PMID- 30808836
OWN - NLM
STAT- MEDLINE
DCOM- 20190422
LR  - 20190422
IS  - 1423-0143 (Electronic)
IS  - 1420-4096 (Linking)
VI  - 44
IP  - 1
DP  - 2019
TI  - Association Between the Lipid Profile and Renal Dysfunction in the Heart Failure 
      Patients.
PG  - 52-61
LID - 10.1159/000498834 [doi]
AB  - BACKGROUND/AIMS: In heart failure patients with high prevalence of chronic renal 
      disease (CKD), hospitalization and mortality, whether the lipid profile was 
      associated with renal dysfunction remained unknown. The present study intended to 
      clarify the association between the lipid profile and renal dysfunction in the 
      heart failure patients. METHODS: 336 hospitalized heart failure patients with 
      left ventricle ejection fraction (LVEF) </=45% and New York Heart Association 
      (NYHA) class II-IV were enrolled. The estimated glomerular filtration rate (eGFR) 
      < 90 mL/min.1.73 m2 was defined as renal dysfunction. The demographic, clinical 
      data, blood samples and echocardiography were documented. The Pearson simple 
      linear correlation was performed to evaluate the confounding factors correlated 
      with eGFR. The significantly correlated factors were enrolled in Logistic 
      regression as confounding factors to determine the association between the lipid 
      profile and renal dysfunction in the heart failure patients. RESULTS: 182 
      patients (54.2%) had renal dysfunction and 154 patients (45.8%) did not have 
      renal dysfunction. The waist circumference, platelet counts, platelet 
      distribution width (PDW), high density lipoprotein-cholesterol (HDL-C), 
      apolipoprotein A1 (apoA1), albumin and left ventricular ejection fraction (LVEF) 
      are positively correlated with eGFR (all P< 0.05). Meanwhile, the age, mean 
      platelet volume (MPV), neutrophilic granulocyte percentage (NEUT%), urea nitrogen 
      (BUN), creatinine and total bilirubin (TBIL) are negatively correlated with eGFR 
      (all P< 0.05). The total cholesterol (TC), triglyceride, low density 
      lipoprotein-cholesterol (LDL-C) and apolipoprotein B (apoB) show no correlation 
      with eGFR. After the adjustment of sex, hypertension, diabetes mellitus, age, 
      waist circumference, platelet counts, MPV, PDW, NEUT%, TBIL, albumin and LVEF, 
      HDL-C is the only lipid factor still significantly associated with renal 
      dysfunction in hospitalized heart failure patients (OR=0.119, P=0.003). 
      CONCLUSION: Among the lipid profile of TC, triglyceride, LDL-C, HDL-C, apo A1 and 
      apo B, the HDL-C is the only lipid factor significantly associated with renal 
      dysfunction in hospitalized heart failure patients.
CI  - (c) 2019 The Author(s). Published by S. Karger AG, Basel.
FAU - Zhang, Hong
AU  - Zhang H
AD  - Department of Neurology, People's Hospital of Shaanxi Province, Xi'an, China.
FAU - Shi, Shuang
AU  - Shi S
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      China.
FAU - Zhao, Xiu-Juan
AU  - Zhao XJ
AD  - Department of Ultrasonic Center, Northwest Women and Children's Hospital, Xi'an, 
      China.
FAU - Wang, Jun-Kui
AU  - Wang JK
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      China.
FAU - Liu, Zhong-Wei
AU  - Liu ZW
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      China.
FAU - Liu, Fu-Qiang
AU  - Liu FQ
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      China.
FAU - Zhu, Ling
AU  - Zhu L
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      China.
FAU - Zhu, Shun-Ming
AU  - Zhu SM
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      China.
FAU - Zhang, Yong
AU  - Zhang Y
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      China.
FAU - Pan, Shuo
AU  - Pan S
AD  - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 
      China, parker1985@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20190222
PL  - Switzerland
TA  - Kidney Blood Press Res
JT  - Kidney & blood pressure research
JID - 9610505
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Lipids)
SB  - IM
MH  - Aged
MH  - Cholesterol, HDL/blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Heart Failure/*complications
MH  - Hospitalization
MH  - Humans
MH  - Kidney Diseases/*blood
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - EGFR
OT  - HDL-C
OT  - Heart failure
OT  - Lipid
OT  - Renal dysfunction
EDAT- 2019/02/28 06:00
MHDA- 2019/04/23 06:00
CRDT- 2019/02/28 06:00
PHST- 2019/02/05 00:00 [accepted]
PHST- 2019/02/28 06:00 [pubmed]
PHST- 2019/04/23 06:00 [medline]
PHST- 2019/02/28 06:00 [entrez]
AID - 000498834 [pii]
AID - 10.1159/000498834 [doi]
PST - ppublish
SO  - Kidney Blood Press Res. 2019;44(1):52-61. doi: 10.1159/000498834. Epub 2019 Feb 
      22.