PMID- 30809019
OWN - NLM
STAT- MEDLINE
DCOM- 20201027
LR  - 20220416
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 33
IP  - 7
DP  - 2019 Jul
TI  - Diagnostic algorithm utilising multimodal imaging including optical coherence 
      tomography angiography for the detection of myopic choroidal neovascularisation.
PG  - 1111-1118
LID - 10.1038/s41433-019-0378-2 [doi]
AB  - PURPOSE: To develop a diagnostic algorithm in patients with pathologic myopia who 
      present with typical symptoms or signs of myopic choroidal neovascularisation 
      (mCNV). METHODS: Retrospective study. Patients with high myopia and suspected 
      mCNV underwent fluorescein angiography (FFA), structural spectral-domain optical 
      coherence tomography (SD-OCT) and optical coherence tomography angiography 
      (OCTA). Active mCNV on one imaging modality plus clinical features were 
      considered as the benchmark reference for the other two tests. Sensitivity was 
      calculated for each modality individually and in combination. Morphological 
      features were noted on SD-OCT and OCTA. RESULTS: Twenty-seven eyes of 26 patients 
      were analysed. Sensitivity of SD-OCT or FFA alone was 85.19% (23/27 eyes). 
      Sensitivity of OCTA was 74.07% (20/27 eyes). The sensitivity for SD-OCT combined 
      with OCTA was 96.16% and combined with FFA was 97.80%. On OCTA, a "tight net" 
      appearance was seen in 16 eyes (80%); a core vessel was visible in seven eyes 
      (35%), all with active lesions. A "perilesional halo" was visible in 11 eyes 
      (55%) of which 10 had active lesions. CONCLUSION: When combined, OCTA and SD-OCT 
      or SD-OCT and FFA showed similar higher sensitivities than each modality alone. A 
      tight vascular net and the combination of a perilesional halo and a visible core 
      on OCTA may serve as biomarkers of mCNV activity.
FAU - Bagchi, Akanksha
AU  - Bagchi A
AD  - NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, UK. 
      akanksha.bagchi@gmail.com.
FAU - Schwartz, Roy
AU  - Schwartz R
AUID- ORCID: 0000-0003-3487-5713
AD  - NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, UK.
FAU - Hykin, Philip
AU  - Hykin P
AD  - NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, UK.
FAU - Sivaprasad, Sobha
AU  - Sivaprasad S
AUID- ORCID: 0000-0001-8952-0659
AD  - NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, UK.
LA  - eng
PT  - Journal Article
DEP - 20190226
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
CIN - Eye (Lond). 2021 Jan;35(1):349-350. PMID: 32029917
MH  - *Algorithms
MH  - Choroidal Neovascularization/diagnosis/etiology
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multimodal Imaging/*methods
MH  - Myopia, Degenerative/*complications/diagnosis
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
PMC - PMC6707326
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/02/28 06:00
MHDA- 2020/10/28 06:00
PMCR- 2020/07/01
CRDT- 2019/02/28 06:00
PHST- 2018/10/14 00:00 [received]
PHST- 2019/02/10 00:00 [accepted]
PHST- 2019/02/04 00:00 [revised]
PHST- 2019/02/28 06:00 [pubmed]
PHST- 2020/10/28 06:00 [medline]
PHST- 2019/02/28 06:00 [entrez]
PHST- 2020/07/01 00:00 [pmc-release]
AID - 10.1038/s41433-019-0378-2 [pii]
AID - 378 [pii]
AID - 10.1038/s41433-019-0378-2 [doi]
PST - ppublish
SO  - Eye (Lond). 2019 Jul;33(7):1111-1118. doi: 10.1038/s41433-019-0378-2. Epub 2019 
      Feb 26.