PMID- 30820047 OWN - NLM STAT- MEDLINE DCOM- 20190424 LR - 20231104 IS - 1546-1718 (Electronic) IS - 1061-4036 (Print) IS - 1061-4036 (Linking) VI - 51 IP - 3 DP - 2019 Mar TI - Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing. PG - 414-430 LID - 10.1038/s41588-019-0358-2 [doi] AB - Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and Abeta processing are associated not only with early-onset autosomal dominant Alzheimer's disease but also with LOAD. Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 x 10(-7)), indicating that additional rare variants remain to be identified. We also identify important genetic correlations between LOAD and traits such as family history of dementia and education. FAU - Kunkle, Brian W AU - Kunkle BW AUID- ORCID: 0000-0002-9515-5157 AD - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu. FAU - Grenier-Boley, Benjamin AU - Grenier-Boley B AD - Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. AD - Institut Pasteur de Lille, Lille, France. AD - Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. FAU - Sims, Rebecca AU - Sims R AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. AD - UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK. FAU - Bis, Joshua C AU - Bis JC AD - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. FAU - Damotte, Vincent AU - Damotte V AD - Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. AD - Institut Pasteur de Lille, Lille, France. AD - Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. FAU - Naj, Adam C AU - Naj AC AD - Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Boland, Anne AU - Boland A AD - Centre National de Recherche en Genomique Humaine, Institut de Biologie Francois Jacob, CEA, Universite Paris-Saclay, and LabEx GENMED, Evry, France. FAU - Vronskaya, Maria AU - Vronskaya M AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - van der Lee, Sven J AU - van der Lee SJ AUID- ORCID: 0000-0003-1606-8643 AD - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. FAU - Amlie-Wolf, Alexandre AU - Amlie-Wolf A AUID- ORCID: 0000-0002-2073-1519 AD - Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Bellenguez, Celine AU - Bellenguez C AUID- ORCID: 0000-0002-1240-7874 AD - Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. AD - Institut Pasteur de Lille, Lille, France. AD - Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. FAU - Frizatti, Aura AU - Frizatti A AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - Chouraki, Vincent AU - Chouraki V AD - Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. AD - Institut Pasteur de Lille, Lille, France. AD - Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. AD - Framingham Heart Study, Framingham, MA, USA. AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. FAU - Martin, Eden R AU - Martin ER AD - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. FAU - Sleegers, Kristel AU - Sleegers K AUID- ORCID: 0000-0002-0283-2332 AD - Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium. AD - Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. FAU - Badarinarayan, Nandini AU - Badarinarayan N AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - Jakobsdottir, Johanna AU - Jakobsdottir J AD - Icelandic Heart Association, Kopavogur, Iceland. FAU - Hamilton-Nelson, Kara L AU - Hamilton-Nelson KL AD - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. FAU - Moreno-Grau, Sonia AU - Moreno-Grau S AD - Research Center and Memory Clinic of Fundacio ACE, Institut Catala de Neurociencies Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. FAU - Olaso, Robert AU - Olaso R AD - Centre National de Recherche en Genomique Humaine, Institut de Biologie Francois Jacob, CEA, Universite Paris-Saclay, and LabEx GENMED, Evry, France. FAU - Raybould, Rachel AU - Raybould R AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. AD - UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK. FAU - Chen, Yuning AU - Chen Y AUID- ORCID: 0000-0002-7358-7055 AD - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. FAU - Kuzma, Amanda B AU - Kuzma AB AD - Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Hiltunen, Mikko AU - Hiltunen M AD - Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. AD - Department of Neurology, Kuopio University Hospital, Kuopio, Finland. FAU - Morgan, Taniesha AU - Morgan T AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - Ahmad, Shahzad AU - Ahmad S AD - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. FAU - Vardarajan, Badri N AU - Vardarajan BN AD - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA. AD - Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA. AD - Department of Neurology, Columbia University, New York, NY, USA. FAU - Epelbaum, Jacques AU - Epelbaum J AD - UMR 894, Center for Psychiatry and Neuroscience, Inserm, Universite Paris Descartes, Paris, France. FAU - Hoffmann, Per AU - Hoffmann P AD - Institute of Human Genetics, University of Bonn, Bonn, Germany. AD - Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. AD - Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland. FAU - Boada, Merce AU - Boada M AD - Research Center and Memory Clinic of Fundacio ACE, Institut Catala de Neurociencies Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. FAU - Beecham, Gary W AU - Beecham GW AD - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. FAU - Garnier, Jean-Guillaume AU - Garnier JG AD - Centre National de Recherche en Genomique Humaine, Institut de Biologie Francois Jacob, CEA, Universite Paris-Saclay, and LabEx GENMED, Evry, France. FAU - Harold, Denise AU - Harold D AD - School of Biotechnology, Dublin City University, Dublin, Ireland. FAU - Fitzpatrick, Annette L AU - Fitzpatrick AL AD - Department of Family Medicine, University of Washington, Seattle, WA, USA. AD - Department of Epidemiology, University of Washington, Seattle, WA, USA. FAU - Valladares, Otto AU - Valladares O AD - Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Moutet, Marie-Laure AU - Moutet ML AD - Centre National de Recherche en Genomique Humaine, Institut de Biologie Francois Jacob, CEA, Universite Paris-Saclay, and LabEx GENMED, Evry, France. FAU - Gerrish, Amy AU - Gerrish A AD - Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. FAU - Smith, Albert V AU - Smith AV AD - Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. AD - Faculty of Medicine, University of Iceland, Reykjavik, Iceland. FAU - Qu, Liming AU - Qu L AD - Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Bacq, Delphine AU - Bacq D AD - Centre National de Recherche en Genomique Humaine, Institut de Biologie Francois Jacob, CEA, Universite Paris-Saclay, and LabEx GENMED, Evry, France. FAU - Denning, Nicola AU - Denning N AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. AD - UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK. FAU - Jian, Xueqiu AU - Jian X AD - Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA. FAU - Zhao, Yi AU - Zhao Y AD - Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Del Zompo, Maria AU - Del Zompo M AD - Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. FAU - Fox, Nick C AU - Fox NC AD - Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. AD - UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. FAU - Choi, Seung-Hoan AU - Choi SH AD - Research Center and Memory Clinic of Fundacio ACE, Institut Catala de Neurociencies Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain. FAU - Mateo, Ignacio AU - Mateo I AD - Neurology Service and CIBERNED, 'Marques de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain. FAU - Hughes, Joseph T AU - Hughes JT AD - Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Adams, Hieab H AU - Adams HH AUID- ORCID: 0000-0003-3687-2508 AD - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. FAU - Malamon, John AU - Malamon J AD - Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Sanchez-Garcia, Florentino AU - Sanchez-Garcia F AD - Department of Immunology, Hospital Universitario Doctor Negrin, Las Palmas de Gran Canaria, Spain. FAU - Patel, Yogen AU - Patel Y AD - Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Brody, Jennifer A AU - Brody JA AUID- ORCID: 0000-0001-8509-148X AD - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. FAU - Dombroski, Beth A AU - Dombroski BA AD - Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Naranjo, Maria Candida Deniz AU - Naranjo MCD AD - Department of Immunology, Hospital Universitario Doctor Negrin, Las Palmas de Gran Canaria, Spain. FAU - Daniilidou, Makrina AU - Daniilidou M AD - Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Eiriksdottir, Gudny AU - Eiriksdottir G AD - Icelandic Heart Association, Kopavogur, Iceland. FAU - Mukherjee, Shubhabrata AU - Mukherjee S AD - Department of Medicine, University of Washington, Seattle, WA, USA. FAU - Wallon, David AU - Wallon D AD - Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France. FAU - Uphill, James AU - Uphill J AD - Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK. FAU - Aspelund, Thor AU - Aspelund T AUID- ORCID: 0000-0002-7998-5433 AD - Icelandic Heart Association, Kopavogur, Iceland. AD - Centre for Public Health, University of Iceland, Reykjavik, Iceland. FAU - Cantwell, Laura B AU - Cantwell LB AD - Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Garzia, Fabienne AU - Garzia F AD - Centre National de Recherche en Genomique Humaine, Institut de Biologie Francois