PMID- 30817818
OWN - NLM
STAT- MEDLINE
DCOM- 20200601
LR  - 20200601
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 104
IP  - 7
DP  - 2019 Jul 1
TI  - Compensatory Hippocampal Connectivity in Young Adults With Early-Stage Type 2 
      Diabetes.
PG  - 3025-3038
LID - 10.1210/jc.2018-02319 [doi]
AB  - CONTEXT: Middle-aged to elderly patients with type 2 diabetes mellitus (T2DM) 
      exhibit reduced functional connectivity and brain atrophy underlying cognitive 
      decrements; however, little is known about brain abnormalities in young patients. 
      OBJECTIVE: To detect brain anatomical and functional changes in young patients 
      with T2DM during the early disease stage. DESIGN: Case-control study. SETTING: 
      Tertiary referral hospital. PARTICIPANTS: Thirty-five young patients with T2DM 
      (<40 years of age) with no detectable microangiopathy and 32 nondiabetic control 
      subjects. INTERVENTION: None. MAIN OUTCOME MEASURES: Subjects underwent 
      neuropsychological assessments and structural and resting-state functional MRI. 
      Both voxel-based morphometry and resting-state functional connectivity analyses 
      were performed. RESULTS: No significant differences in brain volume were observed 
      between the patients with T2DM and the controls after controlling for age, sex, 
      education, and body mass index. Compared with the controls, the patients showed 
      greater connectivity of the left hippocampus with the left inferior frontal gyrus 
      and the left inferior parietal lobule. Moreover, the enhanced functional 
      connectivity of left hippocampus with the left inferior frontal gyrus 
      significantly correlated with disease severity (urinary albumin-to-creatinine 
      ratio) (r = 0.613, P < 0.001) and executive function (completion time of Stroop 
      Color and Word Test) (r = -0.461, P = 0.005) after false discovery rate 
      correction. CONCLUSIONS: Our findings suggest an adaptive compensation of brain 
      function to counteract the insidious cognitive decrements during the early stage 
      of T2DM. Additionally, the functional alterations occurring before changes in 
      brain structure and peripheral microangiopathy might serve as early biomarkers 
      related to cognitive decrements.
CI  - Copyright (c) 2019 Endocrine Society.
FAU - Fang, Fang
AU  - Fang F
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University, Shanghai, China.
FAU - Lai, Meng-Yu
AU  - Lai MY
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University, Shanghai, China.
FAU - Huang, Jing-Jing
AU  - Huang JJ
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University, Shanghai, China.
FAU - Kang, Mei
AU  - Kang M
AD  - Clinical Research Center, Shanghai General Hospital, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Ma, Ming-Ming
AU  - Ma MM
AD  - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center 
      for Visual Science and Photomedicine, Shanghai General Hospital, Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Li, Kang-An
AU  - Li KA
AD  - Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Lian, Jing-Ge
AU  - Lian JG
AD  - Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Wang, Zheng
AU  - Wang Z
AD  - Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy 
      of Sciences Center for Excellence in Brain Science and Intelligence Technology, 
      Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 
      Shanghai, China.
FAU - Yin, Da-Zhi
AU  - Yin DZ
AD  - Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy 
      of Sciences Center for Excellence in Brain Science and Intelligence Technology, 
      Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 
      Shanghai, China.
FAU - Wang, Yu-Fan
AU  - Wang YF
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - Adult
MH  - Brain/diagnostic imaging/pathology/physiopathology
MH  - Case-Control Studies
MH  - Cerebral Ventricles/diagnostic imaging/pathology
MH  - Diabetes Mellitus, Type 2/*physiopathology/psychology
MH  - Executive Function/physiology
MH  - Female
MH  - Functional Neuroimaging
MH  - Gray Matter/diagnostic imaging/pathology
MH  - Hippocampus/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Neuropsychological Tests
MH  - Organ Size
MH  - Parietal Lobe/*diagnostic imaging/physiopathology
MH  - Prefrontal Cortex/*diagnostic imaging/physiopathology
MH  - Severity of Illness Index
MH  - White Matter/diagnostic imaging/pathology
MH  - Young Adult
EDAT- 2019/03/01 06:00
MHDA- 2020/06/02 06:00
CRDT- 2019/03/01 06:00
PHST- 2018/10/27 00:00 [received]
PHST- 2019/02/25 00:00 [accepted]
PHST- 2019/03/01 06:00 [pubmed]
PHST- 2020/06/02 06:00 [medline]
PHST- 2019/03/01 06:00 [entrez]
AID - 5365820 [pii]
AID - 10.1210/jc.2018-02319 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2019 Jul 1;104(7):3025-3038. doi: 10.1210/jc.2018-02319.