PMID- 30823641 OWN - NLM STAT- MEDLINE DCOM- 20190702 LR - 20200309 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 16 IP - 5 DP - 2019 Mar 1 TI - Allergen Sensitization and Asthma Outcomes among World Trade Center Rescue and Recovery Workers. LID - 10.3390/ijerph16050737 [doi] LID - 737 AB - A large number of World Trade Center (WTC) rescue and recovery workers are affected by asthma. While physical and mental health comorbidities have been associated with poor asthma control in this population, the potential role of allergen sensitization is unknown. This study examined the association of indoor sensitization and exposure as a risk factor for increased asthma morbidity in WTC workers. We used data from a prospective cohort of 331 WTC workers with asthma. Sensitization to indoor allergens was assessed by measurement of antigen-specific serum immunoglobulin E (IgE) levels. We used validated tools to evaluate the exposure to indoor allergens. Asthma morbidity outcomes included level of control (Asthma Control Questionnaire, ACQ), quality of life (Asthma Quality of Life Questionnaire, AQLQ) and acute resource utilization. The prevalence of sensitization to cat, dog, mouse, dust mite, cockroach, and mold allergens were 33%, 21%, 17%, 40%, 17%, and 17%, respectively. Unadjusted and regression analyses showed no significant relationship between sensitization and increased asthma morbidity (p > 0.05 for all comparisons), except for sensitization to Aspergillus Fumigatus, cat and mouse epithelium, which were associated with decreased morbidity. FAU - Rojano, Belen AU - Rojano B AUID- ORCID: 0000-0002-7376-1826 AD - Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. belen.rojanobroz@mountsinai.org. FAU - West, Erin AU - West E AUID- ORCID: 0000-0001-7339-3819 AD - Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. krystallyn@gmail.com. FAU - Ferdermann, Emily AU - Ferdermann E AUID- ORCID: 0000-0001-9625-1688 AD - Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. emily.federmann@mountsinai.org. FAU - Markowitz, Steven AU - Markowitz S AD - Barry Commoner Center for Health and the Environment, Queens College, City University of New York, Queens, New York, NY 11367, USA. steven.markowitz@qc.cuny.edu. FAU - Harrison, Denise AU - Harrison D AD - Department of Medicine, New York University School of Medicine, Bellevue Hospital Center, New York, NY 10016, USA. denise.harrison@nyulangone.org. FAU - Crowley, Laura AU - Crowley L AD - Division of Occupational and Environmental Medicine, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. laura.crowley@mssm.edu. FAU - Busse, Paula AU - Busse P AD - Division of Allergy and Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. paula.busse@mssm.edu. FAU - Federman, Alex D AU - Federman AD AD - Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. alex.federman@mountsinai.org. FAU - Wisnivesky, Juan P AU - Wisnivesky JP AD - Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. juan.wisnivesky@mssm.edu. AD - Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. juan.wisnivesky@mssm.edu. LA - eng GR - U01 OH010405/OH/NIOSH CDC HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. DEP - 20190301 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 RN - 0 (Allergens) SB - IM MH - Allergens/*immunology MH - Animals MH - Asthma/epidemiology/*etiology MH - Cockroaches/immunology MH - Cohort Studies MH - *Environmental Exposure MH - Female MH - Health Resources MH - Humans MH - Male MH - Morbidity MH - Prevalence MH - Prospective Studies MH - Pyroglyphidae/immunology MH - Quality of Life MH - *Rescue Work MH - Risk Factors MH - *September 11 Terrorist Attacks PMC - PMC6427816 OTO - NOTNLM OT - WTC-related asthma OT - World Trade Center OT - allergen exposure OT - asthma control OT - asthma morbidity OT - asthma outcomes OT - asthma quality of life OT - immunoglobulin E OT - indoor allergens sensitization OT - mini asthma quality of life questionnaire COIS- Wisnivesky has received a consultant honorarium from Merck, Astra Zeneca, and Quintiles, and research grants from Sanofi and Quorum. Busse received a grant and honorarium from Shire and honorarium from Behring, Pharming, Pearl Therapeutics, Biocryst, CVS Health, and GSK. The other authors have no conflict of interest to report. EDAT- 2019/03/03 06:00 MHDA- 2019/07/03 06:00 PMCR- 2019/03/01 CRDT- 2019/03/03 06:00 PHST- 2019/01/15 00:00 [received] PHST- 2019/02/15 00:00 [revised] PHST- 2019/02/22 00:00 [accepted] PHST- 2019/03/03 06:00 [entrez] PHST- 2019/03/03 06:00 [pubmed] PHST- 2019/07/03 06:00 [medline] PHST- 2019/03/01 00:00 [pmc-release] AID - ijerph16050737 [pii] AID - ijerph-16-00737 [pii] AID - 10.3390/ijerph16050737 [doi] PST - epublish SO - Int J Environ Res Public Health. 2019 Mar 1;16(5):737. doi: 10.3390/ijerph16050737.