PMID- 30828244
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1176-9343 (Print)
IS  - 1176-9343 (Electronic)
IS  - 1176-9343 (Linking)
VI  - 15
DP  - 2019
TI  - Dual Analysis of Virus-Host Interactions: The Case of Ostreid herpesvirus 1 and 
      the Cupped Oyster Crassostrea gigas.
PG  - 1176934319831305
LID - 10.1177/1176934319831305 [doi]
LID - 1176934319831305
AB  - Dual analyses of the interactions between Ostreid herpesvirus 1 (OsHV-1) and the 
      bivalve Crassostrea gigas during infection can unveil events critical to the 
      onset and progression of this viral disease and can provide novel strategies for 
      mitigating and preventing oyster mortality. Among the currently used "omics" 
      technologies, dual transcriptomics (dual RNA-seq) coupled with the analysis of 
      viral DNA in the host tissues has greatly advanced the knowledge of genes and 
      pathways mostly contributing to host defense responses, expression profiles of 
      annotated and unknown OsHV-1 open reading frames (ORFs), and viral genome 
      variability. In addition to dual RNA-seq, proteomics and metabolomics analyses 
      have the potential to add complementary information, needed to understand how a 
      malacoherpesvirus can redirect and exploit the vital processes of its host. This 
      review explores our current knowledge of "omics" technologies in the study of 
      host-pathogen interactions and highlights relevant applications of these fields 
      of expertise to the complex case of C gigas infections by OsHV-1, which currently 
      threaten the mollusk production sector worldwide.
FAU - Rosani, Umberto
AU  - Rosani U
AUID- ORCID: 0000-0003-0685-1618
AD  - Department of Biology, University of Padova, Padova, Italy.
FAU - Young, Tim
AU  - Young T
AD  - Aquaculture Biotechnology Research Group, School of Science, Faculty of Health 
      and Environmental Sciences, Auckland University of Technology, Auckland, New 
      Zealand.
FAU - Bai, Chang-Ming
AU  - Bai CM
AD  - Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture, 
      Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, 
      Qingdao, China.
FAU - Alfaro, Andrea C
AU  - Alfaro AC
AD  - Aquaculture Biotechnology Research Group, School of Science, Faculty of Health 
      and Environmental Sciences, Auckland University of Technology, Auckland, New 
      Zealand.
FAU - Venier, Paola
AU  - Venier P
AUID- ORCID: 0000-0001-9634-3662
AD  - Department of Biology, University of Padova, Padova, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190222
PL  - United States
TA  - Evol Bioinform Online
JT  - Evolutionary bioinformatics online
JID - 101256319
PMC - PMC6388457
OTO - NOTNLM
OT  - Crassostrea gigas
OT  - OsHV-1
OT  - omics
COIS- Declaration of conflicting interests:The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2019/03/05 06:00
MHDA- 2019/03/05 06:01
PMCR- 2019/02/22
CRDT- 2019/03/05 06:00
PHST- 2018/11/22 00:00 [received]
PHST- 2019/01/14 00:00 [accepted]
PHST- 2019/03/05 06:00 [entrez]
PHST- 2019/03/05 06:00 [pubmed]
PHST- 2019/03/05 06:01 [medline]
PHST- 2019/02/22 00:00 [pmc-release]
AID - 10.1177_1176934319831305 [pii]
AID - 10.1177/1176934319831305 [doi]
PST - epublish
SO  - Evol Bioinform Online. 2019 Feb 22;15:1176934319831305. doi: 
      10.1177/1176934319831305. eCollection 2019.