PMID- 30821002
OWN - NLM
STAT- MEDLINE
DCOM- 20200619
LR  - 20200619
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 33
IP  - 4
DP  - 2019 Apr
TI  - Which is the best predictor of de novo donor-specific antibodies in a cohort of 
      non-sensitized first kidney transplantation: Antigenic, allelic, epitope, or 
      physiochemical HLA mismatches?
PG  - e13508
LID - 10.1111/ctr.13508 [doi]
AB  - BACKGROUND: Assessment of human leukocyte antigen (HLA) matching by using 
      high-resolution allele typing and knowledge of HLA molecule structure may lead to 
      better prediction of de novo donor-specific antibody (dnDSA) development. 
      METHODS: We conducted a single-center cohort study among 150 non-sensitized first 
      kidney transplant recipients to compare the association between antigenic (Ag), 
      allelic (Al), eplet (Ep), amino acid (AAMS) HLA matching and electrostatic (EMS) 
      and hydrophobic (HMS) mismatch scores, and the development of dnDSA. RESULTS: 
      After a mean follow-up time of 49.3 +/- 17.7 months, 18 patients (12%) developed 
      dnDSA. The number of HLA mismatches (MM) was significantly associated with the 
      development of dnDSA. The optimal threshold, determined by Harrell's C-index, 
      varied according to the method (5 MM for Ag, P = 0.006; 6 for Al, P = 0.009; 22 
      for Ep, P = 0.005; 42 for AAMS, P = 0.0007; 45 for EMS, P = 0.009 and 44 for HMS, 
      P = 0.026). C-indices were similar for all matching approaches, suggesting a 
      similar prediction of dnDSA development. CONCLUSION: In this cohort of low 
      immunological risk transplant patients, the use of Al or Ep matching did not 
      improve the prediction of dnDSA development in comparison with the traditional 
      approach.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Delion, Alexandra
AU  - Delion A
AD  - Service de Nephrologie et Transplantation renale, CHRU Nancy Brabois, 
      Vandoeuvre-les-Nancy, France.
FAU - Girerd, Sophie
AU  - Girerd S
AUID- ORCID: 0000-0001-9303-7184
AD  - Service de Nephrologie et Transplantation renale, CHRU Nancy Brabois, 
      Vandoeuvre-les-Nancy, France.
AD  - INSERM, Centre d'Investigations Cliniques Plurithematique 1433, Universite de 
      Lorraine, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France.
FAU - Duarte, Kevin
AU  - Duarte K
AD  - INSERM, Centre d'Investigations Cliniques Plurithematique 1433, Universite de 
      Lorraine, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France.
FAU - Girerd, Nicolas
AU  - Girerd N
AD  - INSERM, Centre d'Investigations Cliniques Plurithematique 1433, Universite de 
      Lorraine, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France.
FAU - Schikowski, Johan
AU  - Schikowski J
AD  - Service de Nephrologie et Transplantation renale, CHRU Nancy Brabois, 
      Vandoeuvre-les-Nancy, France.
FAU - Kessler, Michele
AU  - Kessler M
AD  - Service de Nephrologie et Transplantation renale, CHRU Nancy Brabois, 
      Vandoeuvre-les-Nancy, France.
FAU - Frimat, Luc
AU  - Frimat L
AD  - Service de Nephrologie et Transplantation renale, CHRU Nancy Brabois, 
      Vandoeuvre-les-Nancy, France.
FAU - Aarnink, Alice
AU  - Aarnink A
AUID- ORCID: 0000-0001-9550-5383
AD  - Laboratoire d'Histocompatibilite, CHRU Nancy Brabois, Vandoeuvre-les-Nancy, 
      France.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20190322
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Cohort Studies
MH  - Epitopes/*immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Survival/*immunology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Isoantibodies/*immunology
MH  - Kidney Transplantation/*methods
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Factors
MH  - Tissue Donors/*supply & distribution
OTO - NOTNLM
OT  - HLA
OT  - donor-specific antibody
OT  - epitope mismatches
OT  - kidney transplantation
OT  - physiochemical properties
EDAT- 2019/03/02 06:00
MHDA- 2020/06/20 06:00
CRDT- 2019/03/02 06:00
PHST- 2018/06/25 00:00 [received]
PHST- 2019/01/11 00:00 [revised]
PHST- 2019/01/28 00:00 [accepted]
PHST- 2019/03/02 06:00 [pubmed]
PHST- 2020/06/20 06:00 [medline]
PHST- 2019/03/02 06:00 [entrez]
AID - 10.1111/ctr.13508 [doi]
PST - ppublish
SO  - Clin Transplant. 2019 Apr;33(4):e13508. doi: 10.1111/ctr.13508. Epub 2019 Mar 22.