PMID- 30826317
OWN - NLM
STAT- MEDLINE
DCOM- 20190617
LR  - 20190617
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 104
DP  - 2019 Jun
TI  - The activity of methacrylate esters in skin sensitisation test methods: A review.
PG  - 14-20
LID - S0273-2300(19)30059-5 [pii]
LID - 10.1016/j.yrtph.2019.02.014 [doi]
AB  - Skin sensitisation associated with allergic contact dermatitis is an important 
      occupational and environmental disease. The identification of skin sensitisation 
      hazards was traditionally performed using animal tests; originally guinea pig 
      assays and subsequently the murine local lymph node assay (LLNA). More recently 
      there has, for a variety of reasons, been an increased interest in, and 
      requirement for, non-animal assays. There are now available both validated in 
      vitro assays and a variety of approaches based on consideration of quantitative 
      structure-activity relationships (QSAR). With the increased availability and use 
      of non-animal alternatives for skin sensitisation testing there is a continuing 
      need to monitor the performance of these approaches using series of chemicals 
      that do not normally form part of validation exercises. Here we report studies 
      conducted with 11 methacrylate esters and methacrylic acid in which results 
      obtained with 3 validated in vitro tests for which there are OECD guidelines (the 
      Direct Peptide Reactivity Assay, DPRA; ARE-Nrf2 luciferase test methods, and - 
      with some chemicals - a dendritic cell activation test, the myeloid U937 Skin 
      Sensitisation test [U-SENS] assay) have been compared with QSAR approaches (DEREK 
      and TIMES-SS), and with LLNA and guinea pig maximisation test (GPMT) data. The 
      conclusions drawn from these data are that - with this series of chemicals at 
      least - there is a strong correlation between the results of animal tests and the 
      in vitro assays considered, but not with either DEREK or TIMES-SS.
CI  - Copyright (c) 2019 The Author. Published by Elsevier Inc. All rights reserved.
FAU - Kimber, Ian
AU  - Kimber I
AD  - Faculty of Biology, Medicine and Health, University of Manchester, Manchester, 
      UK. Electronic address: ian.kimber@manchester.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190228
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Esters)
RN  - 0 (Methacrylates)
RN  - 1CS02G8656 (methacrylic acid)
SB  - IM
MH  - Animals
MH  - Esters/*adverse effects
MH  - Humans
MH  - Methacrylates/*adverse effects
MH  - Skin/*drug effects
MH  - Skin Tests
OTO - NOTNLM
OT  - In vitro assays
OT  - Local lymph node assay
OT  - Methacrylates
OT  - Predictive test methods
OT  - QSAR
OT  - Risk assessment
OT  - Skin sensitisation
EDAT- 2019/03/04 06:00
MHDA- 2019/06/18 06:00
CRDT- 2019/03/04 06:00
PHST- 2019/01/27 00:00 [received]
PHST- 2019/02/19 00:00 [revised]
PHST- 2019/02/22 00:00 [accepted]
PHST- 2019/03/04 06:00 [pubmed]
PHST- 2019/06/18 06:00 [medline]
PHST- 2019/03/04 06:00 [entrez]
AID - S0273-2300(19)30059-5 [pii]
AID - 10.1016/j.yrtph.2019.02.014 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2019 Jun;104:14-20. doi: 10.1016/j.yrtph.2019.02.014. 
      Epub 2019 Feb 28.