Jacob, CEA, Universite Paris-Saclay, and LabEx GENMED, Evry, France. FAU - Galimberti, Daniela AU - Galimberti D AD - Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy. AD - University of Milan, Centro Dino Ferrari, Milan, Italy. FAU - Hofer, Edith AU - Hofer E AD - Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria. AD - Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria. FAU - Butkiewicz, Mariusz AU - Butkiewicz M AD - Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. FAU - Fin, Bertrand AU - Fin B AD - Centre National de Recherche en Genomique Humaine, Institut de Biologie Francois Jacob, CEA, Universite Paris-Saclay, and LabEx GENMED, Evry, France. FAU - Scarpini, Elio AU - Scarpini E AD - Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy. AD - University of Milan, Centro Dino Ferrari, Milan, Italy. FAU - Sarnowski, Chloe AU - Sarnowski C AD - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. FAU - Bush, Will S AU - Bush WS AUID- ORCID: 0000-0002-9729-6519 AD - Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. FAU - Meslage, Stephane AU - Meslage S AD - Centre National de Recherche en Genomique Humaine, Institut de Biologie Francois Jacob, CEA, Universite Paris-Saclay, and LabEx GENMED, Evry, France. FAU - Kornhuber, Johannes AU - Kornhuber J AD - Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany. FAU - White, Charles C AU - White CC AD - Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. FAU - Song, Yuenjoo AU - Song Y AD - Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. FAU - Barber, Robert C AU - Barber RC AUID- ORCID: 0000-0001-6857-0286 AD - Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA. FAU - Engelborghs, Sebastiaan AU - Engelborghs S AD - Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. AD - Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium. FAU - Sordon, Sabrina AU - Sordon S AD - Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany. FAU - Voijnovic, Dina AU - Voijnovic D AD - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. FAU - Adams, Perrie M AU - Adams PM AD - Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Vandenberghe, Rik AU - Vandenberghe R AD - Laboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium. FAU - Mayhaus, Manuel AU - Mayhaus M AD - Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany. FAU - Cupples, L Adrienne AU - Cupples LA AUID- ORCID: 0000-0003-0273-7965 AD - Framingham Heart Study, Framingham, MA, USA. AD - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. FAU - Albert, Marilyn S AU - Albert MS AD - Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. FAU - De Deyn, Peter P AU - De Deyn PP AUID- ORCID: 0000-0002-2228-2964 AD - Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. AD - Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium. FAU - Gu, Wei AU - Gu W AD - Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany. FAU - Himali, Jayanadra J AU - Himali JJ AUID- ORCID: 0000-0003-1391-9481 AD - Framingham Heart Study, Framingham, MA, USA. AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. AD - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. FAU - Beekly, Duane AU - Beekly D AD - National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA. FAU - Squassina, Alessio AU - Squassina A AUID- ORCID: 0000-0001-7415-7607 AD - Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. FAU - Hartmann, Annette M AU - Hartmann AM AD - Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany. FAU - Orellana, Adelina AU - Orellana A AD - Research Center and Memory Clinic of Fundacio ACE, Institut Catala de Neurociencies Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain. FAU - Blacker, Deborah AU - Blacker D AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. AD - Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. FAU - Rodriguez-Rodriguez, Eloy AU - Rodriguez-Rodriguez E AD - Neurology Service and CIBERNED, 'Marques de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain. FAU - Lovestone, Simon AU - Lovestone S AD - Department of Psychiatry, University of Oxford, Oxford, UK. FAU - Garcia, Melissa E AU - Garcia ME AD - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA. FAU - Doody, Rachelle S AU - Doody RS AD - Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA. FAU - Munoz-Fernadez, Carmen AU - Munoz-Fernadez C AD - Department of Immunology, Hospital Universitario Doctor Negrin, Las Palmas de Gran Canaria, Spain. FAU - Sussams, Rebecca AU - Sussams R AD - Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK. FAU - Lin, Honghuang AU - Lin H AUID- ORCID: 0000-0003-3043-3942 AD - Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. FAU - Fairchild, Thomas J AU - Fairchild TJ AD - Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA. FAU - Benito, Yolanda A AU - Benito YA AD - Department of Immunology, Hospital Universitario Doctor Negrin, Las Palmas de Gran Canaria, Spain. FAU - Holmes, Clive AU - Holmes C AD - Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK. FAU - Karamujic-Comic, Hata AU - Karamujic-Comic H AD - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. FAU - Frosch, Matthew P AU - Frosch MP AD - C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA. FAU - Thonberg, Hakan AU - Thonberg H AD - Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden. AD - Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden. FAU - Maier, Wolfgang AU - Maier W AD - German Center for Neurodegenerative Diseases, Bonn, Germany. AD - Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. FAU - Roshchupkin, Gennady AU - Roshchupkin G AUID- ORCID: 0000-0002-3403-2313 AD - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. FAU - Ghetti, Bernardino AU - Ghetti B AUID- ORCID: 0000-0002-1842-8019 AD - Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA. FAU - Giedraitis, Vilmantas AU - Giedraitis V AUID- ORCID: 0000-0003-3423-2021 AD - Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden. FAU - Kawalia, Amit AU - Kawalia A AD - Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany. FAU - Li, Shuo AU - Li S AUID- ORCID: 0000-0003-2331-2448 AD - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. FAU - Huebinger, Ryan M AU - Huebinger RM AD - Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Kilander, Lena AU - Kilander L AD - Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden. FAU - Moebus, Susanne AU - Moebus S AD - Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany. FAU - Hernandez, Isabel AU - Hernandez I AD - Research Center and Memory Clinic of Fundacio ACE, Institut Catala de Neurociencies Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. FAU - Kamboh, M Ilyas AU - Kamboh MI AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. AD - Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. AD - Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. FAU - Brundin, RoseMarie AU - Brundin R AD - Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden. FAU - Turton, James AU - Turton J AD - Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK. FAU - Yang, Qiong AU - Yang Q AUID- ORCID: 0000-0002-3658-1375 AD - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. FAU - Katz, Mindy J AU - Katz MJ AD - Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. FAU - Concari, Letizia AU - Concari L AD - Section of Neuroscience, DIMEC-University of Parma, Parma, Italy. AD - FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy. FAU - Lord, Jenny AU - Lord J AD - Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK. FAU - Beiser, Alexa S AU - Beiser AS AD - Framingham Heart Study, Framingham, MA, USA. AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. AD - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. FAU - Keene, C Dirk AU - Keene CD AD - Department of Pathology, University of Washington, Seattle, WA, USA. FAU - Helisalmi, Seppo AU - Helisalmi S AD - Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. AD - Department of Neurology, Kuopio University Hospital, Kuopio, Finland. FAU - Kloszewska, Iwona AU - Kloszewska I AD - Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland. FAU - Kukull, Walter A AU - Kukull WA AD - Department of Epidemiology, University of Washington, Seattle, WA, USA. FAU - Koivisto, Anne Maria AU - Koivisto AM AD - Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. AD - Department of Neurology, Kuopio University Hospital, Kuopio, Finland. FAU - Lynch, Aoibhinn AU - Lynch A AD - Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland. AD - St. James's Hospital and Trinity College, Dublin, Ireland. FAU - Tarraga, Lluis AU - Tarraga L AD - Research Center and Memory Clinic of Fundacio ACE, Institut Catala de Neurociencies Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. FAU - Larson, Eric B AU - Larson EB AD - Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. FAU - Haapasalo, Annakaisa AU - Haapasalo A AD - A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. FAU - Lawlor, Brian AU - Lawlor B AD - Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland. AD - St. James's Hospital and Trinity College, Dublin, Ireland. FAU - Mosley, Thomas H AU - Mosley TH AD - Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA. FAU - Lipton, Richard B AU - Lipton RB AD - Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. FAU - Solfrizzi, Vincenzo AU - Solfrizzi V AD - Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy. FAU - Gill, Michael AU - Gill