PMID- 30815548
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2398-9238 (Electronic)
IS  - 2398-9238 (Linking)
VI  - 1
IP  - 2
DP  - 2018 Apr
TI  - Severity of hypoglycaemia and health-related quality of life, work productivity 
      and healthcare costs in patients with type 2 diabetes in Europe.
PG  - e00011
LID - 10.1002/edm2.11 [doi]
LID - e00011
AB  - AIMS: Hypoglycaemia in patients with type 2 diabetes mellitus (T2DM) is 
      associated with poor health outcomes, such as reduced health-related quality of 
      life (HRQoL). This study aimed to assess the impact of hypoglycaemic events by 
      severity on HRQoL, work productivity and healthcare costs in patients with T2DM. 
      MATERIALS AND METHODS: European patients with T2DM selected from the National 
      Health and Wellness Survey who were currently receiving pharmacologic therapy 
      were stratified into 3 groups based on the reported history and severity of 
      hypoglycaemic events (no event, nonsevere, severe) experienced in the previous 
      3 months. Patients' work productivity, HRQoL, healthcare resource use (HCRU) and 
      associated costs were assessed as self-reported outcomes. RESULTS: Of 1269 
      patients included in the study, 652 (51.4%) patients had not experienced an 
      event, while 533 (42.0%) and 84 (6.6%) patients had experienced nonsevere and 
      severe hypoglycaemic events, respectively, in the previous 3 months. An increase 
      in hypoglycaemia severity was associated with a decrease in HRQoL, and an 
      increase in HCRU and healthcare costs. CONCLUSIONS: The impact of hypoglycaemia 
      varies by severity and has a negative impact on HRQoL and overall HCRU and costs.
FAU - Pawaskar, Manjiri
AU  - Pawaskar M
AUID- ORCID: 0000-0001-8009-805X
AD  - Merck & Co. Inc. Kenilworth NJ USA.
FAU - Witt, Edward A
AU  - Witt EA
AD  - Kantar Health Princeton NJ USA.
FAU - Engel, Samuel S
AU  - Engel SS
AD  - Merck & Co. Inc. Kenilworth NJ USA.
FAU - Rajpathak, Swapnil N
AU  - Rajpathak SN
AD  - Merck & Co. Inc. Kenilworth NJ USA.
FAU - Iglay, Kristy
AU  - Iglay K
AD  - Merck & Co. Inc. Kenilworth NJ USA.
LA  - eng
PT  - Journal Article
DEP - 20180119
PL  - England
TA  - Endocrinol Diabetes Metab
JT  - Endocrinology, diabetes & metabolism
JID - 101732442
PMC - PMC6354814
OTO - NOTNLM
OT  - economic burden
OT  - healthcare resource use
OT  - health-related quality of life
OT  - hypoglycaemia
OT  - type 2 diabetes mellitus
OT  - work productivity
EDAT- 2019/03/01 06:00
MHDA- 2019/03/01 06:01
PMCR- 2018/01/19
CRDT- 2019/03/01 06:00
PHST- 2017/07/25 00:00 [received]
PHST- 2017/11/19 00:00 [revised]
PHST- 2017/12/03 00:00 [accepted]
PHST- 2019/03/01 06:00 [entrez]
PHST- 2019/03/01 06:00 [pubmed]
PHST- 2019/03/01 06:01 [medline]
PHST- 2018/01/19 00:00 [pmc-release]
AID - EDM211 [pii]
AID - 10.1002/edm2.11 [doi]
PST - epublish
SO  - Endocrinol Diabetes Metab. 2018 Jan 19;1(2):e00011. doi: 10.1002/edm2.11. 
      eCollection 2018 Apr.