PMID- 30816670
OWN - NLM
STAT- MEDLINE
DCOM- 20190308
LR  - 20190308
IS  - 1421-9778 (Electronic)
IS  - 1015-8987 (Linking)
VI  - 52
IP  - 2
DP  - 2019
TI  - The Effects of Adiponectin and Adiponectin Receptor 1 Levels on Macrovascular 
      Complications Among Patients with Type 2 Diabetes Mellitus.
PG  - 225-231
LID - 10.33594/000000016 [doi]
AB  - BACKGROUND/AIMS: The present study aimed to investigate the serum levels of 
      adiponectin (APN) and adiponectin receptor 1 (AdipoR1) in patients with type 2 
      diabetes mellitus (T2DM) combined with macrovascular complications (MVC), as well 
      as their correlation with clinical parameters. METHODS: A total of 60 T2DM 
      patients were divided into 2 groups according to the presence of MVC: T2DM + MVC 
      group (n=30) and T2DM group (n=30). Additionally, 30 healthy people were selected 
      as control group (NC group). Clinical data and biological parameters were 
      detected and recorded. T test was performed to compare the differences between 
      two groups, and the results were corrected using Bonferroni method. Meanwhile, 
      the correlation analysis and multiple stepwise regression analysis were used to 
      analyze the association of APN and AdipoR1 with clinical factors. RESULTS: The 
      levels of APN and AdipoR1 were significantly decreased in T2DM group and T2DM + 
      MVC group compared with NC group, with the lowest value in T2DM + MVC group (all 
      P<0.01). Serum APN levels were positively correlated with FINS and TG (r = 0.412, 
      0.316, respectively; both P<0.05), and negatively correlated with SBP, DBP and 
      LDL-C (r = -0.292, -0.383, -0.334, respectively; all P<0.05). Serum levels of 
      AdipoR1 were positively correlated with APN (r = 0.726, P<0.01), and negatively 
      correlated with BMI, SBP, DBP, FBG, TC and LDL-C (r = -0.440, -0.446, -0.374, 
      -0.444, -0.344, -0.709, respectively; all P<0.01). CONCLUSION: Serum levels of 
      APN and AdipoR1 are significantly lower in T2DM group and T2DM + MVC group, 
      showing lowest value in T2DM + MVC group. APN and AdipoR1 levels may influence 
      glucose and lipid metabolism in T2DM patients.
CI  - (c) Copyright by the Author(s). Published by Cell Physiol Biochem Press.
FAU - Su, Na
AU  - Su N
AD  - Department of Second Endocrinology, Cangzhou Central Hospital, Cangzhou, China, 
      sdourirr@163.com.
FAU - Zhao, Nairui
AU  - Zhao N
AD  - Department of Second Endocrinology, Cangzhou Central Hospital, Cangzhou, China.
FAU - Wang, Guangya
AU  - Wang G
AD  - Department of Second Endocrinology, Cangzhou Central Hospital, Cangzhou, China.
FAU - Wang, Linxia
AU  - Wang L
AD  - Department of Second Endocrinology, Cangzhou Central Hospital, Cangzhou, China.
FAU - Zhang, Yunna
AU  - Zhang Y
AD  - Department of Second Endocrinology, Cangzhou Central Hospital, Cangzhou, China.
FAU - Li, Ruijie
AU  - Li R
AD  - Department of Second Endocrinology, Cangzhou Central Hospital, Cangzhou, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Second Ultrasound, Cangzhou Central Hospital, Cangzhou, China.
FAU - Yang, Xinxin
AU  - Yang X
AD  - Department of Second Endocrinology, Cangzhou Central Hospital, Cangzhou, China.
FAU - Li, Cuiliu
AU  - Li C
AD  - Department of Second Endocrinology, Cangzhou Central Hospital, Cangzhou, China.
FAU - Hou, Mingming
AU  - Hou M
AD  - Department of Medical Records, Cangzhou Central Hospital, Cangzhou, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190228
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental 
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (ADIPOR1 protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Blood Glucose)
RN  - 0 (Receptors, Adiponectin)
SB  - IM
MH  - Adiponectin/*blood
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Angiopathies/*blood
MH  - Female
MH  - Humans
MH  - *Lipid Metabolism
MH  - Male
MH  - Middle Aged
MH  - Receptors, Adiponectin/*blood
OTO - NOTNLM
OT  - Adiponectin
OT  - Adiponectin receptor 1
OT  - Macrovascular complications
OT  - Type 2 diabetes mellitus
COIS- The authors declare to have no competing interests.
EDAT- 2019/03/01 06:00
MHDA- 2019/03/09 06:00
CRDT- 2019/03/01 06:00
PHST- 2018/01/06 00:00 [received]
PHST- 2019/02/22 00:00 [accepted]
PHST- 2019/03/01 06:00 [entrez]
PHST- 2019/03/01 06:00 [pubmed]
PHST- 2019/03/09 06:00 [medline]
AID - 10.33594/000000016 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 2019;52(2):225-231. doi: 10.33594/000000016. Epub 2019 Feb 
      28.