PMID- 30811870
OWN - NLM
STAT- MEDLINE
DCOM- 20200515
LR  - 20200515
IS  - 1521-6551 (Electronic)
IS  - 1521-6543 (Linking)
VI  - 71
IP  - 9
DP  - 2019 Sep
TI  - Long noncoding RNA SOX2-OT facilitates laryngeal squamous cell carcinoma 
      development by epigenetically inhibiting PTEN via methyltransferase EZH2.
PG  - 1230-1239
LID - 10.1002/iub.2026 [doi]
AB  - Long noncoding RNAs (lncRNAs) play important roles in the initiation and 
      progression of various cancers, including laryngeal squamous cell carcinoma 
      (LSCC). Recently, lncRNA Sox2 overlapping transcript (SOX2-OT) has been 
      identified as an oncogene in various cancers. However, the functional role and 
      the regulatory mechanism of SOX2-OT in LSCC remains unclear. In this study, we 
      found that SOX2-OT expression was increased and negatively correlated with PTEN 
      expression in LSCC tissues. Furthermore, SOX2-OT overexpression promoted LSCC 
      cell proliferation, migration, invasion, and suppressed cell apoptosis in vitro, 
      as well as facilitated the in vivo tumorigenicity. By contrast, SOX2-OT silencing 
      exerted the opposite effect. Mechanically, SOX2-OT interacted with EZH2 and 
      recruited EZH2 to induce H3K27me3 and epigenetically inhibited PTEN expression in 
      LSCC cells. Additionally, EZH2 silencing and PTEN overexpression significantly 
      abrogated the SOX2-OT overexpression-mediated promotion of LSCC cell malignant 
      behavior. Collectively, our findings demonstrate that SOX2-OT inhibits PTEN 
      expression to facilitate LSCC development through EZH2-mediated H3K27me3. (c) 2019 
      IUBMB Life, 71(9):1230-1239, 2019.
CI  - (c) 2019 International Union of Biochemistry and Molecular Biology.
FAU - Tai, Yong
AU  - Tai Y
AD  - Department of Otorhinolaryngology, Henan Provincial People's Hospital, Henan 
      University, Zhengzhou, 450003, China.
FAU - Ji, Yuzi
AU  - Ji Y
AD  - Department of Otorhinolaryngology, Henan Provincial People's Hospital, Henan 
      University, Zhengzhou, 450003, China.
FAU - Liu, Fei
AU  - Liu F
AD  - Department of Otorhinolaryngology, Henan Provincial People's Hospital, Henan 
      University, Zhengzhou, 450003, China.
FAU - Zang, Yanzi
AU  - Zang Y
AD  - Department of Otorhinolaryngology, Henan Provincial People's Hospital, Henan 
      University, Zhengzhou, 450003, China.
FAU - Xu, Dingyuan
AU  - Xu D
AD  - Department of Otorhinolaryngology, Henan Provincial People's Hospital, Henan 
      University, Zhengzhou, 450003, China.
FAU - Ma, Song
AU  - Ma S
AD  - Department of Otorhinolaryngology, Henan Provincial People's Hospital, Henan 
      University, Zhengzhou, 450003, China.
FAU - Qin, Litao
AU  - Qin L
AD  - Department of Otorhinolaryngology, Henan Provincial People's Hospital, Henan 
      University, Zhengzhou, 450003, China.
FAU - Ma, Jiqing
AU  - Ma J
AUID- ORCID: 0000-0003-2967-1740
AD  - Department of Otorhinolaryngology, Henan Provincial People's Hospital, Henan 
      University, Zhengzhou, 450003, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190227
PL  - England
TA  - IUBMB Life
JT  - IUBMB life
JID - 100888706
RN  - 0 (RNA, Long Noncoding)
RN  - EC 1.14.11.- (Jumonji Domain-Containing Histone Demethylases)
RN  - EC 2.1.1.43 (EZH2 protein, human)
RN  - EC 2.1.1.43 (Enhancer of Zeste Homolog 2 Protein)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - Animals
MH  - Apoptosis/genetics
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/genetics
MH  - Enhancer of Zeste Homolog 2 Protein/*genetics
MH  - Epigenesis, Genetic/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - Humans
MH  - Jumonji Domain-Containing Histone Demethylases/genetics
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Male
MH  - Mice
MH  - PTEN Phosphohydrolase/*genetics
MH  - RNA, Long Noncoding/genetics
MH  - Transplantation, Heterologous
OTO - NOTNLM
OT  - EZH2
OT  - H3K27me3
OT  - PTEN
OT  - SOX2-OT
OT  - laryngeal squamous cell carcinoma
EDAT- 2019/02/28 06:00
MHDA- 2020/05/16 06:00
CRDT- 2019/02/28 06:00
PHST- 2019/01/22 00:00 [received]
PHST- 2019/02/05 00:00 [accepted]
PHST- 2019/02/28 06:00 [pubmed]
PHST- 2020/05/16 06:00 [medline]
PHST- 2019/02/28 06:00 [entrez]
AID - 10.1002/iub.2026 [doi]
PST - ppublish
SO  - IUBMB Life. 2019 Sep;71(9):1230-1239. doi: 10.1002/iub.2026. Epub 2019 Feb 27.