PMID- 30807145
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20190415
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 67
IP  - 12
DP  - 2019 Mar 27
TI  - Insights into In Vivo Absolute Oral Bioavailability, Biotransformation, and 
      Toxicokinetics of Zearalenone, alpha-Zearalenol, beta-Zearalenol, 
      Zearalenone-14-glucoside, and Zearalenone-14-sulfate in Pigs.
PG  - 3448-3458
LID - 10.1021/acs.jafc.8b05838 [doi]
AB  - The aim of this study was to determine the toxicokinetic characteristics of ZEN 
      and its modified forms, alpha-zearalenol (alpha-ZEL), beta-zearalenol (beta-ZEL), 
      zearalenone-14-glucoside (ZEN14G), and zearalenone-14-sulfate (ZEN14S), including 
      presystemic and systemic hydrolysis in pigs. Crossover pig trials were performed 
      by means of intravenous and oral administration of ZEN and its modified forms. 
      Systemic plasma concentrations of the administered toxins and their metabolites 
      were quantified and further processed via tailor-made compartmental toxicokinetic 
      models. Furthermore, portal plasma was analyzed to unravel the site of 
      hydrolysis, and urine samples were analyzed to determine urinary excretion. 
      Results demonstrate complete presystemic hydrolysis of ZEN14G and ZEN14S to ZEN 
      and high oral bioavailability for all administered compounds, with further 
      extensive first-pass glucuronidation. Conclusively, the modified-ZEN forms alpha-ZEL, 
      beta-ZEL, ZEN14G, and ZEN14S contribute to overall ZEN systemic toxicity in pigs and 
      should be taken into account for risk assessment.
FAU - Catteuw, Amelie
AU  - Catteuw A
AUID- ORCID: 0000-0001-8463-2184
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine , Ghent University , Salisburylaan 133 , 9820 Merelbeke , Belgium.
FAU - Broekaert, Nathan
AU  - Broekaert N
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine , Ghent University , Salisburylaan 133 , 9820 Merelbeke , Belgium.
FAU - De Baere, Siegrid
AU  - De Baere S
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine , Ghent University , Salisburylaan 133 , 9820 Merelbeke , Belgium.
FAU - Lauwers, Marianne
AU  - Lauwers M
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine , Ghent University , Salisburylaan 133 , 9820 Merelbeke , Belgium.
FAU - Gasthuys, Elke
AU  - Gasthuys E
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine , Ghent University , Salisburylaan 133 , 9820 Merelbeke , Belgium.
FAU - Huybrechts, Bart
AU  - Huybrechts B
AD  - Sciensano , Juliette Wytsmanstraat 14 , 1050 Elsene , Belgium.
FAU - Callebaut, Alfons
AU  - Callebaut A
AD  - Sciensano , Juliette Wytsmanstraat 14 , 1050 Elsene , Belgium.
FAU - Ivanova, Lada
AU  - Ivanova L
AD  - Chemistry Section , Norwegian Veterinary Institute , Ullevalsveien 68 , 0454 Oslo 
      , Norway.
FAU - Uhlig, Silvio
AU  - Uhlig S
AD  - Chemistry Section , Norwegian Veterinary Institute , Ullevalsveien 68 , 0454 Oslo 
      , Norway.
FAU - De Boevre, Marthe
AU  - De Boevre M
AUID- ORCID: 0000-0002-6151-5126
AD  - Department of Bioanalysis, Faculty of Pharmaceutical Sciences , Ghent University 
      , Ottergemsesteenweg 460 , 9000 Ghent , Belgium.
FAU - De Saeger, Sarah
AU  - De Saeger S
AUID- ORCID: 0000-0002-2160-7253
AD  - Department of Bioanalysis, Faculty of Pharmaceutical Sciences , Ghent University 
      , Ottergemsesteenweg 460 , 9000 Ghent , Belgium.
FAU - Gehring, Ronette
AU  - Gehring R
AD  - Institute of Computational Comparative Medicine, College of Veterinary Medicine , 
      Kansas State University , 1700 Denison Ave , Manhattan , Kansas 66506 , United 
      States.
AD  - Institute of Risk Assessment Sciences, Division of Toxicology/Pharmacology , 
      Utrecht University , Yalelaan 1 , 3584 CL Utrecht , The Netherlands.
FAU - Devreese, Mathias
AU  - Devreese M
AUID- ORCID: 0000-0003-2512-4176
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine , Ghent University , Salisburylaan 133 , 9820 Merelbeke , Belgium.
AD  - Institute of Computational Comparative Medicine, College of Veterinary Medicine , 
      Kansas State University , 1700 Denison Ave , Manhattan , Kansas 66506 , United 
      States.
FAU - Croubels, Siska
AU  - Croubels S
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine , Ghent University , Salisburylaan 133 , 9820 Merelbeke , Belgium.
LA  - eng
PT  - Journal Article
DEP - 20190313
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Glucosides)
RN  - 0 (Mycotoxins)
RN  - 0 (Sulfates)
RN  - 0 (zearalenol)
RN  - 5W827M159J (Zearalenone)
RN  - 76LO2L2V39 (Zeranol)
SB  - IM
MH  - Animals
MH  - Biological Availability
MH  - Biotransformation
MH  - Glucosides/chemistry/metabolism
MH  - Kinetics
MH  - Male
MH  - Mycotoxins/chemistry/*metabolism/toxicity
MH  - Sulfates/chemistry/metabolism
MH  - Swine/*metabolism
MH  - Toxicokinetics
MH  - Zearalenone/chemistry/*metabolism/toxicity
MH  - Zeranol/*analogs & derivatives/chemistry/metabolism/toxicity
OTO - NOTNLM
OT  - pig
OT  - toxicokinetics
OT  - zearalenone
OT  - zearalenone-14-glucoside
OT  - zearalenone-14-sulfate
EDAT- 2019/02/27 06:00
MHDA- 2019/04/16 06:00
CRDT- 2019/02/27 06:00
PHST- 2019/02/27 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
PHST- 2019/02/27 06:00 [entrez]
AID - 10.1021/acs.jafc.8b05838 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2019 Mar 27;67(12):3448-3458. doi: 10.1021/acs.jafc.8b05838. 
      Epub 2019 Mar 13.