M AUID- ORCID: 0000-0003-0206-5337 AD - Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland. AD - St. James's Hospital and Trinity College, Dublin, Ireland. FAU - Longstreth, W T Jr AU - Longstreth WT Jr AD - Department of Epidemiology, University of Washington, Seattle, WA, USA. AD - Department of Neurology, University of Washington, Seattle, WA, USA. FAU - Montine, Thomas J AU - Montine TJ AD - Department of Pathology, University of Washington, Seattle, WA, USA. FAU - Frisardi, Vincenza AU - Frisardi V AD - Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy. FAU - Diez-Fairen, Monica AU - Diez-Fairen M AD - Fundacio per la Recerca Biomedica i Social Mutua Terrassa, Terrassa, Barcelona, Spain. AD - Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain. FAU - Rivadeneira, Fernando AU - Rivadeneira F AUID- ORCID: 0000-0001-9435-9441 AD - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. AD - Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands. AD - Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands. FAU - Petersen, Ronald C AU - Petersen RC AD - Department of Neurology, Mayo Clinic, Rochester, MN, USA. FAU - Deramecourt, Vincent AU - Deramecourt V AD - CHU Lille, Memory Center of Lille (Centre Memoire de Ressources et de Recherche), Lille, France. FAU - Alvarez, Ignacio AU - Alvarez I AD - Fundacio per la Recerca Biomedica i Social Mutua Terrassa, Terrassa, Barcelona, Spain. AD - Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain. FAU - Salani, Francesca AU - Salani F AD - Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy. FAU - Ciaramella, Antonio AU - Ciaramella A AD - Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy. FAU - Boerwinkle, Eric AU - Boerwinkle E AD - School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA. AD - Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. FAU - Reiman, Eric M AU - Reiman EM AD - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA. AD - Arizona Alzheimer's Consortium, Phoenix, AZ, USA. AD - Banner Alzheimer's Institute, Phoenix, AZ, USA. AD - Department of Psychiatry, University of Arizona, Phoenix, AZ, USA. FAU - Fievet, Nathalie AU - Fievet N AD - Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. AD - Institut Pasteur de Lille, Lille, France. AD - Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. FAU - Rotter, Jerome I AU - Rotter JI AD - Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. FAU - Reisch, Joan S AU - Reisch JS AD - Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Hanon, Olivier AU - Hanon O AD - University Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hopital Broca, Paris, France. FAU - Cupidi, Chiara AU - Cupidi C AD - Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy. FAU - Andre Uitterlinden, A G AU - Andre Uitterlinden AG AD - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. AD - Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands. AD - Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands. FAU - Royall, Donald R AU - Royall DR AD - Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA. FAU - Dufouil, Carole AU - Dufouil C AD - University of Bordeaux, Inserm 1219, Bordeaux, France. AD - Department of Neurology, Bordeaux University Hospital / CHU de Bordeaux, Bordeaux, France. FAU - Maletta, Raffaele Giovanni AU - Maletta RG AD - Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy. FAU - de Rojas, Itziar AU - de Rojas I AD - Research Center and Memory Clinic of Fundacio ACE, Institut Catala de Neurociencies Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. FAU - Sano, Mary AU - Sano M AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Brice, Alexis AU - Brice A AD - Inserm U1127, CNRS UMR 7225, Sorbonne Universites, UPMC Universite Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Epiniere, Paris, France. AD - AP-HP, Department of Genetics, Pitie-Salpetriere Hospital, Paris, France. FAU - Cecchetti, Roberta AU - Cecchetti R AD - Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. FAU - George-Hyslop, Peter St AU - George-Hyslop PS AD - Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. AD - Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada. FAU - Ritchie, Karen AU - Ritchie K AD - Inserm U1061 Neuropsychiatry, La Colombiere Hospital, Montpellier, France. AD - Montpellier University, Montpellier, France. AD - Department of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. FAU - Tsolaki, Magda AU - Tsolaki M AUID- ORCID: 0000-0002-2072-8010 AD - Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Tsuang, Debby W AU - Tsuang DW AD - VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA. AD - Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. FAU - Dubois, Bruno AU - Dubois B AD - Institut de la Memoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Epiniere, Departement de Neurologie, Hopital de la Pitie-Salpetriere, Paris, France. AD - Institut des Neurosciences Translationnelles de Paris, Institut du Cerveau et de la Moelle Epiniere, Paris, France. AD - Inserm, CNRS, UMR-S975, Institut du Cerveau et de la Moelle Epiniere, Paris, France. AD - Sorbonne Universites, Universite Pierre et Marie Curie, Hopital de la Pitie-Salpetriere, AP-HP, Paris, France. FAU - Craig, David AU - Craig D AD - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK. FAU - Wu, Chuang-Kuo AU - Wu CK AD - Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA. FAU - Soininen, Hilkka AU - Soininen H AD - Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. AD - Department of Neurology, Kuopio University Hospital, Kuopio, Finland. FAU - Avramidou, Despoina AU - Avramidou D AD - Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Albin, Roger L AU - Albin RL AD - Department of Neurology, University of Michigan, Ann Arbor, MI, USA. AD - Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, MI, USA. AD - Michigan Alzheimer Disease Center, Ann Arbor, MI, USA. FAU - Fratiglioni, Laura AU - Fratiglioni L AD - Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden. FAU - Germanou, Antonia AU - Germanou A AD - Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Apostolova, Liana G AU - Apostolova LG AD - Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA. AD - Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA. AD - Department of Neurology, Indiana University, Indianapolis, IN, USA. AD - Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA. FAU - Keller, Lina AU - Keller L AD - Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden. FAU - Koutroumani, Maria AU - Koutroumani M AD - Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Arnold, Steven E AU - Arnold SE AD - Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Panza, Francesco AU - Panza F AD - Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy. FAU - Gkatzima, Olymbia AU - Gkatzima O AD - Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Asthana, Sanjay AU - Asthana S AD - Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA. AD - Department of Medicine, University of Wisconsin, Madison, WI, USA. AD - Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA. FAU - Hannequin, Didier AU - Hannequin D AD - Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Whitehead, Patrice AU - Whitehead P AD - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. FAU - Atwood, Craig S AU - Atwood CS AUID- ORCID: 0000-0001-5040-1679 AD - Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA. AD - Department of Neurology, Indiana University, Indianapolis, IN, USA. AD - Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA. FAU - Caffarra, Paolo AU - Caffarra P AD - Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. AD - Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK. FAU - Hampel, Harald AU - Hampel H AD - AXA Research Fund & Sorbonne University Chair, Paris, France. AD - Sorbonne University, GRC n degrees 21, Alzheimer Precision Medicine (APM), AP-HP, Pitie-Salpetriere Hospital, Paris, France. AD - Brain & Spine Institute, Inserm U 1127, CNRS UMR 7225, Paris, France. AD - Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitie-Salpetriere Hospital, AP-HP, Paris, France. FAU - Quintela, Ines AU - Quintela I AD - Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigacion Biomedica en Red de Enfermedades Raras, Santiago de Compostela, Spain. FAU - Carracedo, Angel AU - Carracedo A AD - Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigacion Biomedica en Red de Enfermedades Raras, Santiago de Compostela, Spain. FAU - Lannfelt, Lars AU - Lannfelt L AD - Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden. FAU - Rubinsztein, David C AU - Rubinsztein DC AUID- ORCID: 0000-0001-5002-5263 AD - Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. AD - UK Dementia Research Institute, University of Cambridge, Cambridge, UK. FAU - Barnes, Lisa L AU - Barnes LL AD - Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. AD - Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA. AD - Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. FAU - Pasquier, Florence AU - Pasquier F AUID- ORCID: 0000-0001-9880-9788 AD - CHU Lille, Memory Center of Lille (Centre Memoire de Ressources et de Recherche), Lille, France. FAU - Frolich, Lutz AU - Frolich L AD - Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. FAU - Barral, Sandra AU - Barral S AD - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA. AD - Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA. AD - Department of Neurology, Columbia University, New York, NY, USA. FAU - McGuinness, Bernadette AU - McGuinness B AD - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK. FAU - Beach, Thomas G AU - Beach TG AD - Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA. FAU - Johnston, Janet A AU - Johnston JA AD - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK. FAU - Becker, James T AU - Becker JT AUID- ORCID: 0000-0003-4425-4726 AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. AD - Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. AD - Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Passmore, Peter AU - Passmore P AD - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK. FAU - Bigio, Eileen H AU - Bigio EH AD - Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. AD - Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Schott, Jonathan M AU - Schott JM AUID- ORCID: 0000-0003-2059-024X AD - Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. FAU - Bird, Thomas D AU - Bird TD AD - Department of Neurology, University of Washington, Seattle, WA, USA. AD - VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA. FAU - Warren, Jason D AU - Warren JD AD - Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. FAU - Boeve, Bradley F AU - Boeve BF AD - Department of Neurology, Mayo Clinic, Rochester, MN, USA. FAU - Lupton, Michelle K AU - Lupton MK AUID- ORCID: 0000-0002-7274-7299 AD - Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. AD - Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. FAU - Bowen, James D AU - Bowen JD AUID- ORCID: 0000-0002-4258-250X AD - Swedish Medical Center, Seattle, WA, USA. FAU - Proitsi, Petra AU - Proitsi P AD - Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Boxer, Adam AU - Boxer A AD - Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. FAU - Powell, John F AU - Powell JF AD - Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Burke, James R AU - Burke JR AUID- ORCID: 0000-0002-3408-7787 AD - Department of Neurology, Duke University, Durham, NC, USA. FAU - Kauwe, John S K AU - Kauwe JSK AD - Departments of Biology, Brigham Young University, Provo, UT, USA. FAU - Burns, Jeffrey M AU - Burns JM AD - University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA. FAU - Mancuso, Michelangelo AU - Mancuso M AUID- ORCID: 0000-0003-2738-8562 AD - Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy. FAU - Buxbaum, Joseph D AU - Buxbaum JD AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. AD - Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Bonuccelli, Ubaldo AU - Bonuccelli U AD - Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy. FAU - Cairns, Nigel J AU - Cairns NJ AD - Department of Pathology and Immunology, Washington University, St. Louis, MO, USA. FAU - McQuillin, Andrew AU - McQuillin A AUID- ORCID: 0000-0003-1567-2240 AD - Division of Psychiatry, University College London, London, UK. FAU - Cao, Chuanhai AU - Cao C AD - USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA. FAU - Livingston, Gill AU - Livingston G AD - Division of Psychiatry, University College London, London, UK. FAU - Carlson, Chris S AU - Carlson CS AD - Department of Medicine, University of Wisconsin, Madison, WI, USA. AD - Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA. FAU - Bass, Nicholas J AU - Bass NJ AD - Division of Psychiatry, University College London, London, UK. FAU - Carlsson, Cynthia M AU - Carlsson CM AD - Fred Hutchinson Cancer Research Center, Seattle, WA, USA. FAU - Hardy, John AU - Hardy J AD - Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK. FAU - Carney, Regina M AU - Carney RM AD - Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA. FAU - Bras, Jose AU - Bras J AD - UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. AD - Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. FAU - Carrasquillo, Minerva M AU - Carrasquillo MM AD - Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. FAU - Guerreiro, Rita AU - Guerreiro R AD - UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. AD - Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. FAU - Allen, Mariet AU - Allen M AD - Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. FAU - Chui, Helena C AU - Chui HC AD - Department of Neurology, University of Southern California, Los Angeles, CA, USA. FAU - Fisher, Elizabeth AU - Fisher E AUID- ORCID: 0000-0003-2850-9936 AD - Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. FAU - Masullo, Carlo AU - Masullo C AD - Department of Neurology, Catholic University of Rome, Rome, Italy. FAU - Crocco, Elizabeth A AU - Crocco EA AD - Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA. FAU - DeCarli, Charles AU - DeCarli C AD - Department of Neurology, University of California, Davis, Sacramento, CA, USA. FAU - Bisceglio, Gina AU - Bisceglio G AD - Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. FAU - Dick, Malcolm AU - Dick M AD - Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA. FAU - Ma, Li AU - Ma L AD - Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. FAU - Duara, Ranjan AU - Duara R AD - Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA. FAU - Graff-Radford, Neill R AU - Graff-Radford NR AD - Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. FAU - Evans, Denis A AU - Evans DA AD - Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA. FAU - Hodges, Angela AU - Hodges A AD - Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Faber, Kelley M AU - Faber KM AD - Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA. FAU - Scherer, Martin AU - Scherer M AD - Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. FAU - Fallon, Kenneth B AU - Fallon KB AD - Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. FAU - Riemenschneider, Matthias AU - Riemenschneider M AD - Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany. FAU - Fardo, David W AU - Fardo DW AUID- ORCID: 0000-0002-7207-4696 AD - Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA. FAU - Heun, Reinhard AU - Heun R AD - Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. FAU - Farlow, Martin R AU - Farlow MR AD - Department of Neurology, Indiana University, Indianapolis, IN, USA. FAU - Kolsch, Heike AU - Kolsch H AD - Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. FAU - Ferris, Steven AU - Ferris S AD - Department of Psychiatry, New York University, New York, NY, USA. FAU - Leber, Markus AU - Leber M AD - Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. FAU - Foroud, Tatiana M AU - Foroud TM AD - Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA. FAU - Heuser, Isabella AU - Heuser I AD - Department of Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany. FAU - Galasko, Douglas R AU - Galasko DR AD - Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. FAU - Giegling, Ina AU - Giegling I AD - Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany. FAU - Gearing, Marla AU - Gearing M AD - Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA. AD - Emory Alzheimer's Disease Center, Emory University, Atlanta, GA, USA. FAU - Hull, Michael AU - Hull M AD - Department of Psychiatry, University of Freiburg, Freiburg, Germany. FAU - Geschwind, Daniel H AU - Geschwind DH AD - Neurogenetics Program, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Gilbert, John R AU - Gilbert JR AD - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. FAU - Morris, John AU - Morris J AD - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. AD - Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA. FAU - Green, Robert C AU - Green RC AD - Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Mayo, Kevin AU - Mayo K AD - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. AD - Department of Neurology, Washington University, St. Louis, MO, USA. AD - Department of Genetics, Washington University, St. Louis, MO, USA. FAU - Growdon, John H AU - Growdon JH AD - Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. FAU - Feulner, Thomas AU - Feulner T AD - Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany. FAU - Hamilton, Ronald L AU - Hamilton RL AUID- ORCID: 0000-0002-6802-1102 AD - Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, USA. FAU - Harrell, Lindy E AU - Harrell LE AD - Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. FAU - Drichel, Dmitriy AU - Drichel D AD - Cologne Center for Genomics, University of Cologne, Cologne, Germany. FAU - Honig, Lawrence S AU - Honig LS AD - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA. FAU - Cushion, Thomas D AU - Cushion TD AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. AD - UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK. FAU - Huentelman, Matthew J AU - Huentelman MJ AD - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA. FAU - Hollingworth, Paul AU - Hollingworth P AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - Hulette, Christine M AU - Hulette CM AD - Department of Pathology, Duke University, Durham, NC, USA. FAU - Hyman, Bradley T AU - Hyman BT AD - Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. FAU - Marshall, Rachel AU - Marshall R AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - Jarvik, Gail P AU - Jarvik GP AD - Department of Genome Sciences, University of Washington, Seattle, WA, USA. AD - Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA. FAU - Meggy, Alun AU - Meggy A AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - Abner, Erin