PMID- 30814581
OWN - NLM
STAT- MEDLINE
DCOM- 20200921
LR  - 20200921
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Feb 27
TI  - Therapeutic effect of topical administration of red onion extract in a murine 
      model of allergic rhinitis.
PG  - 2883
LID - 10.1038/s41598-019-39379-9 [doi]
LID - 2883
AB  - The aim of this study was to evaluate the effect of topical administration of 
      onion (Allium cepa) extract on nasal cavity for treatment of allergic rhinitis 
      (AR). BALB/c mice were sensitized by intraperitoneal injection of ovalbumin (OVA) 
      and challenged with intranasal instillation of OVA with or without onion extracts 
      for five times a week on 3 consecutive weeks. Allergic symptom score according to 
      frequencies of sneezing, serum total and OVA specific immunoglobulin E (IgE) 
      level, cytokine levels of nasal mucosa and eosinophilic infiltration were 
      analyzed. Allergic symptom score, serum total and OVA specific IgE, cytokine 
      levels of nasal mucosa (interleukin (IL)-4, IL-5, IL-10, IL-13, IFN-gamma, TNF-alpha and 
      COX-2) and eosinophilic infiltration were higher in allergic mouse group than 
      negative control group. Topical application of onion extracts significantly 
      reduced allergic symptoms and OVA specific IgE levels. Cytokine levels of IL-4, 
      IL-5, IL-10, IL-13 and IFN-gamma were significantly decreased in groups treated with 
      onion extract. In addition, eosinophil infiltration of nasal turbinate mucosa was 
      also significantly decreased after treatment with onion extract. Topical 
      administration of onion extract significantly reduces allergic rhinitis symptom 
      and allergic inflammatory reaction in a murine allergic model. It can be assumed 
      that the topical application of onion extract regulates allergic symptoms by 
      suppressing the type-1 helper (Th1) and type-2 helper (Th2) responses and 
      reducing the allergic inflammatory reaction.
FAU - Seo, Min Young
AU  - Seo MY
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Korea University 
      College of Medicine, Korea University Ansan Hospital, Ansan, South Korea.
FAU - Kim, Ki Ryung
AU  - Kim KR
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Lee, Jung Joo
AU  - Lee JJ
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Ryu, Gwanghui
AU  - Ryu G
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Lee, Seung Hoon
AU  - Lee SH
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Korea University 
      College of Medicine, Korea University Ansan Hospital, Ansan, South Korea.
FAU - Hong, Sang Duk
AU  - Hong SD
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Dhong, Hun-Jong
AU  - Dhong HJ
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Baek, Chung-Hwan
AU  - Baek CH
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Chung, Seung-Kyu
AU  - Chung SK
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Kim, Hyo Yeol
AU  - Kim HY
AUID- ORCID: 0000-0002-2162-3202
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 
      siamkhy@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190227
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - Cytokines/*blood
MH  - Eosinophils/*drug effects/immunology/metabolism
MH  - Female
MH  - Inflammation/immunology/pathology/*prevention & control
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Onions/*chemistry
MH  - Ovalbumin/toxicity
MH  - Plant Extracts/administration & dosage/*pharmacology
MH  - Rhinitis, Allergic/chemically induced/*drug therapy/immunology/pathology
PMC - PMC6393461
COIS- The authors declare no competing interests.
EDAT- 2019/03/01 06:00
MHDA- 2020/09/22 06:00
PMCR- 2019/02/27
CRDT- 2019/03/01 06:00
PHST- 2018/06/22 00:00 [received]
PHST- 2019/01/23 00:00 [accepted]
PHST- 2019/03/01 06:00 [entrez]
PHST- 2019/03/01 06:00 [pubmed]
PHST- 2020/09/22 06:00 [medline]
PHST- 2019/02/27 00:00 [pmc-release]
AID - 10.1038/s41598-019-39379-9 [pii]
AID - 39379 [pii]
AID - 10.1038/s41598-019-39379-9 [doi]
PST - epublish
SO  - Sci Rep. 2019 Feb 27;9(1):2883. doi: 10.1038/s41598-019-39379-9.