PMID- 30808504
OWN - NLM
STAT- MEDLINE
DCOM- 20201013
LR  - 20201013
IS  - 1578-8989 (Electronic)
IS  - 0025-7753 (Linking)
VI  - 153
IP  - 8
DP  - 2019 Oct 25
TI  - Clinical profile and associated factors of pulmonary involvement in primary 
      Sjogren's syndrome.
PG  - 305-311
LID - S0025-7753(19)30062-4 [pii]
LID - 10.1016/j.medcli.2019.01.016 [doi]
AB  - OBJECTIVES: The aim of this study is to identify the clinical characteristics of 
      primary Sjogren's syndrome (PSS) patients with pulmonary involvement and the 
      associated factors for pulmonary involvement in PSS. METHODS: We retrospectively 
      reviewed clinical features, laboratory examinations, imaging tests, pathological 
      results and therapeutic strategy of 367 PSS patients. Comparisons were made 
      between two subgroups: PSS with pulmonary involvement and those without. 
      Correlation between the pathology of minor salivary gland biopsy (MSGB) and 
      diverse features with pulmonary involvement were detected by Pearson correlation 
      analysis and associated factors were selected by multivariate logistic regression 
      analysis. RESULTS: The lung involved PSS patients had significantly higher level 
      of inflammatory associated indexes (p<0.05). There is no significant correlation 
      between pathology of MSGB and lung involvements. Age, elevated neutrophils level 
      and hypoproteinemia are significantly associated with lung disease with in PSS 
      cohort (p<0.05). As for therapeutic strategy, moderate dose prednisone 
      (15-40mg/d) and cyclophosphamide (CTX) are mainly different between two 
      subgroups. CONCLUSIONS: PSS patients with pulmonary involvements show enhanced 
      inflammation. Age, elevated neutrophils level and hypoproteinemia are independent 
      associated with pulmonary involvements in PSS patients. For those PSS with 
      pulmonary involvement moderate dose of prednisone and CTX were still the 
      mainstream.
CI  - Copyright (c) 2019 Elsevier Espana, S.L.U. All rights reserved.
FAU - Jin, Yi
AU  - Jin Y
AD  - Rheumatology Department, The Second Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325035, China.
FAU - Zhang, Ting
AU  - Zhang T
AD  - Department of Pulmonary and Critical Care Medicine, The First People's Hospital 
      of Wenling, Wenling, Zhenjiang 317500, China.
FAU - Ye, Wenjing
AU  - Ye W
AD  - Rheumatology Department, The Third Affiliated Hospital of Wenzhou Medical 
      University, Ruian People's Hospital, Wenzhou, Zhejiang 325200, China.
FAU - Zhu, Xiaochun
AU  - Zhu X
AD  - Rheumatology Department, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325035, China.
FAU - Wang, Liangxing
AU  - Wang L
AD  - Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325035, China.
FAU - Wang, Xiaobing
AU  - Wang X
AD  - Rheumatology Department, The First Affiliated Hospital of Wenzhou Medical 
      University, Nanbaixiang Street, Ouhai District, Wenzhou, Zhejiang 325035, China. 
      Electronic address: gale820907@163.com.
LA  - eng
LA  - spa
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190223
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Lung Diseases/diagnosis/*etiology/therapy
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sjogren's Syndrome/complications/*diagnosis/therapy
OTO - NOTNLM
OT  - Enfermedad pulmonar
OT  - Hipoproteinemia
OT  - Hypoproteinemia
OT  - Lung disease
OT  - Primary Sjogren's syndrome
OT  - Sindrome de Sjogren primario
EDAT- 2019/02/28 06:00
MHDA- 2020/10/21 06:00
CRDT- 2019/02/28 06:00
PHST- 2018/07/31 00:00 [received]
PHST- 2019/01/15 00:00 [revised]
PHST- 2019/01/17 00:00 [accepted]
PHST- 2019/02/28 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/02/28 06:00 [entrez]
AID - S0025-7753(19)30062-4 [pii]
AID - 10.1016/j.medcli.2019.01.016 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2019 Oct 25;153(8):305-311. doi: 10.1016/j.medcli.2019.01.016. 
      Epub 2019 Feb 23.