PMID- 30807638
OWN - NLM
STAT- MEDLINE
DCOM- 20190726
LR  - 20190726
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 60
IP  - 2
DP  - 2019 Feb 1
TI  - Changes in Peripapillary Microvasculature and Retinal Thickness in the Fellow 
      Eyes of Patients With Unilateral Retinal Vein Occlusion: An OCTA Study.
PG  - 823-829
LID - 10.1167/iovs.18-26288 [doi]
AB  - PURPOSE: To evaluate changes in peripapillary microvascular parameters in the 
      fellow eyes of patients with unilateral retinal vein occlusion (RVO) using 
      optical coherence tomography angiography (OCTA) and to determine the 
      relationships between peripapillary microvasculature and retinal nerve fiber 
      layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness. METHODS: 
      Eighty-three patients with unilateral RVO (50 patients with branch RVO and 33 
      with central RVO) and 83 normal controls were enrolled. OCTA (Cirrus HD-OCT 5000 
      with AngioPlex) 6 x 6-mm scans centered on the optic disc were acquired. 
      Peripapillary vessel density (VD) and perfusion density (PD) were automatically 
      calculated. RESULTS: The average RNFL and GC-IPL thicknesses in the fellow eyes 
      of RVO patients were significantly thinner than in normal controls (93.5 vs. 96.6 
      mum, P = 0.013 and 81.3 vs. 84.1 mum, P = 0.003, respectively). In the fellow eyes 
      of patients with unilateral RVO, the peripapillary VD of the inner ring, outer 
      ring, and full area (17.47, 18.50, and 17.89, respectively) were significantly 
      lower than those of controls (17.87, 18.87, and 18.27, respectively). The 
      peripapillary PD of the inner ring, outer ring, and full area (0.456, 0.467, and 
      0.456, respectively) were also significantly lower than those of controls (0.468, 
      0.476, and 0.466, respectively). RNFL and GC-IPL thicknesses were correlated with 
      both peripapillary VD and PD. CONCLUSIONS: OCTA revealed that peripapillary 
      microvascular parameters in the fellow eyes of patients with unilateral RVO were 
      decreased, and GC-IPL and RNFL thinning were also observed. The RNFL and GC-IPL 
      thicknesses were positively correlated with both peripapillary VD and PD.
FAU - Shin, Yong-Il
AU  - Shin YI
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Nam, Ki Yup
AU  - Nam KY
AD  - Department of Ophthalmology, Kosin University College of Medicine, Busan, 
      Republic of Korea.
FAU - Lee, Seong Eun
AU  - Lee SE
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Lim, Hyung-Bin
AU  - Lim HB
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Lee, Min Woo
AU  - Lee MW
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Jo, Young-Joon
AU  - Jo YJ
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Kim, Jung-Yeul
AU  - Kim JY
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
MH  - Aged
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Microvessels/diagnostic imaging/pathology
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Optic Disk/*blood supply/diagnostic imaging
MH  - Organ Size
MH  - Retina/diagnostic imaging/*pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Retinal Vein Occlusion/diagnostic imaging/*pathology
MH  - Retinal Vessels/diagnostic imaging/*pathology
MH  - Tomography, Optical Coherence/*methods
EDAT- 2019/02/27 06:00
MHDA- 2019/07/28 06:00
CRDT- 2019/02/27 06:00
PHST- 2019/02/27 06:00 [entrez]
PHST- 2019/02/27 06:00 [pubmed]
PHST- 2019/07/28 06:00 [medline]
AID - 2726812 [pii]
AID - 10.1167/iovs.18-26288 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):823-829. doi: 10.1167/iovs.18-26288.