PMID- 30809257
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1687-6121 (Print)
IS  - 1687-630X (Electronic)
IS  - 1687-6121 (Linking)
VI  - 2019
DP  - 2019
TI  - Preoperative Serum Platelet-Lymphocyte Ratio as a Prognostic Factor in 
      Cholangiocarcinoma Patients after Radical Resection: A Retrospective Analysis of 
      119 Patients.
PG  - 8506967
LID - 10.1155/2019/8506967 [doi]
LID - 8506967
AB  - AIMS: Although prognostic markers are important to establish therapeutic 
      strategies in patients for conducting radical resection of cholangiocarcinoma 
      (CCA), there is still a lack of simple, valid, and repeatable markers in clinical 
      settings. We aim to evaluate the prognostic value of the preoperative serum 
      platelet-lymphocyte ratio (PLR) in CCA patients who underwent radical resection. 
      METHODS: We retrospectively analyzed CCA patients who underwent radical resection 
      surgery in our institution from January 2011 to June 2016. Baseline PLR and other 
      clinical pathological data were measured when patients were diagnosed initially. 
      The prognostic value of PLR in overall survival (OS) and progression-free 
      survival (PFS) were analyzed with the Cox proportional hazard model and the 
      Kaplan-Meier method. RESULTS: This study retrospectively analyzed 119 patients 
      who underwent radical resection of CCA. During a median follow-up time of 11.0 
      months, there were 99.2% recurrences and 42.9% who died, and the median OS and 
      PFS were 9.4 months and 7.4 months, respectively. Multivariate Cox analysis 
      identified that elevated levels of PLR (PLR > 157.25) as a significant factor 
      predicted poorer OS (P = 0.018, HR: 2.160, 95% CI: 1.139-4.096) and PFS (P = 
      0.005, HR: 1.930, 95% CI: 1.220-3.053). In subgroup analysis, PLR also 
      effectively predicted OS (P = 0.016, HR: 2.515, 95% CI: 1.143-5.532) and PFS (P = 
      0.042, HR: 1.908, 95% CI: 0.982-3.713) in CCA patients with positive lymphatic 
      metastasis and/or positive surgical margin who required adjuvant therapy. 
      CONCLUSIONS: The preoperative serum PLR is an independent prognostic factor for 
      OS and PFS in CCA patients after radical resection, including patients requiring 
      adjuvant therapy.
FAU - Wu, Ying
AU  - Wu Y
AD  - Department of Oncology, The Second Affiliated Hospital of Nanchang University, 1 
      Minde Road, Nanchang, Jiangxi 330006, China.
AD  - Jiangxi Key Laboratory of Clinical and Translational Cancer Research, Nanchang, 
      Jiangxi 330006, China.
FAU - Zhou, Danyang
AU  - Zhou D
AUID- ORCID: 0000-0002-1932-8554
AD  - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan 430022, China.
FAU - Zhang, Guoping
AU  - Zhang G
AD  - Department of Oncology, Yuebei People's Hospital, Shaoguan, Guangdong 512000, 
      China.
FAU - Yi, Fengming
AU  - Yi F
AUID- ORCID: 0000-0002-9417-644X
AD  - Department of Oncology, The Second Affiliated Hospital of Nanchang University, 1 
      Minde Road, Nanchang, Jiangxi 330006, China.
AD  - Jiangxi Key Laboratory of Clinical and Translational Cancer Research, Nanchang, 
      Jiangxi 330006, China.
FAU - Feng, Long
AU  - Feng L
AUID- ORCID: 0000-0001-8289-1342
AD  - Department of Oncology, The Second Affiliated Hospital of Nanchang University, 1 
      Minde Road, Nanchang, Jiangxi 330006, China.
AD  - Jiangxi Key Laboratory of Clinical and Translational Cancer Research, Nanchang, 
      Jiangxi 330006, China.
LA  - eng
PT  - Journal Article
DEP - 20190128
PL  - Egypt
TA  - Gastroenterol Res Pract
JT  - Gastroenterology research and practice
JID - 101475557
PMC - PMC6369483
EDAT- 2019/02/28 06:00
MHDA- 2019/02/28 06:01
PMCR- 2019/01/28
CRDT- 2019/02/28 06:00
PHST- 2018/09/25 00:00 [received]
PHST- 2018/11/22 00:00 [revised]
PHST- 2018/12/16 00:00 [accepted]
PHST- 2019/02/28 06:00 [entrez]
PHST- 2019/02/28 06:00 [pubmed]
PHST- 2019/02/28 06:01 [medline]
PHST- 2019/01/28 00:00 [pmc-release]
AID - 10.1155/2019/8506967 [doi]
PST - epublish
SO  - Gastroenterol Res Pract. 2019 Jan 28;2019:8506967. doi: 10.1155/2019/8506967. 
      eCollection 2019.