PMID- 30831648
OWN - NLM
STAT- MEDLINE
DCOM- 20190404
LR  - 20190404
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 48
IP  - 3
DP  - 2019 Mar 8
TI  - [Clinicopathological features and prognosis of ALK-positive Spitz tumors].
PG  - 215-219
LID - 10.3760/cma.j.issn.0529-5807.2019.03.009 [doi]
AB  - Objective: To investigate the clinicopathologic features and prognosis of 
      ALK-positive Spitz tumors. Methods: Thirteen patients with ALK-positive Spitz 
      tumors diagnosed at Shanghai Cancer Center, Fudan University from October 2016 to 
      December 2017 were collected. All cases were routinely evaluated 
      histopathological features in HE staining and detected ALK protein expression by 
      immunohistochemistry. The ALK fusions of 7 cases were confirmed by fluorescence 
      in situ hybridization (FISH).Follow-up data was collected. Results: The age of 
      patients including 2 males and 11 females ranged from 4 to 47 years (mean 25 
      years). 12 patients were diagnosed with atypical Spitz tumors and 1 patient was 
      diagnosed with Spitz nevus. Clinically, most lesions presented as papules or 
      nodules, while a few lesions presented as plaques. Histologically, most tumors 
      were exophytic (9/13). More than half of the tumors were amelanotic and the 
      junctional component was mainly composed of melanocytic nests. Kamino bodies were 
      not found. The bases of the tumors were mainly wedge-shaped (5/13) and flat 
      (7/13). Eight tumors displayed mixed cell types, while 5 tumors were composed of 
      only spindle cells. All the tumors showed a plexiform and/or intersecting 
      fascicular growth pattern, and perineural extension was observed in 3 tumors. ALK 
      immunohistochemistry showed diffuse and intense cytoplasmic staining in 13 cases, 
      and 7 of them were detected by FISH to confirm the presence of ALK fusions. All 
      patients were followed up for 7 to 21 months (median=12), with no recurrence or 
      lymph node dissemination. Conclusions: Spitz tumors with ALK fusions have their 
      special histopathologic features.ALK fusions mainly occur in Spitz nevi and 
      atypical Spitz tumors. The follow-up data of the existing literatures and our 
      research indicates that the prognosis of ALK-positive Spitz tumors may be good.
FAU - Ren, J
AU  - Ren J
AD  - Department of Pathology, Shanghai Cancer Center, Fudan University and Department 
      of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Ren, M
AU  - Ren M
AD  - Department of Pathology, Shanghai Cancer Center, Fudan University and Department 
      of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Kong, Y Y
AU  - Kong YY
AD  - Department of Pathology, Shanghai Cancer Center, Fudan University and Department 
      of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Cai, X
AU  - Cai X
AD  - Department of Pathology, Shanghai Cancer Center, Fudan University and Department 
      of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Kong, J C
AU  - Kong JC
AD  - Clinical Pathological Diagnosis Center of Fudan University, Shanghai 200032, 
      China.
LA  - chi
GR  - 16411967800/Science and Technology Commission of Shanghai Municipality/
GR  - 2015ZB0204/Shanghai Municipal Commission of Health and Family Planning/
GR  - SHDC12014105/Shanghai Hospital Development Center Emerging Advanced Technology 
      Joint Research Project/
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Neoplasm Proteins)
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anaplastic Lymphoma Kinase/*analysis
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*analysis
MH  - Nevus, Epithelioid and Spindle Cell/*chemistry/mortality/*pathology
MH  - Prognosis
MH  - Skin Neoplasms/*chemistry/mortality/*pathology
MH  - Young Adult
OTO - NOTNLM
OT  - Immunohistochemistry
OT  - In situ hybridization, fluorescence
OT  - Prognosis
OT  - Skin neoplasms
EDAT- 2019/03/05 06:00
MHDA- 2019/04/05 06:00
CRDT- 2019/03/05 06:00
PHST- 2019/03/05 06:00 [entrez]
PHST- 2019/03/05 06:00 [pubmed]
PHST- 2019/04/05 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2019.03.009 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2019 Mar 8;48(3):215-219. doi: 
      10.3760/cma.j.issn.0529-5807.2019.03.009.