PMID- 30834396
OWN - NLM
STAT- MEDLINE
DCOM- 20190808
LR  - 20190808
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 144
IP  - 8
DP  - 2019 Apr 8
TI  - A highly sensitive and versatile chiral sensor based on a top-gate organic field 
      effect transistor functionalized with thiolated beta-cyclodextrin.
PG  - 2611-2617
LID - 10.1039/c8an02339e [doi]
AB  - The discrimination of chirality by field effect transistors (FETs) is a great 
      challenge because enantiomers possess exactly identical charge and hence chiral 
      recognition is solely related to spatial effects, while the working principle of 
      most FET sensors is based on the intrinsic charge of analytes. In this work, a 
      chiral organic field effect transistor (COFET) with a self-assembled thiolated 
      beta-cyclodextrin (SH-beta-CD) monolayer modified gold top-gate electrode is developed 
      to afford rapid, highly sensitive and real-time chiral discrimination for various 
      enantiomers. Well-defined sensing results are achieved for diverse acidic 
      enantiomers with the lowest detection concentration (LDC) of 10-12 M. Chiral 
      sensing mostly depends on the changed work function of the top electrode and 
      hence varied surface potential at the gate/solution interface caused by the 
      target-induced CD-enantiomer complex formation with different geometries for each 
      isomer, which is independent of the intrinsic charge of the analytes. This 
      proof-of-concept allows chiral resolution even for uncharged enantiomers, which 
      still remains as a major hurdle for FET-based sensors. Furthermore, the COFET 
      shows composition dependence for its response towards the enantiomer mixture of 
      phenylalanine (Phe) and a "real world" pharmaceutical drug (ibuprofen), which 
      proves the potentiality of the COFET for quantitative chiral analysis of 
      commercial pharmaceutical drugs.
FAU - Wang, Xuepeng
AU  - Wang X
AD  - School of Chemical Engineering and Technology, Tianjin Engineering Research 
      Center of Functional Fine Chemicals, Tianjin University, Tianjin 300072, China. 
      xiaoyin@tju.edu.cn.
FAU - Wang, Yong
AU  - Wang Y
FAU - Wu, Yifan
AU  - Wu Y
FAU - Xiao, Yin
AU  - Xiao Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (beta-Cyclodextrins)
RN  - 7440-57-5 (Gold)
RN  - WK2XYI10QM (Ibuprofen)
MH  - Electrochemical Techniques/instrumentation/*methods
MH  - Electrodes
MH  - Gold/chemistry
MH  - Ibuprofen/*analysis/chemistry
MH  - Stereoisomerism
MH  - *Transistors, Electronic
MH  - beta-Cyclodextrins/*chemistry
EDAT- 2019/03/06 06:00
MHDA- 2019/08/09 06:00
CRDT- 2019/03/06 06:00
PHST- 2019/03/06 06:00 [pubmed]
PHST- 2019/08/09 06:00 [medline]
PHST- 2019/03/06 06:00 [entrez]
AID - 10.1039/c8an02339e [doi]
PST - ppublish
SO  - Analyst. 2019 Apr 8;144(8):2611-2617. doi: 10.1039/c8an02339e.