PMID- 30811895
OWN - NLM
STAT- MEDLINE
DCOM- 20190625
LR  - 20221207
IS  - 2324-9269 (Electronic)
IS  - 2324-9269 (Linking)
VI  - 7
IP  - 5
DP  - 2019 May
TI  - Effects of MTNR1B genetic variants on the risk of type 2 diabetes mellitus: A 
      meta-analysis.
PG  - e611
LID - 10.1002/mgg3.611 [doi]
LID - e611
AB  - BACKGROUND: Whether melatonin receptor 1B (MTNR1B) variants are associated with 
      type 2 diabetes mellitus (T2DM) remains unclear. Therefore, we performed this 
      meta-analysis to better explore correlations between MTNR1B variants and T2DM. 
      METHODS: Literature research was performed in PubMed, Medline, and Embase. Odds 
      ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS: Totally 
      21 studies were enrolled to analyses. Pooled overall analyses showed that MTNR1B 
      rs10830963 variant was significantly correlated with the susceptibility to T2DM 
      (allele model: p = 0.02, OR = 0.97, 95% CI 0.95-1.00). Further subgroup analyses 
      by ethnicity of participants revealed that rs10830963 variant was significantly 
      correlated with the susceptibility to T2DM in South Asians, but not in Caucasians 
      or East Asians. No any other positive results were found in overall and subgroup 
      analyses. CONCLUSIONS: Our findings indicated that MTNR1B rs10830963 variant 
      might serve as a genetic biomarker of T2DM, especially in South Asians.
CI  - (c) 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley 
      Periodicals, Inc.
FAU - Shen, Ling-Long
AU  - Shen LL
AD  - Department of Clinical Laboratory, Huzhou Maternity and Child Health Care 
      Hospital, Huzhou, China.
FAU - Jin, Yin
AU  - Jin Y
AUID- ORCID: 0000-0002-9102-0650
AD  - Department of Clinical Laboratory, Huzhou Central Hospital, Huzhou, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20190227
PL  - United States
TA  - Mol Genet Genomic Med
JT  - Molecular genetics & genomic medicine
JID - 101603758
RN  - 0 (MTNR1B protein, human)
RN  - 0 (Receptor, Melatonin, MT2)
SB  - IM
MH  - Asian People/genetics
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Receptor, Melatonin, MT2/*genetics
PMC - PMC6503061
OTO - NOTNLM
OT  - genetic variants
OT  - melatonin receptor 1B (MTNR1B)
OT  - meta-analysis
OT  - type 2 diabetes mellitus (T2DM)
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/02/28 06:00
MHDA- 2019/06/27 06:00
PMCR- 2019/02/27
CRDT- 2019/02/28 06:00
PHST- 2018/12/18 00:00 [received]
PHST- 2019/01/25 00:00 [revised]
PHST- 2019/02/05 00:00 [accepted]
PHST- 2019/02/28 06:00 [pubmed]
PHST- 2019/06/27 06:00 [medline]
PHST- 2019/02/28 06:00 [entrez]
PHST- 2019/02/27 00:00 [pmc-release]
AID - MGG3611 [pii]
AID - 10.1002/mgg3.611 [doi]
PST - ppublish
SO  - Mol Genet Genomic Med. 2019 May;7(5):e611. doi: 10.1002/mgg3.611. Epub 2019 Feb 
      27.