PMID- 30831612
OWN - NLM
STAT- MEDLINE
DCOM- 20190411
LR  - 20190411
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 99
IP  - 9
DP  - 2019 Mar 5
TI  - [Effect of non-breathing-related sleep fragmentation on cognitive function in 
      patients with cerebral small vessel disease].
PG  - 653-657
LID - 10.3760/cma.j.issn.0376-2491.2019.09.004 [doi]
AB  - Objective: To investigate the effect of non-breathing-related sleep fragmentation 
      on cognitive function in patients with atherosclerotic cerebral small vessel 
      disease(CSVD). Methods: Seventy-two patients with arteriosclerotic CSVD in the 
      Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University 
      were enrolled in this study from August 2017 to July 2018. The patients undertook 
      MRA(Magnetic Resonance Angiography)+SWI(Susceptibility weighted imaging), 
      polysomnography, Montreal Cognitive Inventory (MoCA) and Concise Mental State 
      Examination (MMSE). The patients were divided into study group (>/=19) and control 
      group (<19) according to the median number of arousal events (median=19) at 
      night. Results: The sleep efficiency, rapid eye movement (REM) sleep ratio and 
      non-rapid eye movement-3 (NREM-3) sleep ratio of the study group were 
      significantly lower than those of the control group (P<0.05), and the total MoCA 
      score (18.2+/-4.3) , visual space score(1.9+/-1.4) and delayed recall score(1.4+/-0.9) 
      of the study group were significantly lower than those of the control group 
      (22.7+/-3.5, 2.9+/-1.2, 2.9+/-1.1, P<0.05). Conclusion: The incidence of 
      non-breathing-related sleep fragmentation is high in CSVD patients and this kind 
      of fragmentation is associated with cognitive impairment.
FAU - Wang, J H
AU  - Wang JH
AD  - Department of Psychiatry, the Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510630, China.
FAU - Chen, X D
AU  - Chen XD
AD  - Department of Neurology, the Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510630, China.
FAU - Liao, J C
AU  - Liao JC
AD  - Department of Neurology, the Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510630, China.
FAU - Liao, S Y
AU  - Liao SY
AD  - Department of Neurology, the Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510630, China.
FAU - Liu, S X
AU  - Liu SX
AD  - Department of Neurology, the Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510630, China.
FAU - Lu, Z Z
AU  - Lu ZZ
AD  - Department of Neurology, the Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510630, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - *Cerebral Small Vessel Diseases/complications
MH  - Cognition
MH  - *Cognition Disorders/etiology
MH  - Humans
MH  - Polysomnography
MH  - *Sleep Deprivation/etiology
OTO - NOTNLM
OT  - Arousal
OT  - Cerebrovascular disorders
OT  - Cognitive disorders
OT  - Polysomnography
OT  - Sleep
EDAT- 2019/03/05 06:00
MHDA- 2019/04/12 06:00
CRDT- 2019/03/05 06:00
PHST- 2019/03/05 06:00 [entrez]
PHST- 2019/03/05 06:00 [pubmed]
PHST- 2019/04/12 06:00 [medline]
AID - 10.3760/cma.j.issn.0376-2491.2019.09.004 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2019 Mar 5;99(9):653-657. doi: 
      10.3760/cma.j.issn.0376-2491.2019.09.004.