PMID- 30813214
OWN - NLM
STAT- MEDLINE
DCOM- 20190306
LR  - 20200225
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 8
DP  - 2019 Feb
TI  - In-hospital, short-term and long-term adverse clinical outcomes observed in 
      patients with type 2 diabetes mellitus vs non-diabetes mellitus following 
      percutaneous coronary intervention: A meta-analysis including 139,774 patients.
PG  - e14669
LID - 10.1097/MD.0000000000014669 [doi]
LID - e14669
AB  - BACKGROUND: Several studies have shown that patients with type 2 diabetes 
      mellitus (T2DM) have worse clinical outcomes in comparison to patients without 
      diabetes mellitus (DM) following Percutaneous Coronary Intervention (PCI). 
      However, the adverse clinical outcomes were not similarly reported in all the 
      studies. Therefore, in order to standardize this issue, a meta-analysis including 
      139,774 patients was carried out to compare the in-hospital, short-term (<1 year) 
      and long-term (>/=1 year) adverse clinical outcomes in patients with and without 
      T2DM following PCI. METHODS: Electronic databases including MEDLINE, EMBASE, and 
      the Cochrane Library were searched for Randomized Controlled Trials (RCTs) and 
      observational studies. The adverse clinical outcomes which were analyzed included 
      mortality, myocardial infarction (MI), major adverse cardiac events (MACEs), 
      stroke, bleeding, target vessel revascularization (TVR), target lesion 
      revascularization (TLR), and stent thrombosis. Risk Ratios (RR) with 95% 
      confidence intervals (CI) were used to express the pooled effect on discontinuous 
      variables and the analysis was carried out by RevMan 5.3 software. RESULTS: A 
      total number of 139,774 participants were assessed. Results of this analysis 
      showed that in-hospital mortality and MACEs were significantly higher in patients 
      with T2DM (RR 2.57; 95% CI: 1.95-3.38; P = .00001) and (RR: 1.38; 95% CI: 
      1.10-1.73; P = .005) respectively. In addition, majority of the short and 
      long-term adverse clinical outcomes were also significantly higher in the DM 
      group as compared to the non-DM group. Stent thrombosis was significantly higher 
      in the DM compared to the non-DM group during the short term follow-up period (RR 
      1.59; 95% CI: 1.16-2.18;P = .004). However, long-term stent thrombosis was 
      similarly manifested. CONCLUSION: According to this meta-analysis including a 
      total number of 139,774 patients, following PCI, those patients with T2DM 
      suffered more in-hospital, short as well as long-term adverse outcomes as 
      reported by most of the Randomized Controlled Trials and Observational studies, 
      compared to those patients without diabetes mellitus.
FAU - Zhuo, Xiaojun
AU  - Zhuo X
AD  - Department of Cardiology, Affiliated Changsha Hospital of Hunan Normal 
      University, The Fourth Hospital of Changsha, Hunan, Changsha.
FAU - Zhang, Chuanzeng
AU  - Zhang C
AD  - State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai 
      University, the city of Tianjin, Tianjin, PR China.
FAU - Feng, Juan
AU  - Feng J
AD  - Department of Cardiology, Affiliated Changsha Hospital of Hunan Normal 
      University, The Fourth Hospital of Changsha, Hunan, Changsha.
FAU - Ouyang, Shenyu
AU  - Ouyang S
AD  - Department of Cardiology, Affiliated Changsha Hospital of Hunan Normal 
      University, The Fourth Hospital of Changsha, Hunan, Changsha.
FAU - Niu, Pei
AU  - Niu P
AD  - Department of Cardiology, Affiliated Changsha Hospital of Hunan Normal 
      University, The Fourth Hospital of Changsha, Hunan, Changsha.
FAU - Dai, Zhaohui
AU  - Dai Z
AD  - Department of Cardiology, Affiliated Changsha Hospital of Hunan Normal 
      University, The Fourth Hospital of Changsha, Hunan, Changsha.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - *Acute Coronary Syndrome/complications/surgery
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Hospital Mortality
MH  - Humans
MH  - *Long Term Adverse Effects/classification/mortality
MH  - Odds Ratio
MH  - Outcome Assessment, Health Care
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - *Postoperative Complications/classification/mortality
MH  - Stents/adverse effects
PMC - PMC6408074
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2019/03/01 06:00
MHDA- 2019/03/07 06:00
PMCR- 2019/02/22
CRDT- 2019/03/01 06:00
PHST- 2019/03/01 06:00 [entrez]
PHST- 2019/03/01 06:00 [pubmed]
PHST- 2019/03/07 06:00 [medline]
PHST- 2019/02/22 00:00 [pmc-release]
AID - 00005792-201902220-00094 [pii]
AID - MD-D-18-05606 [pii]
AID - 10.1097/MD.0000000000014669 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Feb;98(8):e14669. doi: 10.1097/MD.0000000000014669.