PMID- 30827823
OWN - NLM
STAT- MEDLINE
DCOM- 20201117
LR  - 20201117
IS  - 2212-2672 (Print)
IS  - 2212-2672 (Linking)
VI  - 120
IP  - 4
DP  - 2020 Apr
TI  - The Effects of Prebiotics and Substances with Prebiotic Properties on Metabolic 
      and Inflammatory Biomarkers in Individuals with Type 2 Diabetes Mellitus: A 
      Systematic Review.
PG  - 587-607.e2
LID - S2212-2672(18)31341-8 [pii]
LID - 10.1016/j.jand.2018.12.013 [doi]
AB  - BACKGROUND: Intestinal bacteria composition and prebiotics may play a role in the 
      management of type 2 diabetes mellitus (T2DM). OBJECTIVE: The objective of this 
      systematic review was to evaluate the effect of prebiotics and substances with 
      prebiotic properties on the metabolic and inflammatory biomarkers of individuals 
      with T2DM compared with placebo. METHODS: A literature search to identify 
      articles published up to March 31, 2018, was conducted utilizing PubMed, Science 
      Direct, and Cochrane Central Register of Controlled Trials. Individuals at aged 
      18 years or older with T2DM from randomized controlled trials investigating 
      prebiotics or substances with prebiotic properties were included. Metabolic and 
      inflammatory biomarkers associated with T2DM were the primary outcome measures. 
      RESULTS: Twenty-seven publications were analyzed. All but seven of these 
      publications reported a beneficial effect on metabolic and/or inflammatory 
      biomarkers. Interventions included mostly women, lasted 4 days to 12 weeks, and 
      diabetes duration ranged from 6 months to 11 years. Nineteen publications 
      reported improvements in glycemia, 15 in cardiovascular markers, nine in body 
      weight, and nine in inflammatory markers. Benefits from resistant starch, 
      resistant dextrin, and oligofructose-enriched inulin were most frequent. A 
      smaller number of studies utilizing other substances with prebiotic properties 
      also yielded improvements. CONCLUSIONS: Based on these results, there is fair 
      evidence that prebiotics and substances with prebiotic properties may improve 
      metabolic and inflammatory biomarkers related to T2DM in women aged 18 years at 
      least. Interventions with resistant starch, resistant dextrin, and 
      oligofructose-enriched inulin exhibited the strongest evidence for improvements 
      due to the quantity of publications and quality grades. Other prebiotics and 
      substances with prebiotic properties show promise but the number of studies is 
      few. Additional studies that are longer in duration, include both sexes, and 
      include other prebiotics or substances with prebiotic properties are needed.
CI  - Copyright (c) 2020 Academy of Nutrition and Dietetics. Published by Elsevier Inc. 
      All rights reserved.
FAU - Colantonio, Angela G
AU  - Colantonio AG
FAU - Werner, Sharon L
AU  - Werner SL
FAU - Brown, Melissa
AU  - Brown M
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20190228
PL  - United States
TA  - J Acad Nutr Diet
JT  - Journal of the Academy of Nutrition and Dietetics
JID - 101573920
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Prebiotics)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*blood/*microbiology
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - Middle Aged
MH  - Prebiotics/*administration & dosage
OTO - NOTNLM
OT  - Fiber
OT  - Inulin
OT  - Prebiotics
OT  - Resistant starch/dextrin
OT  - Type 2 diabetes mellitus
EDAT- 2019/03/05 06:00
MHDA- 2020/11/18 06:00
CRDT- 2019/03/05 06:00
PHST- 2018/07/12 00:00 [received]
PHST- 2018/12/19 00:00 [revised]
PHST- 2018/12/20 00:00 [accepted]
PHST- 2019/03/05 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2019/03/05 06:00 [entrez]
AID - S2212-2672(18)31341-8 [pii]
AID - 10.1016/j.jand.2018.12.013 [doi]
PST - ppublish
SO  - J Acad Nutr Diet. 2020 Apr;120(4):587-607.e2. doi: 10.1016/j.jand.2018.12.013. 
      Epub 2019 Feb 28.