PMID- 30824230
OWN - NLM
STAT- MEDLINE
DCOM- 20190715
LR  - 20190715
IS  - 1095-8320 (Electronic)
IS  - 1045-1056 (Linking)
VI  - 58
DP  - 2019 Mar
TI  - Down-regulation of miR-122 after transplantation of mesenchymal stem cells in 
      acute liver failure in mice model.
PG  - 64-72
LID - S1045-1056(18)30091-5 [pii]
LID - 10.1016/j.biologicals.2019.02.002 [doi]
AB  - This study investigated the correlation between the hepatic level of miR-122 and 
      the extent of liver tissue regeneration in CCl(4) induced liver injury mice model 
      following transplantation of menstrual blood-(MenSCs) and bone marrow-derived 
      stem cells (BMSCs). Hepatic miR-122 levels were significantly up-regulated 
      following administration of CCl(4) (P < 0.01). The significant positive 
      correlations were observed between hepatic miR-122 and biochemical serum markers 
      and the severity of liver injury in histopathological assessments (P < 0.01). 
      Following stem cell therapy, all cell treated groups showed a significant 
      down-regulation in miR-122 that was significantly correlated with improvement in 
      histopathological features and biochemical markers (P < 0.01). Furthermore, the 
      hepatic level of miR-122 was lower in the MenSCs-treated group compared with the 
      BMSCs-treated group (P < 0.01) and in HPL cells-treated groups in reference to 
      undifferentiated cells-treated groups (P < 0.05). These data suggest that miR-122 
      could be used as a potential predictor of outcome of liver injury after 
      mesenchymal stem cell transplantation.
CI  - Copyright (c) 2019 International Alliance for Biological Standardization. Published 
      by Elsevier Ltd. All rights reserved.
FAU - Fathi-Kazerooni, Mina
AU  - Fathi-Kazerooni M
AD  - Department of Molecular Medicine, School of Advanced Technologies in Medicine, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Kazemnejad, Somaieh
AU  - Kazemnejad S
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, 
      Tehran, Iran.
FAU - Khanjani, Sayeh
AU  - Khanjani S
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, 
      Tehran, Iran.
FAU - Saltanatpour, Zohreh
AU  - Saltanatpour Z
AD  - Department of Molecular Medicine, School of Advanced Technologies in Medicine, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Tavoosidana, Gholamreza
AU  - Tavoosidana G
AD  - Department of Molecular Medicine, School of Advanced Technologies in Medicine, 
      Tehran University of Medical Sciences, Tehran, Iran. Electronic address: 
      g-tavoosi@tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20190226
PL  - England
TA  - Biologicals
JT  - Biologicals : journal of the International Association of Biological 
      Standardization
JID - 9004494
RN  - 0 (MicroRNAs)
RN  - 0 (Mirn122 microRNA, mouse)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Disease Models, Animal
MH  - *Down-Regulation
MH  - Female
MH  - Heterografts
MH  - Humans
MH  - *Liver Failure, Acute/metabolism/pathology/therapy
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - MicroRNAs/*biosynthesis
OTO - NOTNLM
OT  - Bone marrow stem cells
OT  - Liver injury
OT  - Menstrual blood stem cells
OT  - Micro-RNA
OT  - Regenerative medicine
EDAT- 2019/03/03 06:00
MHDA- 2019/07/16 06:00
CRDT- 2019/03/03 06:00
PHST- 2018/04/14 00:00 [received]
PHST- 2018/11/28 00:00 [revised]
PHST- 2019/02/19 00:00 [accepted]
PHST- 2019/03/03 06:00 [pubmed]
PHST- 2019/07/16 06:00 [medline]
PHST- 2019/03/03 06:00 [entrez]
AID - S1045-1056(18)30091-5 [pii]
AID - 10.1016/j.biologicals.2019.02.002 [doi]
PST - ppublish
SO  - Biologicals. 2019 Mar;58:64-72. doi: 10.1016/j.biologicals.2019.02.002. Epub 2019 
      Feb 26.