AU - Abner E AD - Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, KY, USA. FAU - Menzies, Georgina E AU - Menzies GE AUID- ORCID: 0000-0002-6600-6507 AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. AD - UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK. FAU - Jin, Lee-Way AU - Jin LW AD - Unidad Clinica de Enfermedades Infecciosas y Microbiologia, Hospital Universitario de Valme, Sevilla, Spain. FAU - Leonenko, Ganna AU - Leonenko G AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - Real, Luis M AU - Real LM AD - Unidad Clinica de Enfermedades Infecciosas y Microbiologia, Hospital Universitario de Valme, Sevilla, Spain. FAU - Jun, Gyungah R AU - Jun GR AD - Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. FAU - Baldwin, Clinton T AU - Baldwin CT AD - Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. FAU - Grozeva, Detelina AU - Grozeva D AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - Karydas, Anna AU - Karydas A AD - Swedish Medical Center, Seattle, WA, USA. FAU - Russo, Giancarlo AU - Russo G AD - Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland. FAU - Kaye, Jeffrey A AU - Kaye JA AD - Department of Neurology, Oregon Health &Science University, Portland, OR, USA. AD - Department of Neurology, Portland Veterans Affairs Medical Center, Portland, OR, USA. FAU - Kim, Ronald AU - Kim R AD - Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA. FAU - Jessen, Frank AU - Jessen F AD - German Center for Neurodegenerative Diseases, Bonn, Germany. AD - Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. AD - Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. FAU - Kowall, Neil W AU - Kowall NW AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. AD - Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA. FAU - Vellas, Bruno AU - Vellas B AD - Inserm U558, University of Toulouse, Toulouse, France. FAU - Kramer, Joel H AU - Kramer JH AD - Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA. FAU - Vardy, Emma AU - Vardy E AD - Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK. FAU - LaFerla, Frank M AU - LaFerla FM AD - Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA. FAU - Jockel, Karl-Heinz AU - Jockel KH AD - Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany. FAU - Lah, James J AU - Lah JJ AD - Department of Neurology, Emory University, Atlanta, GA, USA. FAU - Dichgans, Martin AU - Dichgans M AD - Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Munich, Germany. AD - German Center for Neurodegenerative Diseases, Munich, Germany. FAU - Leverenz, James B AU - Leverenz JB AD - Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA. FAU - Mann, David AU - Mann D AD - Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. FAU - Levey, Allan I AU - Levey AI AD - Department of Neurology, Emory University, Atlanta, GA, USA. FAU - Pickering-Brown, Stuart AU - Pickering-Brown S AUID- ORCID: 0000-0003-1561-6054 AD - Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. FAU - Lieberman, Andrew P AU - Lieberman AP AD - Department of Pathology, University of Michigan, Ann Arbor, MI, USA. FAU - Klopp, Norman AU - Klopp N AD - Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Munich, Germany. FAU - Lunetta, Kathryn L AU - Lunetta KL AUID- ORCID: 0000-0002-9268-810X AD - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. FAU - Wichmann, H-Erich AU - Wichmann HE AD - Helmholtz Center Munich, Institute of Epidemiology, Neuherberg, Munich, Germany. AD - Ludwig-Maximilians University Chair of Epidemiology, Munich, Germany. AD - Joint Biobank Munich and KORA Biobank, Baltimore, MD, USA. FAU - Lyketsos, Constantine G AU - Lyketsos CG AD - Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA. FAU - Morgan, Kevin AU - Morgan K AUID- ORCID: 0000-0002-8217-2396 AD - Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK. FAU - Marson, Daniel C AU - Marson DC AD - Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. FAU - Brown, Kristelle AU - Brown K AD - Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK. FAU - Martiniuk, Frank AU - Martiniuk F AD - Department of Medicine-Pulmonary, New York University, New York, NY, USA. FAU - Medway, Christopher AU - Medway C AD - Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK. FAU - Mash, Deborah C AU - Mash DC AD - Department of Neurology, University of Miami, Miami, FL, USA. FAU - Nothen, Markus M AU - Nothen MM AD - Institute of Human Genetics, University of Bonn, Bonn, Germany. AD - Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. FAU - Masliah, Eliezer AU - Masliah E AD - Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. AD - Department of Pathology, University of California, San Diego, La Jolla, CA, USA. FAU - Hooper, Nigel M AU - Hooper NM AUID- ORCID: 0000-0002-5811-3484 AD - Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. FAU - McCormick, Wayne C AU - McCormick WC AD - Department of Medicine, University of Washington, Seattle, WA, USA. FAU - Daniele, Antonio AU - Daniele A AD - Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy. FAU - McCurry, Susan M AU - McCurry SM AD - School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA. FAU - Bayer, Anthony AU - Bayer A AD - Institute of Primary Care and Public Health, Cardiff University, University Hospital of Wales, Cardiff, UK. FAU - McDavid, Andrew N AU - McDavid AN AUID- ORCID: 0000-0002-6581-1213 AD - USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA. FAU - Gallacher, John AU - Gallacher J AUID- ORCID: 0000-0002-2394-5299 AD - Department of Psychiatry, University of Oxford, Oxford, UK. FAU - McKee, Ann C AU - McKee AC AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. AD - Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA. FAU - van den Bussche, Hendrik AU - van den Bussche H AD - Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. FAU - Mesulam, Marsel AU - Mesulam M AD - Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. AD - Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Brayne, Carol AU - Brayne C AD - Cambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK. FAU - Miller, Bruce L AU - Miller BL AD - Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA. FAU - Riedel-Heller, Steffi AU - Riedel-Heller S AD - Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany. FAU - Miller, Carol A AU - Miller CA AD - Department of Pathology, University of Southern California, Los Angeles, CA, USA. FAU - Miller, Joshua W AU - Miller JW AD - Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA. FAU - Al-Chalabi, Ammar AU - Al-Chalabi A AUID- ORCID: 0000-0002-4924-7712 AD - Institute of Psychiatry, Psychology and Neuroscienceo, King's College London, London, UK. FAU - Morris, John C AU - Morris JC AD - Department of Pathology and Immunology, Washington University, St. Louis, MO, USA. AD - Department of Neurology, Washington University, St. Louis, MO, USA. FAU - Shaw, Christopher E AU - Shaw CE AD - Institute of Psychiatry, Psychology and Neuroscienceo, King's College London, London, UK. AD - UK Dementia Research Institute, King's College London, London, UK. FAU - Myers, Amanda J AU - Myers AJ AD - Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA. FAU - Wiltfang, Jens AU - Wiltfang J AD - Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany. AD - German Center for Neurodegenerative Diseases, Goettingen, Germany. AD - IBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal. FAU - O'Bryant, Sid AU - O'Bryant S AD - Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA. FAU - Olichney, John M AU - Olichney JM AD - Department of Neurology, University of California, Davis, Sacramento, CA, USA. FAU - Alvarez, Victoria AU - Alvarez V AD - Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain. FAU - Parisi, Joseph E AU - Parisi JE AD - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. FAU - Singleton, Andrew B AU - Singleton AB AD - Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. FAU - Paulson, Henry L AU - Paulson HL AD - Department of Neurology, University of Michigan, Ann Arbor, MI, USA. AD - Michigan Alzheimer Disease Center, Ann Arbor, MI, USA. FAU - Collinge, John AU - Collinge J AD - Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK. FAU - Perry, William R AU - Perry WR AD - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. FAU - Mead, Simon AU - Mead S AD - Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK. FAU - Peskind, Elaine AU - Peskind E AD - Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. FAU - Cribbs, David H AU - Cribbs DH AD - Department of Neurology, University of California, Irvine, Irvine, CA, USA. FAU - Rossor, Martin AU - Rossor M AD - Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. FAU - Pierce, Aimee AU - Pierce A AD - Department of Neurology, University of California, Irvine, Irvine, CA, USA. FAU - Ryan, Natalie S AU - Ryan NS AD - Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK. FAU - Poon, Wayne W AU - Poon WW AUID- ORCID: 0000-0003-0625-3968 AD - Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA. FAU - Nacmias, Benedetta AU - Nacmias B AD - Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy. AD - Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy. FAU - Potter, Huntington AU - Potter H AD - Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA. FAU - Sorbi, Sandro AU - Sorbi S AD - Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy. AD - IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy. FAU - Quinn, Joseph F AU - Quinn JF AD - Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. AD - Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. FAU - Sacchinelli, Eleonora AU - Sacchinelli E AUID- ORCID: 0000-0002-7648-5126 AD - Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy. FAU - Raj, Ashok AU - Raj A AD - USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA. FAU - Spalletta, Gianfranco AU - Spalletta G AD - Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy. AD - Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Raskind, Murray AU - Raskind M AD - Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. FAU - Caltagirone, Carlo AU - Caltagirone C AD - Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy. FAU - Bossu, Paola AU - Bossu P AD - Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy. FAU - Orfei, Maria Donata AU - Orfei MD AD - Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy. FAU - Reisberg, Barry AU - Reisberg B AD - Department of Psychiatry, New York University, New York, NY, USA. AD - Alzheimer's Disease Center, New York University, New York, NY, USA. FAU - Clarke, Robert AU - Clarke R AUID- ORCID: 0000-0002-9802-8241 AD - Oxford Healthy Aging Project, Clinical Trial Service Unit, University of Oxford, Oxford, UK. FAU - Reitz, Christiane AU - Reitz C AD - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA. AD - Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA. AD - Department of Epidemiology, Columbia University, New York, NY, USA. FAU - Smith, A David AU - Smith AD AD - Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK. FAU - Ringman, John M AU - Ringman JM AD - Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, Los Angeles, CA, USA. FAU - Warden, Donald AU - Warden D AD - Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK. FAU - Roberson, Erik D AU - Roberson ED AUID- ORCID: 0000-0002-1810-9763 AD - Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. FAU - Wilcock, Gordon AU - Wilcock G AD - Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK. FAU - Rogaeva, Ekaterina AU - Rogaeva E AD - Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada. FAU - Bruni, Amalia Cecilia AU - Bruni AC AD - Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy. FAU - Rosen, Howard J AU - Rosen HJ AD - Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. FAU - Gallo, Maura AU - Gallo M AD - Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy. FAU - Rosenberg, Roger N AU - Rosenberg RN AD - Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Ben-Shlomo, Yoav AU - Ben-Shlomo Y AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. FAU - Sager, Mark A AU - Sager MA AD - Department of Medicine, University of Wisconsin, Madison, WI, USA. FAU - Mecocci, Patrizia AU - Mecocci P AD - Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. FAU - Saykin, Andrew J AU - Saykin AJ AUID- ORCID: 0000-0002-1376-8532 AD - Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA. AD - Department of Neurology, Indiana University, Indianapolis, IN, USA. FAU - Pastor, Pau AU - Pastor P AUID- ORCID: 0000-0002-7493-8777 AD - Fundacio per la Recerca Biomedica i Social Mutua Terrassa, Terrassa, Barcelona, Spain. AD - Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain. FAU - Cuccaro, Michael L AU - Cuccaro ML AD - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. FAU - Vance, Jeffery M AU - Vance JM AD - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. FAU - Schneider, Julie A AU - Schneider JA AD - Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. AD - Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. AD - Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, USA. FAU - Schneider, Lori S AU - Schneider LS AD - Department of Neurology, University of Southern California, Los Angeles, CA, USA. AD - Department of Psychiatry, University of Southern California, Los Angeles, CA, USA. FAU - Slifer, Susan AU - Slifer S AD - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. FAU - Seeley, William W AU - Seeley WW AD - Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. FAU - Smith, Amanda G AU - Smith AG AD - USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA. FAU - Sonnen, Joshua A AU - Sonnen JA AD - Department of Pathology, University of Washington, Seattle, WA, USA. FAU - Spina, Salvatore AU - Spina S AD - Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA. FAU - Stern, Robert A AU - Stern RA AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. FAU - Swerdlow, Russell H AU - Swerdlow RH AD - University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA. FAU - Tang, Mitchell AU - Tang M AD - Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Tanzi, Rudolph E AU - Tanzi RE AUID- ORCID: 0000-0002-7032-1454 AD - Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. FAU - Trojanowski, John Q AU - Trojanowski JQ AD - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Troncoso, Juan C AU - Troncoso JC AD - Department of Pathology, Johns Hopkins University, Baltimore, MD, USA. FAU - Van Deerlin, Vivianna M AU - Van Deerlin VM AD - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Van Eldik, Linda J AU - Van Eldik LJ AD - Sanders-Brown Center on Aging, Department of Neuroscience, University of Kentucky, Lexington, KY, USA. FAU - Vinters, Harry V AU - Vinters HV AD - Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA. AD - Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Vonsattel, Jean Paul AU - Vonsattel JP AD - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, NY, USA. FAU - Weintraub, Sandra AU - Weintraub S AD - Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. AD - Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Welsh-Bohmer, Kathleen A AU - Welsh-Bohmer KA AD - Department of Neurology, Duke University, Durham, NC, USA. AD - Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA. FAU - Wilhelmsen, Kirk C AU - Wilhelmsen KC AD - Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. FAU - Williamson, Jennifer AU - Williamson J AD - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA. FAU - Wingo, Thomas S AU - Wingo TS AUID- ORCID: 0000-0002-7679-6282 AD - Department of Neurology, Emory University, Atlanta, GA, USA. AD - Department of Human Genetics, Emory University, Atlanta, GA, USA. FAU - Woltjer, Randall L AU - Woltjer RL AD - Department of Pathology, Oregon Health & Science University, Portland, OR, USA. FAU - Wright, Clinton B AU - Wright CB AD - National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. FAU - Yu, Chang-En AU - Yu CE AD - Department of Medicine, University of Washington, Seattle, WA, USA. FAU - Yu, Lei AU - Yu L AD - Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. AD - Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. FAU - Saba, Yasaman AU - Saba Y AD - Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria. FAU - Pilotto, Alberto AU - Pilotto A AD - Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy. AD - Department Geriatric Care, Orthogeriatrics and Rehabilitation, Galliera Hospital, Genova, Italy. FAU - Bullido, Maria J AU - Bullido MJ AUID- ORCID: 0000-0002-6477-1117 AD - Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. AD - IdiPAZ, Instituto de Investigacion Sanitaria la Paz, Madrid, Spain. AD - Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain. FAU - Peters, Oliver AU - Peters O AD - Department of Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany. AD - German Center for Neurodegenerative Diseases, Berlin, Germany. FAU - Crane, Paul K AU - Crane PK AD - Department of Medicine, University of Washington, Seattle, WA, USA. FAU - Bennett, David AU - Bennett D AD - Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. AD - Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. FAU - Bosco, Paola AU - Bosco P AD - Instituto di Ricovero e Cura a Carattere Scientifico, Associazione Oasi Maria Santissima Srl, Troina, Italy. FAU - Coto, Eliecer AU - Coto E AD - Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain. FAU - Boccardi, Virginia AU - Boccardi V AD - Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. FAU - De Jager, Phil L AU - De Jager PL AUID- ORCID: 0000-0002-8057-2505 AD - Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA. FAU - Lleo, Alberto AU - Lleo A AD - Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. AD - Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain. FAU - Warner, Nick AU - Warner N AD - Somerset Partnership NHS Trust, Somerset, UK. FAU - Lopez, Oscar L AU - Lopez OL AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. AD - Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. AD - Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. FAU - Ingelsson, Martin AU - Ingelsson M AD - Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden. FAU - Deloukas, Panagiotis AU - Deloukas P AUID- ORCID: 0000-0001-9251-070X AD - The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. FAU - Cruchaga, Carlos AU - Cruchaga C AUID- ORCID: 0000-0002-0276-2899 AD - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. AD - Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA. FAU - Graff, Caroline AU - Graff C AD - Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden. AD - Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden. FAU - Gwilliam, Rhian AU - Gwilliam R AD - The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. FAU - Fornage, Myriam