PMID- 30814933
OWN - NLM
STAT- MEDLINE
DCOM- 20190716
LR  - 20200309
IS  - 1662-5110 (Electronic)
IS  - 1662-5110 (Linking)
VI  - 13
DP  - 2019
TI  - A Temporal Filter for Binaural Hearing Is Dynamically Adjusted by Sound Pressure 
      Level.
PG  - 8
LID - 10.3389/fncir.2019.00008 [doi]
LID - 8
AB  - In natural environments our auditory system is exposed to multiple and diverse 
      signals of fluctuating amplitudes. Therefore, to detect, localize, and single out 
      individual sounds the auditory system has to process and filter spectral and 
      temporal information from both ears. It is known that the overall sound pressure 
      level affects sensory signal transduction and therefore the temporal response 
      pattern of auditory neurons. We hypothesize that the mammalian binaural system 
      utilizes a dynamic mechanism to adjust the temporal filters in neuronal circuits 
      to different overall sound pressure levels. Previous studies proposed an 
      inhibitory mechanism generated by the reciprocally coupled dorsal nuclei of the 
      lateral lemniscus (DNLL) as a temporal neuronal-network filter that suppresses 
      rapid binaural fluctuations. Here we investigated the consequence of different 
      sound levels on this filter during binaural processing. Our in vivo and in vitro 
      electrophysiology in Mongolian gerbils shows that the integration of ascending 
      excitation and contralateral inhibition defines the temporal properties of this 
      inhibitory filter. The time course of this filter depends on the synaptic drive, 
      which is modulated by the overall sound pressure level and N-methyl-D-aspartate 
      receptor (NMDAR) signaling. In psychophysical experiments we tested the temporal 
      perception of humans and show that detection and localization of two subsequent 
      tones changes with the sound pressure level consistent with our physiological 
      results. Together our data support the hypothesis that mammals dynamically adjust 
      their time window for sound detection and localization within the binaural system 
      in a sound level dependent manner.
FAU - Siveke, Ida
AU  - Siveke I
AD  - Department Biology II, Division of Neurobiology, Ludwig-Maximilians-Universitat 
      Munchen, Munich, Germany.
AD  - Institute of Zoology and Neurobiology, Ruhr-Universitat Bochum, Bochum, Germany.
FAU - Lingner, Andrea
AU  - Lingner A
AD  - Department Biology II, Division of Neurobiology, Ludwig-Maximilians-Universitat 
      Munchen, Munich, Germany.
FAU - Ammer, Julian J
AU  - Ammer JJ
AD  - Department Biology II, Division of Neurobiology, Ludwig-Maximilians-Universitat 
      Munchen, Munich, Germany.
AD  - Graduate School for Systemic Neurosciences, Ludwig-Maximilians-Universitat 
      Munchen, Munich, Germany.
FAU - Gleiss, Sarah A
AU  - Gleiss SA
AD  - Department Biology II, Division of Neurobiology, Ludwig-Maximilians-Universitat 
      Munchen, Munich, Germany.
AD  - Graduate School for Systemic Neurosciences, Ludwig-Maximilians-Universitat 
      Munchen, Munich, Germany.
FAU - Grothe, Benedikt
AU  - Grothe B
AD  - Department Biology II, Division of Neurobiology, Ludwig-Maximilians-Universitat 
      Munchen, Munich, Germany.
AD  - Graduate School for Systemic Neurosciences, Ludwig-Maximilians-Universitat 
      Munchen, Munich, Germany.
FAU - Felmy, Felix
AU  - Felmy F
AD  - Department Biology II, Division of Neurobiology, Ludwig-Maximilians-Universitat 
      Munchen, Munich, Germany.
AD  - Institute of Zoology, University of Veterinary Medicine Hannover, Hannover, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190213
PL  - Switzerland
TA  - Front Neural Circuits
JT  - Frontiers in neural circuits
JID - 101477940
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Quinoxalines)
RN  - 62T278S1MX (FG 9041)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - Acoustic Stimulation
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Auditory Pathways/physiology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Female
MH  - Gerbillinae
MH  - Hearing/*physiology
MH  - Inferior Colliculi/physiology
MH  - Male
MH  - Neural Inhibition
MH  - Neurons/drug effects
MH  - Psychophysics
MH  - Quinoxalines/pharmacology
MH  - *Sound
MH  - Sound Localization/*physiology
MH  - Time Factors
PMC - PMC6381077
OTO - NOTNLM
OT  - auditory filter
OT  - dorsal nucleus of the lateral lemniscus
OT  - echo perception
OT  - glutamate receptor
OT  - sound pressure level
EDAT- 2019/03/01 06:00
MHDA- 2019/07/17 06:00
PMCR- 2019/01/01
CRDT- 2019/03/01 06:00
PHST- 2018/09/27 00:00 [received]
PHST- 2019/01/24 00:00 [accepted]
PHST- 2019/03/01 06:00 [entrez]
PHST- 2019/03/01 06:00 [pubmed]
PHST- 2019/07/17 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fncir.2019.00008 [doi]
PST - epublish
SO  - Front Neural Circuits. 2019 Feb 13;13:8. doi: 10.3389/fncir.2019.00008. 
      eCollection 2019.