PMID- 3082824
OWN - NLM
STAT- MEDLINE
DCOM- 19860519
LR  - 20141120
IS  - 0910-5050 (Print)
IS  - 0910-5050 (Linking)
VI  - 77
IP  - 2
DP  - 1986 Feb
TI  - Augmentation of ethanol-induced enhancement of dimethylnitrosamine and 
      diethylnitrosamine metabolism by lowered carbohydrate intake.
PG  - 125-30
AB  - Hepatic metabolism in vitro of dimethylnitrosamine (DMN), diethylnitrosamine 
      (DEN), 3,4-benzopyrene (BP) and 7,12-dimethylbenz[a]anthracene (DMBA) was assayed 
      using the liver of rats maintained for 3 weeks on liquid diets containing three 
      levels of carbohydrate (CHO) with or without supplementation of ethanol (5 g/100 
      ml). Ethanol consumption increased the metabolism of DMN and DEN to different 
      degrees depending on the diet consumed simultaneously. Lowered CHO intake, which 
      by itself increased the metabolism, dose-dependently augmented the increase due 
      to ethanol: the lower the CHO intake, the more remarkable was the enhancement 
      caused by ethanol. Ethanol increased microsomal cytochrome P-450 content only 
      when combined with low-CHO diets. It was confirmed by a Salmonella mutagenicity 
      test that the enhancement of DMN and DEN metabolism was accompanied by increased 
      capacity of the liver to activate these nitrosamines to mutagens. On the other 
      hand, neither lowered CHO intake, nor ethanol consumption, nor their combination 
      affected the metabolism of BP and DMBA. Ethanol combined with a diet deficient in 
      CHO even suppressed the metabolism of BP.
FAU - Sato, A
AU  - Sato A
FAU - Yonekura, I
AU  - Yonekura I
FAU - Asakawa, M
AU  - Asakawa M
FAU - Nakahara, H
AU  - Nakahara H
FAU - Nakajima, T
AU  - Nakajima T
FAU - Ohta, S
AU  - Ohta S
FAU - Shirai, T
AU  - Shirai T
FAU - Ito, N
AU  - Ito N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Proteins)
RN  - 3417WMA06D (Benzo(a)pyrene)
RN  - 3IQ78TTX1A (Diethylnitrosamine)
RN  - 3K9958V90M (Ethanol)
RN  - 57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - M43H21IO8R (Dimethylnitrosamine)
SB  - IM
MH  - 9,10-Dimethyl-1,2-benzanthracene/metabolism
MH  - Animals
MH  - Benzo(a)pyrene/metabolism
MH  - Cytochrome P-450 Enzyme System/analysis
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Diethylnitrosamine/*metabolism
MH  - Dimethylnitrosamine/*metabolism
MH  - Ethanol/*pharmacology
MH  - In Vitro Techniques
MH  - Kinetics
MH  - Liver/*metabolism
MH  - Male
MH  - Mutagenicity Tests
MH  - Proteins/analysis
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1986/02/01 00:00
MHDA- 1986/02/01 00:01
CRDT- 1986/02/01 00:00
PHST- 1986/02/01 00:00 [pubmed]
PHST- 1986/02/01 00:01 [medline]
PHST- 1986/02/01 00:00 [entrez]
PST - ppublish
SO  - Jpn J Cancer Res. 1986 Feb;77(2):125-30.