AU - Fornage M AD - Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA. FAU - Goate, Alison M AU - Goate AM AUID- ORCID: 0000-0002-0576-2472 AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. AD - Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Sanchez-Juan, Pascual AU - Sanchez-Juan P AD - Neurology Service and CIBERNED, 'Marques de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain. FAU - Kehoe, Patrick G AU - Kehoe PG AD - University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK. FAU - Amin, Najaf AU - Amin N AD - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. FAU - Ertekin-Taner, Nilifur AU - Ertekin-Taner N AD - Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. AD - Department of Neurology, Mayo Clinic, Jacksonville, FL, USA. FAU - Berr, Claudine AU - Berr C AUID- ORCID: 0000-0001-5254-7655 AD - Inserm U1061 Neuropsychiatry, La Colombiere Hospital, Montpellier, France. AD - Montpellier University, Montpellier, France. FAU - Debette, Stephanie AU - Debette S AD - Inserm U1127, CNRS UMR 7225, Sorbonne Universites, UPMC Universite Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Epiniere, Paris, France. AD - AP-HP, Department of Genetics, Pitie-Salpetriere Hospital, Paris, France. FAU - Love, Seth AU - Love S AD - University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK. FAU - Launer, Lenore J AU - Launer LJ AD - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA. FAU - Younkin, Steven G AU - Younkin SG AD - Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. AD - Department of Neurology, Mayo Clinic, Jacksonville, FL, USA. FAU - Dartigues, Jean-Francois AU - Dartigues JF AD - Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France. FAU - Corcoran, Chris AU - Corcoran C AD - Utah State University, Logan, UT, USA. FAU - Ikram, M Arfan AU - Ikram MA AUID- ORCID: 0000-0003-0372-8585 AD - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. AD - Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. AD - Departments of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. FAU - Dickson, Dennis W AU - Dickson DW AUID- ORCID: 0000-0001-7189-7917 AD - Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. FAU - Nicolas, Gael AU - Nicolas G AD - Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France. FAU - Campion, Dominique AU - Campion D AD - Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France. AD - Department of Research Rouvray Psychiatric Hospital, Sotteville-les-Rouen, France. FAU - Tschanz, JoAnn AU - Tschanz J AD - Utah State University, Logan, UT, USA. FAU - Schmidt, Helena AU - Schmidt H AD - Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria. AD - Department of Neurology, Medical University Graz, Graz, Austria. FAU - Hakonarson, Hakon AU - Hakonarson H AD - Center for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. AD - Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Clarimon, Jordi AU - Clarimon J AD - Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. AD - Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain. FAU - Munger, Ron AU - Munger R AD - Utah State University, Logan, UT, USA. FAU - Schmidt, Reinhold AU - Schmidt R AD - Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria. FAU - Farrer, Lindsay A AU - Farrer LA AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. AD - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. AD - Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. AD - Department of Ophthalmology, Boston University School of Medicine, Boston University, Boston, MA, USA. AD - Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. FAU - Van Broeckhoven, Christine AU - Van Broeckhoven C AUID- ORCID: 0000-0003-0183-7665 AD - Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium. AD - Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. FAU - C O'Donovan, Michael AU - C O'Donovan M AUID- ORCID: 0000-0001-7073-2379 AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - DeStefano, Anita L AU - DeStefano AL AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. AD - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. FAU - Jones, Lesley AU - Jones L AUID- ORCID: 0000-0002-3007-4612 AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. AD - UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK. FAU - Haines, Jonathan L AU - Haines JL AD - Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. FAU - Deleuze, Jean-Francois AU - Deleuze JF AD - Centre National de Recherche en Genomique Humaine, Institut de Biologie Francois Jacob, CEA, Universite Paris-Saclay, and LabEx GENMED, Evry, France. FAU - Owen, Michael J AU - Owen MJ AUID- ORCID: 0000-0003-4798-0862 AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - Gudnason, Vilmundur AU - Gudnason V AD - Icelandic Heart Association, Kopavogur, Iceland. AD - Faculty of Medicine, University of Iceland, Reykjavik, Iceland. FAU - Mayeux, Richard AU - Mayeux R AD - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA. AD - Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA. AD - Department of Neurology, Columbia University, New York, NY, USA. FAU - Escott-Price, Valentina AU - Escott-Price V AUID- ORCID: 0000-0003-1784-5483 AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. AD - UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK. FAU - Psaty, Bruce M AU - Psaty BM AD - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. AD - Department of Epidemiology, University of Washington, Seattle, WA, USA. AD - Department of Health Services, University of Washington, Seattle, WA, USA. AD - Kaiser Permanente, Washington Health Research Institute, Seattle, WA, USA. FAU - Ramirez, Alfredo AU - Ramirez A AUID- ORCID: 0000-0003-4991-763X AD - Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany. AD - Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. FAU - Wang, Li-San AU - Wang LS AD - Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Ruiz, Agustin AU - Ruiz A AD - Research Center and Memory Clinic of Fundacio ACE, Institut Catala de Neurociencies Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. FAU - van Duijn, Cornelia M AU - van Duijn CM AD - Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. FAU - Holmans, Peter A AU - Holmans PA AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. FAU - Seshadri, Sudha AU - Seshadri S AD - Framingham Heart Study, Framingham, MA, USA. AD - Department of Neurology, Boston University School of Medicine, Boston, MA, USA. AD - Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA. FAU - Williams, Julie AU - Williams J AD - Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. AD - UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK. FAU - Amouyel, Phillippe AU - Amouyel P AUID- ORCID: 0000-0001-9088-234X AD - Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. AD - Institut Pasteur de Lille, Lille, France. AD - Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. AD - Centre Hospitalier Universitaire de Lille, Lille, France. FAU - Schellenberg, Gerard D AU - Schellenberg GD AD - Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Lambert, Jean-Charles AU - Lambert JC AUID- ORCID: 0000-0003-0829-7817 AD - Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. jean-charles.lambert@pasteur-lille.fr. AD - Institut Pasteur de Lille, Lille, France. jean-charles.lambert@pasteur-lille.fr. AD - Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. jean-charles.lambert@pasteur-lille.fr. FAU - Pericak-Vance, Margaret A AU - Pericak-Vance MA AUID- ORCID: 0000-0001-7283-8804 AD - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. mpericak@miami.edu. CN - Alzheimer Disease Genetics Consortium (ADGC), CN - European Alzheimer's Disease Initiative (EADI), CN - Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), CN - Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer's Disease Consortium (GERAD/PERADES), LA - eng GR - P01 AG017586/AG/NIA NIH HHS/United States GR - U01 AG032984/AG/NIA NIH HHS/United States GR - MR/M024784/1/MRC_/Medical Research Council/United Kingdom GR - P30 AG010161/AG/NIA NIH HHS/United States GR - G0500289/MRC_/Medical Research Council/United Kingdom GR - R01 AG018454/AG/NIA NIH HHS/United States GR - P30 AG013854/AG/NIA NIH HHS/United States GR - P30 AG053760/AG/NIA NIH HHS/United States GR - R01 AG054060/AG/NIA NIH HHS/United States GR - P30 AG010124/AG/NIA NIH HHS/United States GR - MR/N012453/1/MRC_/Medical Research Council/United Kingdom GR - MR/K01417X/1/MRC_/Medical Research Council/United Kingdom GR - R01 NS017950/NS/NINDS NIH HHS/United States GR - MR/L501529/1/MRC_/Medical Research Council/United Kingdom GR - U01 AG032438/AG/NIA NIH HHS/United States GR - G0902227/MRC_/Medical Research Council/United Kingdom GR - R01 AG054076/AG/NIA NIH HHS/United States GR - R01 HL120393/HL/NHLBI NIH HHS/United States GR - MR/L023784/1/MRC_/Medical Research Council/United Kingdom GR - P50 AG005142/AG/NIA NIH HHS/United States GR - MC_PC_18025/MRC_/Medical Research Council/United Kingdom GR - 203249/Z/16/Z/WT_/Wellcome Trust/United Kingdom GR - MR/L021803/1/MRC_/Medical Research Council/United Kingdom GR - MC_UU_00024/9/MRC_/Medical Research Council/United Kingdom GR - U24 AG021886/AG/NIA NIH HHS/United States GR - MR/L501542/1/MRC_/Medical Research Council/United Kingdom GR - UL1 TR002369/TR/NCATS NIH HHS/United States GR - MR/M009076/1/MRC_/Medical Research Council/United Kingdom GR - MC_PC_14095/MRC_/Medical Research