PMID- 30823942
OWN - NLM
STAT- MEDLINE
DCOM- 20190627
LR  - 20190627
IS  - 1681-7168 (Electronic)
IS  - 1022-386X (Linking)
VI  - 29
IP  - 3
DP  - 2019 Mar
TI  - Hypertensive Retinopathy: A Prognostic Factor for Morbidity and Mortality after 
      Acute ST Elevation Myocardial Infarction.
PG  - 205-209
LID - 10.29271/jcpsp.2019.03.205 [doi]
AB  - OBJECTIVE: To determine the association between hypertensive retinopathy (HR) and 
      post ST elevation myocardial infarction (STEMI) complications among successfully 
      thrombolysed patients. STUDY DESIGN: A cohort study. PLACE AND DURATION OF STUDY: 
      Cardiology Unit, Lady Reading Hospital, Peshawar, from June 2016 to December 
      2017. METHODOLOGY: Patients with history of hypertension for at least 5 years who 
      presented with STEMI and were successfully thrombolysed, were included. On the 
      basis of fundoscopy, patients were grouped into no, mild, moderate, and severe 
      hypertensive retinopathy. Primary and secondary endpoints included a composite of 
      death, re-MI, stroke, re-hospitalisation secondary to left ventricular failure, 
      cardiogenic shock, arrhythmia, heart block, and ventricular septal rupture at 30 
      days and 4 months, respectively. Association between hypertensive retinopathy and 
      post STEMI complications was determined by Chi-square test. Regression model was 
      used to calculate relative risk of complications with hypertensive retinopathy. P 
      <0.05 was taken as significant. RESULTS: A total of 118 patients with a mean age 
      of 54.83 +/-8.6 years were included in the study. Of these, 49.2% (n=58) were 
      males. Moreover, 38.1% (n=45) of patients were grouped under no HR, 22.8% (n=27) 
      under mild HR, 21.1% (n=25) and 17.7% (n=21) under moderate and severe HR, 
      respectively. Primary endpoints achieved were 0% in no HR group and 19% in severe 
      HR group x(2) = 18.1, p <0.001). Secondary endpoints were achieved in 2.2% in no HR 
      group and 40.7%, 56% and 100% in mild, moderate and severe HR group, 
      respectively, ( x(2) = 81.1, p <0.001). HR also increased the relative risk of 
      complications by 3.17 times (p <0.001) and death by 1.75 times (p <0.001). 
      CONCLUSION: Hypertensive retinopathy is an independent risk factor for post-acute 
      STEMI complications in successfully thrombolysed patients and increased the 
      relative risk for complications by 3.17 times.
FAU - Jibran, Muhammad Saad
AU  - Jibran MS
AD  - Cardiology Unit, Lady Reading Hospital, Peshawar, Pakistan.
FAU - Habib, Syed Abid
AU  - Habib SA
AD  - Cardiology Unit, Lady Reading Hospital, Peshawar, Pakistan.
FAU - Khan, Sher Bahadar
AU  - Khan SB
AD  - Cardiology Unit, Lady Reading Hospital, Peshawar, Pakistan.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
SB  - IM
MH  - Acute Disease
MH  - Age Distribution
MH  - Aged
MH  - *Cause of Death
MH  - Chi-Square Distribution
MH  - Cohort Studies
MH  - Comorbidity
MH  - Female
MH  - Heart Block/diagnosis/epidemiology
MH  - Heart Failure/diagnosis/*epidemiology
MH  - Humans
MH  - Hypertensive Retinopathy/diagnosis/*epidemiology/therapy
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Pakistan
MH  - Percutaneous Coronary Intervention/methods
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - ST Elevation Myocardial Infarction/diagnosis/*epidemiology/therapy
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - Shock, Cardiogenic/diagnosis/*epidemiology
MH  - Survival Rate
MH  - Ventricular Septal Rupture/diagnosis/*epidemiology
EDAT- 2019/03/03 06:00
MHDA- 2019/06/30 06:00
CRDT- 2019/03/03 06:00
PHST- 2018/04/03 00:00 [received]
PHST- 2018/11/12 00:00 [accepted]
PHST- 2019/03/03 06:00 [entrez]
PHST- 2019/03/03 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
AID - 040579197 [pii]
AID - 10.29271/jcpsp.2019.03.205 [doi]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2019 Mar;29(3):205-209. doi: 
      10.29271/jcpsp.2019.03.205.