PMID- 30825784
OWN - NLM
STAT- MEDLINE
DCOM- 20190924
LR  - 20190925
IS  - 1095-8630 (Electronic)
IS  - 0301-4797 (Linking)
VI  - 237
DP  - 2019 May 1
TI  - A review of toxicity induced by persistent organic pollutants (POPs) and 
      endocrine-disrupting chemicals (EDCs) in the nematode Caenorhabditis elegans.
PG  - 519-525
LID - S0301-4797(19)30262-2 [pii]
LID - 10.1016/j.jenvman.2019.02.102 [doi]
AB  - Persistent organic pollutants (POPs) and endocrine disrupting compounds (EDCs) 
      are almost ubiquitous in synthetic and natural sources; however these 
      contaminants adversely impact ecosystems and humans. Owing to their potential 
      toxicity, concerns have been raised about the effects of POPs and EDCs on 
      ecological and human health. Therefore, toxicity evaluation and mechanisms 
      actions of these contaminants are of great interest. The nematode Caenorhabditis 
      elegans (C. elegans), an excellent model animal for environmental toxicology 
      research, has been used widely for toxicity studies of POPs or EDCs from the 
      whole-animal level to the single-cell level. In this review, we have discussed 
      the toxicity of specific POPs or EDCs after acute, chronic, and multigenerational 
      exposure in C. elegans. We have also introduced a discussion of the toxicological 
      mechanisms of these compounds in C. elegans, with respect to oxidative stress, 
      cell apoptosis, and the insulin/IGF-1 signaling pathway. Finally, we raised 
      considered the perspectives and challenges of the toxicity assessments, 
      multigenerational toxicity, and toxicological mechanisms.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Chen, Haibo
AU  - Chen H
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, China.
FAU - Wang, Chen
AU  - Wang C
AD  - State Environmental Protection Key Laboratory of Environmental Risk Assessment 
      and Control on Chemical Process, School of Resources and Environmental 
      Engineering, East China University of Science and Technology, Shanghai, 200237, 
      PR China.
FAU - Li, Hui
AU  - Li H
AD  - Institute for Environmental Pollution and Health, School of Environmental and 
      Chemical Engineering, Shanghai University, Shanghai, 200444, PR China. Electronic 
      address: huili@ecust.edu.cn.
FAU - Ma, Ruixue
AU  - Ma R
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, China.
FAU - Yu, Ziling
AU  - Yu Z
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, China.
FAU - Li, Liangzhong
AU  - Li L
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, China.
FAU - Xiang, Mingdeng
AU  - Xiang M
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, China.
FAU - Chen, Xichao
AU  - Chen X
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, China.
FAU - Hua, Xin
AU  - Hua X
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, China; School of Environmental and 
      Municipal Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, China.
FAU - Yu, Yunjiang
AU  - Yu Y
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou, 510655, China. Electronic address: 
      yuyunjiang@scies.org.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190228
PL  - England
TA  - J Environ Manage
JT  - Journal of environmental management
JID - 0401664
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Animals
MH  - Caenorhabditis elegans
MH  - Ecosystem
MH  - *Endocrine Disruptors
MH  - *Environmental Pollutants
MH  - Humans
MH  - *Nematoda
OTO - NOTNLM
OT  - C. elegans
OT  - Different exposures
OT  - EDCs
OT  - POPs
OT  - Toxicity assessments
OT  - Toxicological mechanisms
EDAT- 2019/03/03 06:00
MHDA- 2019/09/26 06:00
CRDT- 2019/03/03 06:00
PHST- 2018/09/27 00:00 [received]
PHST- 2019/02/09 00:00 [revised]
PHST- 2019/02/21 00:00 [accepted]
PHST- 2019/03/03 06:00 [pubmed]
PHST- 2019/09/26 06:00 [medline]
PHST- 2019/03/03 06:00 [entrez]
AID - S0301-4797(19)30262-2 [pii]
AID - 10.1016/j.jenvman.2019.02.102 [doi]
PST - ppublish
SO  - J Environ Manage. 2019 May 1;237:519-525. doi: 10.1016/j.jenvman.2019.02.102. 
      Epub 2019 Feb 28.