Council/United Kingdom GR - U01 HL120393/HL/NHLBI NIH HHS/United States GR - MR/L010305/1/MRC_/Medical Research Council/United Kingdom GR - MC_UU_00024/1/MRC_/Medical Research Council/United Kingdom GR - U01 AG016976/AG/NIA NIH HHS/United States GR - P01 AG003991/AG/NIA NIH HHS/United States GR - P50 AG005681/AG/NIA NIH HHS/United States GR - G0801418/MRC_/Medical Research Council/United Kingdom GR - G-0907/PUK_/Parkinson's UK/United Kingdom GR - U24 AG056270/AG/NIA NIH HHS/United States GR - P01 AG026276/AG/NIA NIH HHS/United States GR - R01 AG017917/AG/NIA NIH HHS/United States GR - K25 AG055620/AG/NIA NIH HHS/United States GR - RF1 AG054023/AG/NIA NIH HHS/United States GR - P30 AG017266/AG/NIA NIH HHS/United States GR - R01 HL105756/HL/NHLBI NIH HHS/United States GR - MR/N026004/1/MRC_/Medical Research Council/United Kingdom GR - RF1 AG051504/AG/NIA NIH HHS/United States GR - MR/K013041/1/MRC_/Medical Research Council/United Kingdom GR - P01 AG019724/AG/NIA NIH HHS/United States GR - G9810900/MRC_/Medical Research Council/United Kingdom GR - R01 AG061796/AG/NIA NIH HHS/United States GR - G0600237/MRC_/Medical Research Council/United Kingdom GR - G0300429/MRC_/Medical Research Council/United Kingdom GR - G0600974/MRC_/Medical Research Council/United Kingdom GR - MR/R024804/1/MRC_/Medical Research Council/United Kingdom GR - R01 AG041232/AG/NIA NIH HHS/United States GR - UL1 TR001414/TR/NCATS NIH HHS/United States GR - ALCHALABI-DOBSON/APR14/829-791/MNDA_/Motor Neurone Disease Association/United Kingdom GR - U01 AG052409/AG/NIA NIH HHS/United States GR - U01 AG046139/AG/NIA NIH HHS/United States GR - RF1 AG015473/AG/NIA NIH HHS/United States GR - P30 AG010129/AG/NIA NIH HHS/United States GR - SHAW/NOV14/985-797/MNDA_/Motor Neurone Disease Association/United Kingdom GR - MR/L023784/2/MRC_/Medical Research Council/United Kingdom GR - G0701075/MRC_/Medical Research Council/United Kingdom GR - G0901254/MRC_/Medical Research Council/United Kingdom GR - G0900688/MRC_/Medical Research Council/United Kingdom GR - MR/L501517/1/MRC_/Medical Research Council/United Kingdom GR - MC_U123160657/MRC_/Medical Research Council/United Kingdom GR - R01 AG015819/AG/NIA NIH HHS/United States GR - G0900421/MRC_/Medical Research Council/United Kingdom GR - U01 AG049505/AG/NIA NIH HHS/United States PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't DEP - 20190228 PL - United States TA - Nat Genet JT - Nature genetics JID - 9216904 RN - 0 (Amyloid beta-Peptides) RN - 0 (Lipids) RN - 0 (tau Proteins) SB - IM EIN - Nat Genet. 2019 Sep;51(9):1423-1424. PMID: 31417202 CIN - Cardiovasc Res. 2019 Sep 1;115(11):e102-e104. PMID: 31436832 MH - Aged MH - Alzheimer Disease/*genetics MH - Amyloid beta-Peptides/*genetics MH - Case-Control Studies MH - Female MH - Genetic Loci/*genetics MH - Genetic Predisposition to Disease/*genetics MH - Genetic Testing/methods MH - Genome-Wide Association Study/methods MH - Haplotypes/genetics MH - Humans MH - Immunity/*genetics MH - Lipid Metabolism/genetics MH - Lipids/*genetics MH - Male MH - tau Proteins/*genetics PMC - PMC6463297 MID - NIHMS1021255 COIS- Competing interests D. Blacker is a consultant for Biogen, Inc. R.C.P. is a consultant for Roche, Inc.; Merck, Inc.; Genentech, Inc.; Biogen, Inc.; GE Healthcare; and Eisai, Inc. A.R.W. is a former employee and stockholder of Pfizer, Inc., and a current employee of the Perelman School of Medicine at the University of Pennsylvania Orphan Disease Center in partnership with the Loulou. A.M.G. is a member of the scientific advisory board for Denali Therapeutics. N.E.-T. is a consultant for Cytox. J.Hardy holds a collaborative grant with Cytox cofunded by the Department of Business (Biz). F.J. acts as a consultant for Novartis, Eli Lilly, Nutricia, MSD, Roche and Piramal. Neither J.M. nor his family owns stock or has equity interest (outside of mutual funds or other externally directed accounts) in any pharmaceutical or biotechnology company. J.M. is currently participating in clinical trials of antidementia drugs from Eli Lilly and Company, Biogen and Janssen. J.M. serves as a consultant for Lilly USA. He receives research support from Eli Lilly/Avid Radiopharmaceuticals and is funded by NIH grant nos. P50AG005681, P01AG003991, P01AG026276 and UF01AG032438. C.Cruchaga receives research support from Biogen, EISAI, Alector and Parabon. The funders of the study had no role in the collection, analysis or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. C.Cruchaga is a member of the advisory board of ADx Healthcare. M.R.F. receives grant/research support from AbbVie, Accera, ADCS Posiphen, Biogen, Eisai, Eli Lilly, Genentech, Novartis and Suven Life Sciences, Ltd. He is a consultant/advisory board/DSMB board member for Accera, Avanir, AZTherapies, Cognition Therapeutics, Cortexyme, Eli Lilly & Company, Longeveron, Medavante, Merck and Co. Inc., Otsuka Pharmaceutical, Proclara (formerly Neurophage Pharmaceuticals), Neurotrope Biosciences, Takeda, vTv Therapeutics and Zhejian Hisun Pharmaceuticals. He has a transgenic mouse model patent that is licensed to Elan. R.A.S. receives consulting fees as a member of the Alzheimer's Disease Advisory Board, Biogen; and as member of the Executive Committee for AZD3293 Alzheimer's Disease Studies, Eli Lilly. R.B.L. receives consulting fees from Merch, Inc. E.M.R. receives grant funding from several NIH grant and research contracts with Genentech/Roche, Novartis/ Amgen and Avid/Lilly. He is a compensated scientific advisor to Alkahest, Alzheon, Aural Analytics, Denali, Takeda and Zinfandel. He is an advisor to Roche and Roche Diagnostics, which reimburse his expenses only. T.G.B. has research support/contracts from the National Institutes of Health, State of Arizona, Michael J Fox Foundation, Avid Radiopharmaceuticals, Navida Biopharmaceuticals and Aprinoia Therapeutics. He is an advisory board member with Vivid Genomics and has consultancy work with Roche Diagnostics. A.G.S. conducts multiple industry-funded clinical trials, but all funds go to her academic institution. They have current (within last 12 months) research contracts with Eli Lilly, Novartis, Roche, Janssen, AbbVie, Biogen, NeuroEM, Suven and Merck. She does not receive personal compensations from these organizations. G.D.S. is a consultant for Biogen, Inc. J.M.B. is participating in clinical trials of antidementia drugs for Eli Lilly, Toyama Chemical Company, Merck, Biogen, AbbVie, vTv Therapeutics, Janssen and Roche. He has received research grants from Eli Lilly, Avid Radiopharmaceuticals and Astra Zeneca. He is a consultant for Stage 2 Innovations. L.F. is a consultant for Allergan, Eli Lilly, Avraham Pharmaceuticals, Axon Neuroscience, Axovant, Biogen, Boehringer Ingelheim, Eisai, Functional Neuromodulation, Lundbeck, MerckSharpe & Dohme, Novartis, Pfizer, Pharnext, Roche and Schwabe Pharma. M.B has consulted as an advisory board member for Araclon, Grifols, Lilly, Nutricia, Roche and Servier. She received fees for lectures and funds for research from Araclon, Grifols, Nutricia, Roche and Servier. She has not received personal compensations from these organizations. A.Ruiz has consulted for Grifols and Landsteiner Genmed. He received fees for lectures or funds for research and/or reimbursement of expenses for congresses attendance from Araclon and Grifols. He has not received personal compensations from these organizations. O.P. acts as a consultant for Roche and Biogen, Inc. He is currently participating in clinical trials of antidementia drugs from Novartis, Genentech, Roche and Pharmatrophix. B.T.H. is a consultant for Aztherapy, Biogen, Calico, Ceregene, Genentech, Lilly, Neurophage, Novartis and Takeda, and receives research support from Abbvie, Amgen, Deanli, Fidelity Biosciences, General Electric, Lilly, Merck, Sangamo and Spark therapeutics. BTH owns Novartis stock. H.Hampel serves as Senior Associate Editor for the Journal Alzheimer's & Dementia; he received lecture fees from Biogen and Roche, research grants from Pfizer, Avid and MSD AVENIR (paid to the institution), travel funding from Functional Neuromodulation, Axovant, Eli Lilly and company, Takeda and Zinfandel, GE Healthcare and Oryzon Genomics, consultancy fees from Jung Diagnostics, Cytox Ltd., Axovant, Anavex, Takeda and Zinfandel, GE Healthcare, Oryzon Genomics and Functional Neuromodulation, and participated in scientific advisory boards of Functional Neuromodulation, Axovant, Eli Lilly and company, Cytox Ltd., GE Healthcare, Takeda and Zinfandel, Oryzon Genomics and Roche Diagnostica. Harald Hampel is a co-inventor on numerous patents relating to biomarker measurement but has received no royalties from these patents. A.A.-C. has consultancies for GSK, Cytokinetics, Biogen Idec, Treeway Inc, Chronos Therapeutics, OrionPharma and Mitsubishi-Tanabe Pharma, and was Chief Investigator for commercial clinical trials run by OrionPharma and Cytokinetics. EDAT- 2019/03/02 06:00 MHDA- 2019/04/25 06:00 PMCR- 2020/03/01 CRDT- 2019/03/02 06:00 PHST- 2018/03/12 00:00 [received] PHST- 2019/01/22 00:00 [accepted] PHST- 2019/03/02 06:00 [entrez] PHST- 2019/03/02 06:00 [pubmed] PHST- 2019/04/25 06:00 [medline] PHST- 2020/03/01 00:00 [pmc-release] AID - 10.1038/s41588-019-0358-2 [pii] AID - 10.1038/s41588-019-0358-2 [doi] PST - ppublish SO - Nat Genet. 2019 Mar;51(3):414-430. doi: 10.1038/s41588-019-0358-2. Epub 2019 Feb 28.