buthionine sulfoxamine
OT  - microwave assisted extraction
OT  - oxidative stress
OT  - room temperature extraction
OT  - ultrasound assisted extraction.
EDAT- 2019/02/27 06:00
MHDA- 2019/08/14 06:00
CRDT- 2019/02/27 06:00
PHST- 2018/11/23 00:00 [received]
PHST- 2019/02/07 00:00 [revised]
PHST- 2019/02/10 00:00 [accepted]
PHST- 2019/02/27 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2019/02/27 06:00 [entrez]
AID - CPB-EPUB-96830 [pii]
AID - 10.2174/1389201020666190222185209 [doi]
PST - ppublish
SO  - Curr Pharm Biotechnol. 2019;20(2):157-167. doi: 
      10.2174/1389201020666190222185209.