PMID- 30808615
OWN - NLM
STAT- MEDLINE
DCOM- 20210928
LR  - 20210928
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Print)
IS  - 0007-1161 (Linking)
VI  - 105
IP  - 9
DP  - 2021 Sep
TI  - Right-angled vessels in macular telangiectasia type 2.
PG  - 1289-1296
LID - 10.1136/bjophthalmol-2018-313364 [doi]
AB  - PURPOSE: To evaluate the role of right-angled vessels (RAVs) during disease 
      progression in macular telangiectasia type 2 (MacTel). METHODS: In this study, 
      100 eyes of 52 patients and 52 eyes of 26 age-related controls were examined 
      using fundus photography, spectral-domain optical coherence tomography (SD-OCT), 
      OCT angiography (OCT-A) and fundus fluorescein angiography (FFA). Two masked 
      readers graded fundus photographs of patients' eyes into five disease stages 
      according to Gass and Blodi, and evaluated all eyes for the presence of RAVs. If 
      RAVs were present, their course and origin (arterial vs venous) was evaluated 
      with OCT-A and FFA, respectively. Additionally, we looked for morphological 
      correlates of these vessels on SD-OCT scans. Neovascular eyes were analysed for 
      the presence of RAVs and for morphological changes on formation of 
      neovascularisations (NVs). RESULTS: In OCT-A, RAVs were already detectable in 
      eyes with early stages (1 to 2), could be tracked from superficial to outer 
      retinal layers and were shown to form anastomoses in the outer retina with 
      disease progression. These vessels were of both arterial and venous origin as 
      shown by early phase FFA. Dilated capillaries and RAVs in OCT-A corresponded to 
      hyper-reflective alterations of the outer retina on SD-OCT scans. In 19/19 eyes, 
      NVs were associated with the presence of RAVs, and RAVs were shown to directly 
      connect to neovascular complexes and to undergo morphological changes upon NV 
      formation. CONCLUSIONS: The results emphasise the role of RAVs during disease 
      progression from an early stage on and demonstrate their involvement in the 
      development of secondary NVs in MacTel.
CI  - (c) Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Tzaridis, Simone
AU  - Tzaridis S
AD  - Department of Ophthalmology, University Hospital Bonn, Bonn, Germany 
      Simone.Mueller@ukb.uni-bonn.de.
FAU - Heeren, Tjebo
AU  - Heeren T
AUID- ORCID: 0000-0001-5297-2301
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
AD  - Institute of Ophthalmology, University College London, London, UK.
FAU - Mai, Clarissa
AU  - Mai C
AD  - Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.
FAU - Thiele, Sarah
AU  - Thiele S
AD  - Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.
FAU - Holz, Frank G
AU  - Holz FG
AD  - Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.
FAU - Charbel Issa, Peter
AU  - Charbel Issa P
AUID- ORCID: 0000-0002-0351-6673
AD  - Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, and 
      Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical 
      Neurosciences, University of Oxford, Oxford, UK.
FAU - Herrmann, Philipp
AU  - Herrmann P
AD  - Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20190226
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
RN  - Idiopathic Juxtafoveal Retinal Telangiectasia
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - Macula Lutea/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Retinal Telangiectasis/*diagnosis/physiopathology
MH  - Retinal Vessels/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
PMC - PMC8380913
OTO - NOTNLM
OT  - imaging
OT  - macula
OT  - neovascularisation
OT  - retina
COIS- Competing interests: None declared.
EDAT- 2019/02/28 06:00
MHDA- 2021/09/29 06:00
PMCR- 2021/08/23
CRDT- 2019/02/28 06:00
PHST- 2018/10/10 00:00 [received]
PHST- 2018/12/14 00:00 [revised]
PHST- 2019/02/05 00:00 [accepted]
PHST- 2019/02/28 06:00 [pubmed]
PHST- 2021/09/29 06:00 [medline]
PHST- 2019/02/28 06:00 [entrez]
PHST- 2021/08/23 00:00 [pmc-release]
AID - bjophthalmol-2018-313364 [pii]
AID - 10.1136/bjophthalmol-2018-313364 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2021 Sep;105(9):1289-1296. doi: 
      10.1136/bjophthalmol-2018-313364. Epub 2019 Feb 26.