PMID- 30827311
OWN - NLM
STAT- MEDLINE
DCOM- 20190725
LR  - 20190725
IS  - 2095-4352 (Print)
VI  - 31
IP  - 2
DP  - 2019 Feb
TI  - [Clinical observation on application of different enteral nutrition preparations 
      in patients with severe traumatic brain injury].
PG  - 209-213
LID - 10.3760/cma.j.issn.2095-4352.2019.02.017 [doi]
AB  - OBJECTIVE: To observe the effects of enteral nutrition (EN) emulsion with 
      different components on nutritional index, blood glucose, inflammatory reaction, 
      gastrointestinal tolerance and prognosis in patients with severe traumatic brain 
      injury (sTBI). METHODS: Patients with sTBI [Glasgow coma scale (GCS) < 8] 
      admitted to intensive care unit (ICU) of Affiliated Hospital of Guizhou Medical 
      University from January 2016 to May 2018 were retrospectively analyzed. These 
      patients had received EN, 30 cases of them were fed with Baipuli, 35 cases were 
      fed with Ruineng, and 30 cases were fed with Ruisu. The EN support began within 
      48 hours after the patients were transferred to ICU, and the energy intake of 
      83.68-104.60 kJxkg(-1)xd(-1) was the nutritional support target. The hemoglobin 
      (Hb), lymphocyte count (LYM), serum albumin (Alb), pre-albumin (PA), 
      procalcitonin (PCT), average blood glucose (GLUave) and blood glucose variation 
      coefficient (GLUcv) were observed 7 days after EN support, EN compliance time, 
      gastrointestinal tolerance situations were recorded, and the duration of 
      mechanical ventilation (MV), the length of ICU stay and incidence of nosocomial 
      infection were compared among the three groups. RESULTS: There were no obvious 
      changes in Hb, LYM, Alb, PCT among three groups after treatment on the 7th day, 
      and there was no significant difference among the three groups. The PA of Baipuli 
      group was significantly higher than that in Ruineng and Ruisu groups at 7 days 
      after treatment (mg/L: 275.55+/-46.18 vs. 238.25+/-49.59, 240.70+/-55.59, both P < 
      0.05), but the GLUave and GLUcv were much higher than those in Ruineng and Ruisu 
      groups [GLUave (mmol/L): 10.02+/-2.39 vs. 8.53+/-1.53, 8.98+/-1.75; GLUcv: 
      (23.59+/-3.93)% vs. (14.79+/-3.65)%, (17.88+/-2.90)%, all P < 0.05]. The indexes of 
      gastrointestinal tolerance in Baipuli group were better than those of Ruineng and 
      Ruisu groups: the target feeding time was reached ahead (days: 4.40+/-1.20 vs. 
      5.50+/-1.07, 5.45+/-1.02, both P < 0.05), the incidence of gastric retention and 
      digestive tract hemorrhage were both decreased [6.67% (2/30) vs. 31.43% (11/35), 
      33.33% (10/30); 3.33% (1/30) vs. 14.29% (5/35), 16.67% (5/30), all P < 0.05]. The 
      duration of MV and the length of ICU stay in Ruisu and Baipuli groups were longer 
      than those of Ruineng group [duration of MV (days): 6.94+/-1.64, 6.79+/-1.14 vs. 
      5.93+/-1.12; the length of ICU stay (days): 9.40+/-2.18, 10.40+/-2.35 vs. 7.45+/-1.83, 
      all P < 0.05]. There was no significant difference in the incidences of 
      nosocomial infection among Ruineng, Ruisu, and Baipuli groups [the incidence of 
      ventilator-associated pneumonia (VAP): 11.43%, 10.00%, 10.00%; catheter related 
      bloodstream infection: 0, 0, 3.33%; urinary tract infection: 5.71%, 6.67%, 6.67%; 
      intracranial infection: 2.86%, 6.67%, 3.33%, all P > 0.05]. CONCLUSIONS: For 
      patients with sTBI, short peptide EN preparations (Baipuli) is much better in 
      gastrointestinal tolerance but it can cause fluctuations of blood glucose; the 
      whole protein EN containing omega-3 fatty acid (Ruineng, Ruisu) has relatively less 
      fluctuation on blood glucose, the duration of MV and the length of ICU stay can 
      be shortened by Ruineng, therefore it is more suitable to be applied for such 
      patients.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Critical Care Medicine, the Affiliated Hospital of Guizhou Medical 
      University, Guiyang 550004, Guizhou, China. Corresponding author: Wang Difen, 
      Email: 1078666485@qq.com.
FAU - Wang, Difen
AU  - Wang D
FAU - Fu, Jiangquan
AU  - Fu J
FAU - Liu, Xu
AU  - Liu X
FAU - Liu, Ying
AU  - Liu Y
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhonghua wei zhong bing ji jiu yi xue
JID - 101604552
MH  - Brain Injuries, Traumatic/*therapy
MH  - Enteral Nutrition/*methods
MH  - Humans
MH  - Intensive Care Units
MH  - Respiration, Artificial
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2019/03/05 06:00
MHDA- 2019/07/26 06:00
CRDT- 2019/03/05 06:00
PHST- 2019/03/05 06:00 [entrez]
PHST- 2019/03/05 06:00 [pubmed]
PHST- 2019/07/26 06:00 [medline]
AID - 10.3760/cma.j.issn.2095-4352.2019.02.017 [doi]
PST - ppublish
SO  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Feb;31(2):209-213. doi: 
      10.3760/cma.j.issn.2095-4352.2019.02.017.