PMID- 30814948
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240409
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 11
DP  - 2019
TI  - Increases in a Pro-inflammatory Chemokine, MCP-1, Are Related to Decreases in 
      Memory Over Time.
PG  - 25
LID - 10.3389/fnagi.2019.00025 [doi]
LID - 25
AB  - Objective: To determine the longitudinal relationship between monocyte 
      chemotactic protein 1 (MCP-1)/CCL2 and memory function in older adults. Methods: 
      We examined longitudinal plasma MCP-1/CCL2 levels and a longitudinal verbal 
      memory measure (CVLT-II 20' recall) in a sample of 399 asymptomatic older adults 
      (mean age = 72.1). Total visits ranged from 1 to 8, with an average time of 2.1 
      years between each visit, yielding 932 total observations. In order to isolate 
      change over time, we decomposed MCP-1/CCL2 into subject-specific means and 
      longitudinal deviations from the mean. The decomposed MCP-1/CCL2 variables were 
      entered as predictors in linear mixed effects models, with age at baseline, sex, 
      and education entered as covariates and recall as the longitudinal outcome. In 
      follow-up analyses, we controlled for global cognition and APOE genotype, as well 
      as baseline vascular risk factors. We also examined the specificity of findings 
      by examining the longitudinal association between the MCP-1/CCL2 variables and 
      non-memory cognitive tests. Results: Within-subject increases in MCP-1/CCL2 
      levels were associated with decreases in delayed recall (t = -2.65; p = 0.01) 
      over time. Results were independent of global cognitive function and APOE status 
      (t = -2.30, p = 0.02), and effects remained when controlling for baseline 
      vascular risk factors (t = -1.92, p = 0.05). No associations were noted between 
      within-subject increases in MCP-1/CCL2 levels and other cognitive domains. 
      Conclusions: In an asymptomatic aging adult cohort, longitudinal increases in 
      MCP-1/CCL2 levels were associated with longitudinal decline in memory. Results 
      suggest that "healthy aging" is typified by early remodeling of the immune 
      system, and that the chemokine, MCP-1/CCL2, may be associated with negative 
      memory outcomes.
FAU - Bettcher, Brianne M
AU  - Bettcher BM
AD  - Rocky Mountain Alzheimer's Disease Center, Departments of Neurosurgery and 
      Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United 
      States.
FAU - Neuhaus, John
AU  - Neuhaus J
AD  - Department of Epidemiology and Biostatistics, University of California, San 
      Francisco, San Francisco, CA, United States.
FAU - Wynn, Matthew J
AU  - Wynn MJ
AD  - Department of Neurology, Memory and Aging Center, University of California, San 
      Francisco, San Francisco, CA, United States.
AD  - Department of Psychological and Brain Sciences, Washington University in St. 
      Louis, St. Louis, MO, United States.
FAU - Elahi, Fanny M
AU  - Elahi FM
AD  - Department of Neurology, Memory and Aging Center, University of California, San 
      Francisco, San Francisco, CA, United States.
FAU - Casaletto, Kaitlin B
AU  - Casaletto KB
AD  - Department of Neurology, Memory and Aging Center, University of California, San 
      Francisco, San Francisco, CA, United States.
FAU - Saloner, Rowan
AU  - Saloner R
AD  - Department of Psychiatry, San Diego State University/University of California San 
      Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, United 
      States.
AD  - HIV Neurobehavioral Research Program, Department of Psychiatry, University of 
      California, San Diego, San Diego, CA, United States.
FAU - Fitch, Ryan
AU  - Fitch R
AD  - Department of Neurology, Memory and Aging Center, University of California, San 
      Francisco, San Francisco, CA, United States.
FAU - Karydas, Anna
AU  - Karydas A
AD  - Department of Neurology, Memory and Aging Center, University of California, San 
      Francisco, San Francisco, CA, United States.
FAU - Kramer, Joel H
AU  - Kramer JH
AD  - Department of Neurology, Memory and Aging Center, University of California, San 
      Francisco, San Francisco, CA, United States.
LA  - eng
GR  - P50 AG023501/AG/NIA NIH HHS/United States
GR  - R01 AG048234/AG/NIA NIH HHS/United States
GR  - T32 AA013525/AA/NIAAA NIH HHS/United States
GR  - K23 AG042492/AG/NIA NIH HHS/United States
GR  - R01 AG032289/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20190213
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC6381047
OTO - NOTNLM
OT  - CCL2
OT  - chemokines
OT  - cognitive aging
OT  - inflammation
OT  - longitudinal
OT  - memory
EDAT- 2019/03/01 06:00
MHDA- 2019/03/01 06:01
PMCR- 2019/01/01
CRDT- 2019/03/01 06:00
PHST- 2018/11/26 00:00 [received]
PHST- 2019/01/29 00:00 [accepted]
PHST- 2019/03/01 06:00 [entrez]
PHST- 2019/03/01 06:00 [pubmed]
PHST- 2019/03/01 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2019.00025 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2019 Feb 13;11:25. doi: 10.3389/fnagi.2019.00025. 
      eCollection 2019.