PMID- 30829087
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20190903
IS  - 1091-7691 (Electronic)
IS  - 0895-8378 (Linking)
VI  - 30
IP  - 13-14
DP  - 2018 Nov-Dec
TI  - Repeated dose inhalation developmental toxicity study in rats exposed to 
      cellulose insulation with boric acid additive.
PG  - 542-552
LID - 10.1080/08958378.2019.1576806 [doi]
AB  - Cellulose insulation (CI), a common building material, is a mixture of cellulose 
      fibers and borates. Borates are approximately 20% of the product weight and act 
      as a flame retardant. Given possible exposure to workers and consumers, an 
      inhalation toxicity study was conducted following Organization for Economic 
      Co-operation and Development (OECD) 414 for Prenatal Development Toxicity to 
      evaluate if CI is a developmental toxicant. Pregnant female rats were exposed by 
      nose-only inhalation to CI aerosols containing 20% boric acid for six h/day, from 
      gestational day (GD) 6-19, and fetuses were evaluated for developmental 
      parameters. Respirable CI was produced by grinding to produce respirable 
      particles (MMAD 2.7-2.9 microm, geometric standard deviations (GSD) 1.9-2.6), which 
      were then aerosolized. Target air concentrations were 15, 90, and 270 mg CI/m(3). 
      Controls were exposed to air only. Slight body weight reductions (average 
      decrease <7% vs. control) were observed in male and female GD 20 fetuses in the 
      mid and high dose groups. No embryo/fetal developmental toxicity or alterations 
      in any other measured variable were reported at any dose. The no observed adverse 
      effect level (NOAEL) for developmental outcomes was 270 mg/m(3).
FAU - Pleus, Richard C
AU  - Pleus RC
AD  - a Intertox , Seattle , WA , USA.
FAU - Bruce, Gretchen
AU  - Bruce G
AD  - a Intertox , Seattle , WA , USA.
FAU - Klintworth, Heather
AU  - Klintworth H
AD  - a Intertox , Seattle , WA , USA.
FAU - Sullivan, Dennis
AU  - Sullivan D
AD  - b IIT Research Institute , Chicago , IL , USA.
FAU - Johnson, William
AU  - Johnson W
AD  - b IIT Research Institute , Chicago , IL , USA.
FAU - Rajendran, Narayanan
AU  - Rajendran N
AD  - b IIT Research Institute , Chicago , IL , USA.
FAU - Keenan, James
AU  - Keenan J
AD  - c Exponent , Alexandria , VA , USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190304
PL  - England
TA  - Inhal Toxicol
JT  - Inhalation toxicology
JID - 8910739
RN  - 0 (Boric Acids)
RN  - 9004-34-6 (Cellulose)
RN  - R57ZHV85D4 (boric acid)
SB  - IM
MH  - Administration, Inhalation
MH  - Animals
MH  - Boric Acids/*toxicity
MH  - Cellulose/*toxicity
MH  - Construction Materials/*toxicity
MH  - Female
MH  - Fetus/drug effects
MH  - Male
MH  - Maternal-Fetal Exchange
MH  - No-Observed-Adverse-Effect Level
MH  - Pregnancy
MH  - Rats, Sprague-Dawley
MH  - Toxicity Tests
OTO - NOTNLM
OT  - Boric acid
OT  - cellulose insulation
OT  - developmental toxicity
OT  - particulates
OT  - rats
OT  - respiratory toxicity
EDAT- 2019/03/05 06:00
MHDA- 2019/09/04 06:00
CRDT- 2019/03/05 06:00
PHST- 2019/03/05 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2019/03/05 06:00 [entrez]
AID - 10.1080/08958378.2019.1576806 [doi]
PST - ppublish
SO  - Inhal Toxicol. 2018 Nov-Dec;30(13-14):542-552. doi: 
      10.1080/08958378.2019.1576806. Epub 2019 Mar 4.