PMID- 30808582
OWN - NLM
STAT- MEDLINE
DCOM- 20200703
LR  - 20200703
IS  - 1778-3585 (Electronic)
IS  - 0924-9338 (Linking)
VI  - 60
DP  - 2019 Aug
TI  - High BDNF serum levels are associated to good cognitive functioning in bipolar 
      disorder.
PG  - 97-107
LID - S0924-9338(19)30044-6 [pii]
LID - 10.1016/j.eurpsy.2019.02.006 [doi]
AB  - BACKGROUND: Neurotrophins such as brain-derived neurotrophic factor (BDNF), 
      inflammation and oxidative damage may contribute to the pathophysiology of 
      bipolar disorder (BD) in terms of illness activity. To date, there is a lack of 
      studies linking the cognitive impairment observed in BD with these 
      neurobiological mechanisms. This study aimed to investigate the role of these 
      neurobiological factors in clinical and cognitive outcomes in a sample of bipolar 
      individuals. METHODS: We measured serum BDNF, cytokines and oxidative stress 
      markers in a sample of 133 individuals: 52 euthymic bipolar patients, 32 manic 
      patients and 49 healthy controls. They were all assessed with a comprehensive 
      cognitive battery. Sociodemographic and clinical data were collected. Multiple 
      linear regression models were built to study associations of neurotrophins and 
      inflammatory and oxidative measures with cognitive functioning. RESULTS: BDNF 
      levels were decreased in euthymic (p = 0.039) and manic (p < 0.001) individuals. 
      Conversely, inflammatory (interleukin 6 (IL-6)) (p = 0.019) and oxidative stress 
      (p = 0.003) measures were increased in bipolar individuals compared to controls. 
      BDNF levels were associated with executive functioning (beta = 0.01, p = 0.02) and 
      verbal memory (beta = 0.013, p = 0.005), together with other demographic variables. 
      In particular, verbal memory was also associated with obesity (beta=-0.04, 
      p = 0.005). Neither inflammatory markers, oxidative stress markers nor other 
      relevant clinical variables showed any association with cognitive outcome. 
      CONCLUSIONS: Of all the peripheral neurobiological factors analysed, BDNF was the 
      only one significantly associated with cognitive dysfunction in bipolar disorder 
      individuals. This study emphasizes the role of BDNF not only across mood phases 
      but also in cognitive functioning.
CI  - Copyright (c) 2019 Elsevier Masson SAS. All rights reserved.
FAU - Mora, Ester
AU  - Mora E
AD  - Psychiatric Service, Hospital Universitari Santa Maria, Biological Foundation of 
      Mental Disorders, Lleida Institute for Biomedical Research Dr. Pifarre 
      Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain; Child and 
      Adolescent Mental Health Centre, Hospital Sant Joan de Deu Terres de Lleida, 
      Catalonia, Spain. Electronic address: ester.mora@sjd-lleida.org.
FAU - Portella, Maria J
AU  - Portella MJ
AD  - Psychiatric Service, Research Institute, Hospital de Santa Creu i Sant Pau, 
      Autonomous University of Barcelona, CIBERSAM, Barcelona, Catalonia, Spain. 
      Electronic address: mportella@santpau.cat.
FAU - Pinol-Ripoll, Gerard
AU  - Pinol-Ripoll G
AD  - Cognitive Disorders Unit, Hospital Universitari Santa Maria, Neuroscience 
      Clinical Group, Lleida Institute for Biomedical Research Dr. Pifarre Foundation, 
      IRBLleida, University of Lleida, Lleida, Catalonia, Spain.
FAU - Lopez, Ricard
AU  - Lopez R
AD  - Laboratory Department, Hospital Universitari Arnau de Vilanova, Lleida Institute 
      for Biomedical Research Dr. Pifarre Foundation, IRBLleida, University of Lleida, 
      Lleida, Catalonia, Spain.
FAU - Cuadras, Daniel
AU  - Cuadras D
AD  - Statistics Unit. Sant Joan de Deu Research Fundation, Parc Sanitari Sant Joan de 
      Deu, Sant Boi de Llobregat, Barcelona, Catalonia, Spain.
FAU - Forcada, Irene
AU  - Forcada I
AD  - Psychiatric Service, Hospital Universitari Santa Maria, Biological Foundation of 
      Mental Disorders, Lleida Institute for Biomedical Research Dr. Pifarre 
      Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain.
FAU - Teres, Montse
AU  - Teres M
AD  - Psychiatric Service, Hospital Universitari Santa Maria, Biological Foundation of 
      Mental Disorders, Lleida Institute for Biomedical Research Dr. Pifarre 
      Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain.
FAU - Vieta, Eduard
AU  - Vieta E
AD  - Bipolar Disorder Program, Hospital Clinic, Institute of Neuroscience, University 
      of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
FAU - Mur, Maria
AU  - Mur M
AD  - Psychiatric Service, Hospital Universitari Santa Maria, Biological Foundation of 
      Mental Disorders, Lleida Institute for Biomedical Research Dr. Pifarre 
      Foundation, IRBLleida, University of Lleida, Lleida, Catalonia, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190223
PL  - England
TA  - Eur Psychiatry
JT  - European psychiatry : the journal of the Association of European Psychiatrists
JID - 9111820
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - *Bipolar Disorder/diagnosis/metabolism/psychology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition/*physiology
MH  - Correlation of Data
MH  - Executive Function/*physiology
MH  - Female
MH  - Humans
MH  - Inflammation/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Neurobiology/methods
MH  - Neuropsychological Tests
MH  - Oxidative Stress/physiology
OTO - NOTNLM
OT  - BNDF
OT  - Bipolar disorder
OT  - Cognition
OT  - Neurobiological factor
EDAT- 2019/02/28 06:00
MHDA- 2020/07/04 06:00
CRDT- 2019/02/28 06:00
PHST- 2018/12/28 00:00 [received]
PHST- 2019/02/18 00:00 [revised]
PHST- 2019/02/18 00:00 [accepted]
PHST- 2019/02/28 06:00 [pubmed]
PHST- 2020/07/04 06:00 [medline]
PHST- 2019/02/28 06:00 [entrez]
AID - S0924-9338(19)30044-6 [pii]
AID - 10.1016/j.eurpsy.2019.02.006 [doi]
PST - ppublish
SO  - Eur Psychiatry. 2019 Aug;60:97-107. doi: 10.1016/j.eurpsy.2019.02.006. Epub 2019 
      Feb 23.