PMID- 30823424
OWN - NLM
STAT- MEDLINE
DCOM- 20190619
LR  - 20200225
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 24
IP  - 5
DP  - 2019 Feb 28
TI  - Anti-Inflammation Effect of Small Molecule Oligopeptides Prepared from Panax 
      ginseng C. A. Meyer in Rats.
LID - 10.3390/molecules24050858 [doi]
LID - 858
AB  - The present study was designed to investigate the anti-inflammatory effects of 
      ginseng oligopeptides (GOPs). For the anti-inflammatory activity, dextran-induced 
      paw edema and granuloma models were used in Sprague-Dawley rats (180(-)200 g, 12 
      weeks old, n = 10). Rats were treated orally with GOPs (0, 62.5, 125, 250 and 500 
      mg/kg) for prophylaxis. In the granuloma model, the levels of NO, Tumor necrosis 
      factor-alpha (TNF-alpha), interleukin IL-beta, and interleukin IL-10 in serum were 
      evaluated. In addition, in the edema model, the level of TNF-alpha, prostaglandin E2 
      (PGE2), Leukotriene D4 (LTD4), and the platelet activating factor (RAF) in paw 
      tissue were detected. PCR assessed the effect of GOPs on the expression of MAPK 
      and NF-kappaB. The results showed that oral administration of GOPs inhibited 
      inflammation caused by cotton pellet and dextran. GOPs significantly inhibited 
      the edema formation via MAPK and NF-kappaB. These findings suggested that GOPs have a 
      beneficial effect on acute and chronic inflammation, and the mechanism possibly 
      mediated by inhibiting gene expression involved in inflammation and 
      downregulating inflammatory mediators.
FAU - Xu, Meihong
AU  - Xu M
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. xumeihong@bjmu.edu.cn.
FAU - Chen, Qihe
AU  - Chen Q
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. qiheyuntian@163.com.
FAU - Fan, Rui
AU  - Fan R
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. fanruirf@bjmu.edu.cn.
FAU - Wang, Junbo
AU  - Wang J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. Mrwang4j@163.com.
FAU - Li, Yong
AU  - Li Y
AUID- ORCID: 0000-0003-3914-5840
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. liyongbmu@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190228
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 0 (Plant Proteins)
SB  - IM
MH  - Animals
MH  - *Anti-Inflammatory Agents/chemistry/pharmacology
MH  - Cytokines/metabolism
MH  - Edema/chemically induced/*drug therapy/metabolism/pathology
MH  - Granuloma/chemically induced/*drug therapy/metabolism/pathology
MH  - Male
MH  - Panax/*chemistry
MH  - Plant Extracts/*chemistry
MH  - *Plant Proteins/chemistry/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC6429476
OTO - NOTNLM
OT  - Panax ginseng
OT  - cotton pellet-induced
OT  - dextran
OT  - inflammation
OT  - oligopeptide
COIS- The authors declare no conflict of interest.
EDAT- 2019/03/03 06:00
MHDA- 2019/06/20 06:00
PMCR- 2019/02/28
CRDT- 2019/03/03 06:00
PHST- 2018/12/29 00:00 [received]
PHST- 2019/02/24 00:00 [revised]
PHST- 2019/02/26 00:00 [accepted]
PHST- 2019/03/03 06:00 [entrez]
PHST- 2019/03/03 06:00 [pubmed]
PHST- 2019/06/20 06:00 [medline]
PHST- 2019/02/28 00:00 [pmc-release]
AID - molecules24050858 [pii]
AID - molecules-24-00858 [pii]
AID - 10.3390/molecules24050858 [doi]
PST - epublish
SO  - Molecules. 2019 Feb 28;24(5):858. doi: 10.3390/molecules24050858.