PMID- 30809224
OWN - NLM
STAT- MEDLINE
DCOM- 20200116
LR  - 20200309
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 10
DP  - 2019
TI  - Identification of Soluble Mediators in IgG-Mediated Anaphylaxis via Fcgamma Receptor: 
      A Meta-Analysis.
PG  - 190
LID - 10.3389/fimmu.2019.00190 [doi]
LID - 190
AB  - Background: Anaphylaxis is an acute and life-threatening allergic response. 
      Classically and most commonly, it can be mediated by the crosslinking of 
      allergens to immunoglobulin E (IgE)- high affinity IgE receptor (FcepsilonRI) complex 
      found mostly on mast cells. However, there is another pathway of anaphylaxis that 
      is less well-studied. This pathway known as the alternative pathway is mediated 
      by IgG and its Fc gamma receptor (Fcgamma). Though it was not documented in human 
      anaphylaxis, a few studies have found that IgG-mediated anaphylaxis can happen as 
      demonstrated in rodent models of anaphylaxis. In these studies, a variety of 
      soluble mediators were being evaluated and they differ from each study which 
      causes confusion in the suitability, and reliability of choice of soluble 
      mediators to be analyzed for diagnosis or therapeutic purposes. Hence, the 
      objective of this meta-analysis is to identify the potential soluble mediators 
      that are involved in an IgG-mediated anaphylaxis reaction. Methods: Studies 
      related to IgG-mediated anaphylaxis were sourced from five search engines namely 
      PubMed, Scopus, Ovid, Cochrane Library, and Center for Agricultural Bioscience 
      International (CABI) regardless of publication year. Relevant studies were then 
      reviewed based on specific inclusion factors. The means and standard deviations 
      of each soluble mediator studied were then extracted using ImageJ or Get Data 
      Graph Digitiser software and the data were subjected to meta-analysis. Results: 
      From our findings, we found that histamine, serotonin, platelet activating factor 
      (PAF), beta-hexosaminidase, leukotriene C4 (LTC(4)), mucosal mast cell protease-1 
      (MMCP-1), interleukins (IL)-4,-6, and-13; tumor necrosis factor alpha (TNF-alpha), 
      and macrophage inflammatory protein-1alpha (MIP-1alpha) were often being analyzed. Out of 
      these soluble mediators, histamine, PAF, beta-hexosaminidase, IL-6, and-13, MIP-1alpha 
      and TNF-alpha were more significant with positive effect size and p < 0.001. As study 
      effect was relatively small, we performed publication bias and found that there 
      was publication bias and this could be due to the small sample size studied. 
      Conclusion: As such, we proposed that through meta-analysis, the potential 
      soluble mediators involved in rodent IgG-mediated anaphylaxis to be histamine, 
      PAF, beta-hexosaminidase, IL-6 and-13 and MIP-1alpha, and TNF-alpha but will require further 
      studies with larger sample size.
FAU - Kow, Audrey Siew Foong
AU  - Kow ASF
AD  - Department of Biomedical Science, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Serdang, Malaysia.
FAU - Chik, Azirah
AU  - Chik A
AD  - Department of Biomedical Science, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Serdang, Malaysia.
FAU - Soo, Kuan-Meng
AU  - Soo KM
AD  - Department of Microbiology and Parasitology, Faculty of Medicine and Health 
      Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
FAU - Khoo, Leng Wei
AU  - Khoo LW
AD  - Department of Food Science, Faculty of Food Science and Technology, Universiti 
      Putra Malaysia, Serdang, Malaysia.
FAU - Abas, Faridah
AU  - Abas F
AD  - Department of Food Science, Faculty of Food Science and Technology, Universiti 
      Putra Malaysia, Serdang, Malaysia.
AD  - Laboratory of Natural Products, Institute of Bioscience, Universiti Putra 
      Malaysia, Serdang, Malaysia.
FAU - Tham, Chau Ling
AU  - Tham CL
AD  - Department of Biomedical Science, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Serdang, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20190212
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Receptors, IgE)
RN  - 0 (Receptors, IgG)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Anaphylaxis/*etiology/*metabolism
MH  - *Biomarkers/blood
MH  - Cytokines/metabolism
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Immunoglobulin G/*immunology
MH  - Inflammation Mediators/metabolism
MH  - Mast Cells/immunology/metabolism
MH  - Receptors, IgE/metabolism
MH  - Receptors, IgG/*metabolism
MH  - Signal Transduction
PMC - PMC6379333
OTO - NOTNLM
OT  - IgG
OT  - anaphylaxis
OT  - histamine
OT  - interleukins
OT  - meta-analysis
OT  - platelet activating factor
OT  - soluble mediators
EDAT- 2019/02/28 06:00
MHDA- 2020/01/17 06:00
PMCR- 2019/01/01
CRDT- 2019/02/28 06:00
PHST- 2018/09/05 00:00 [received]
PHST- 2019/01/22 00:00 [accepted]
PHST- 2019/02/28 06:00 [entrez]
PHST- 2019/02/28 06:00 [pubmed]
PHST- 2020/01/17 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2019.00190 [doi]
PST - epublish
SO  - Front Immunol. 2019 Feb 12;10:190. doi: 10.3389/fimmu.2019.00190. eCollection 
      2019.