PMID- 30826905
OWN - NLM
STAT- MEDLINE
DCOM- 20200427
LR  - 20210412
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Linking)
VI  - 58
IP  - 8
DP  - 2019 Dec
TI  - The novel insight into anti-inflammatory and anxiolytic effects of psychobiotics 
      in diabetic rats: possible link between gut microbiota and brain regions.
PG  - 3361-3375
LID - 10.1007/s00394-019-01924-7 [doi]
AB  - PURPOSE: Type 2 diabetes mellitus (T2DM) was associated with gut microbial 
      impairment (dysbiosis) and neurological and behavioral disorders. The role of the 
      gut-brain axis in the management of many diseases including T2DM has been the 
      focus of much research activity in the recent years. However, a wide knowledge 
      gap exists about the gut microbial effects on the function of glia cells. Hence, 
      the present study was aimed to examine the effects of psychobatics on dysbiosis 
      and glia cells function in enteric and central nervous system with an 
      inflammatory insight in T2DM. METHODS: Thirty rats were treated by Lactobacillus 
      (L.) plantarum, inulin, or their combination (synbiotic) for 8 weeks after 
      inducing T2DM. Fecal sample was collected to evaluate gut microbial composition. 
      Then, the rats were sacrificed, and the colon, amygdala, and prefrontal cortex 
      (PFC) were studied. RESULTS: T2DM resulted in dysbiosis and increased levels of 
      glial cell-derived neurotrophic factor (GDNF), glial fibrillary acidic protein 
      (GFAP), and inflammatory markers (IL-17, IL-6, and TLR-2) in the colon and brain. 
      However, concurrent supplementation of L. plantarum and inulin could improve the 
      gut microbial composition as well as reduce the levels of inflammatory cytokines. 
      While the administration of L. plantarum led to a significant decrease in TLR-2 
      as well as GDNF and GFAP only in the amygdala, the synbiotic intake could make 
      such changes in the colon, amygdala, and PFC. CONCLUSIONS: Our findings 
      demonstrated an innovative approach to the beneficial effects of psychobiotics in 
      neuroinflammation and behavioral performance through gut microbiota changes, 
      focusing on possible role of glial cells in gut-brain axis.
FAU - Hosseinifard, Elaheh-Sadat
AU  - Hosseinifard ES
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Morshedi, Mohammad
AU  - Morshedi M
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Bavafa-Valenlia, Khadijeh
AU  - Bavafa-Valenlia K
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Saghafi-Asl, Maryam
AU  - Saghafi-Asl M
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. saghafiaslm@gmail.com.
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran. saghafiaslm@gmail.com.
AD  - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran. saghafiaslm@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20190302
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 9005-80-5 (Inulin)
SB  - IM
EIN - Eur J Nutr. 2019 Sep 6;:. PMID: 31492974
MH  - Animals
MH  - Anti-Anxiety Agents/administration & dosage/*pharmacology
MH  - Anti-Inflammatory Agents/administration & dosage/*pharmacology
MH  - Brain/*drug effects/microbiology
MH  - Diabetes Mellitus, Experimental/*microbiology/physiopathology
MH  - Disease Models, Animal
MH  - Dysbiosis/drug therapy/microbiology/physiopathology
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Inulin/administration & dosage/*pharmacology
MH  - *Lactobacillus plantarum
MH  - Male
MH  - Neuroglia/drug effects/microbiology
MH  - Rats
MH  - Rats, Wistar
MH  - Synbiotics/*administration & dosage
OTO - NOTNLM
OT  - Anxiety-like behaviors
OT  - Glial cell-derived neurotrophic factor
OT  - Glial fibrillary acidic protein
OT  - Gut-brain axis
OT  - Inflammation
OT  - Psychobiotic
EDAT- 2019/03/04 06:00
MHDA- 2020/04/28 06:00
CRDT- 2019/03/04 06:00
PHST- 2018/09/30 00:00 [received]
PHST- 2019/02/05 00:00 [accepted]
PHST- 2019/03/04 06:00 [pubmed]
PHST- 2020/04/28 06:00 [medline]
PHST- 2019/03/04 06:00 [entrez]
AID - 10.1007/s00394-019-01924-7 [pii]
AID - 10.1007/s00394-019-01924-7 [doi]
PST - ppublish
SO  - Eur J Nutr. 2019 Dec;58(8):3361-3375. doi: 10.1007/s00394-019-01924-7. Epub 2019 
      Mar 2.