PMID- 30826555
OWN - NLM
STAT- MEDLINE
DCOM- 20190417
LR  - 20190417
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 66
DP  - 2019 Mar
TI  - Association of cutaneous adverse drug reactions due to antiepileptic drugs with 
      HLA alleles in a North Indian population.
PG  - 99-103
LID - S1059-1311(18)30723-4 [pii]
LID - 10.1016/j.seizure.2019.02.011 [doi]
AB  - PURPOSE: Aromatic antiepileptic drugs (AEDs) are frequently implicated in 
      cutaneous adverse drug reactions (cADRs), a few of which are associated with 
      certain human leukocyte antigen (HLA) alleles in some populations. We aimed to 
      find HLA-associations with AED-related cADRs among North Indians. METHODS: North 
      Indian subjects with cADR due to an AED, and those who were AED-tolerant were 
      recruited as cases and controls, respectively. Genotyping for HLA-A, B and DRB1 
      were performed. Statistical analysis to compare carrier-rates and 
      allele-frequencies between cases and controls (and healthy population, where 
      necessary), was done for HLA-alleles occurring more than twice in either group. 
      RESULTS: 120 cases 11 - Lamotrigine (LTG), 14 -Valproic acid (VPA), 8 
      -Levetiracetam (LEV), 35 -Carbamazepine (CBZ) and 52 - Phenytoin (PHT), and 250 
      controls were recruited. Presence of HLA-A*31:01 and HLA-B*51:01 were found to 
      increase the risk of Maculopapular exanthema (MPE) due to CBZ and PHT (OR = 6.38; 
      95% CI: 1.46-27.75; OR = 4.60; 95% CI: 1.54-13.72, respectively). Among the 
      severe cADRs, HLA-B*57:01(OR = 11.00 95% CI: 1.41-85.81) and HLA-DRB1*07:01 
      (OR = 7.25; 95% CI: 1.09-48.18) were noted to be significantly associated with 
      CBZ-induced Stevens Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN); 
      HLA-B *51:01 was associated with drug reaction eosinophilia and systemic symptoms 
      (DRESS) caused by PHT (OR = 6.90; 95% CI: 1.38-34.29). CONCLUSIONS: We found 
      significant associations of some HLA alleles with specific cADRs to CBZ and PHT 
      in North Indians, which may need to be tested before AED-initiation; only 
      screening for HLA-B*15:02 may not help in this population.
CI  - Copyright (c) 2019 British Epilepsy Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Ihtisham, Kavish
AU  - Ihtisham K
AD  - All India Institute of Medical Sciences, Neurology, Neurosciences Centre, Room 
      no-705, 7th floor, 110029, New Delhi, India.
FAU - Ramanujam, Bhargavi
AU  - Ramanujam B
AD  - All India Institute of Medical Sciences, Neurology, Neurosciences Centre, Room 
      no-705, 7th floor, 110029, New Delhi, India.
FAU - Srivastava, Shivani
AU  - Srivastava S
AD  - All India Institute of Medical Sciences, Neurology, Neurosciences Centre, Room 
      no-705, 7th floor, 110029, New Delhi, India.
FAU - Mehra, Narinder Kumar
AU  - Mehra NK
AD  - Dr. C.G. Pandit National Chair and Ex-head, Transplant Immunology and 
      Immunogenetics, All India Institute of Medical Sciences, New Delhi, India.
FAU - Kaur, Gurvinder
AU  - Kaur G
AD  - Laboratory Oncology, All India Institute of Medical Sciences, New Delhi, India.
FAU - Khanna, Neena
AU  - Khanna N
AD  - Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Jain, Satish
AU  - Jain S
AD  - Director Indian Epilepsy Centre and President-elect Indian Epilepsy Association.
FAU - Kumar, Sachin
AU  - Kumar S
AD  - Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
FAU - Kaul, Bhavna
AU  - Kaul B
AD  - Neurology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, 
      India.
FAU - Samudrala, Raghavan
AU  - Samudrala R
AD  - Neurology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, 
      India.
FAU - Tripathi, Manjari
AU  - Tripathi M
AD  - All India Institute of Medical Sciences, Neurology, Neurosciences Centre, Room 
      no-705, 7th floor, 110029, New Delhi, India. Electronic address: 
      mtripathiaiims@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20190220
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA Antigens)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RBM45 protein, human)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anticonvulsants/*adverse effects
MH  - Child
MH  - Epilepsy/*drug therapy/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Nerve Tissue Proteins/genetics
MH  - RNA-Binding Proteins/genetics
MH  - Skin Diseases/*chemically induced
MH  - Young Adult
OTO - NOTNLM
OT  - Antiepileptic drugs
OT  - Drug reaction eosinophilia and systemic symptoms (DRESS)
OT  - Human leukocyte antigen (HLA)
OT  - Maculopapular exanthema (MPE)
OT  - Stevens-Johnson syndrome (SJS)
OT  - Toxic Epidermal Necrolysis (TEN)
EDAT- 2019/03/04 06:00
MHDA- 2019/04/18 06:00
CRDT- 2019/03/04 06:00
PHST- 2018/11/14 00:00 [received]
PHST- 2019/02/14 00:00 [revised]
PHST- 2019/02/16 00:00 [accepted]
PHST- 2019/03/04 06:00 [pubmed]
PHST- 2019/04/18 06:00 [medline]
PHST- 2019/03/04 06:00 [entrez]
AID - S1059-1311(18)30723-4 [pii]
AID - 10.1016/j.seizure.2019.02.011 [doi]
PST - ppublish
SO  - Seizure. 2019 Mar;66:99-103. doi: 10.1016/j.seizure.2019.02.011. Epub 2019 Feb 
      20.