PMID- 30835274
OWN - NLM
STAT- MEDLINE
DCOM- 20200520
LR  - 20200520
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 104
IP  - 8
DP  - 2019 Aug 1
TI  - High-Density Lipoprotein Function Is Reduced in Patients Affected by Genetic or 
      Idiopathic Hypogonadism.
PG  - 3097-3107
LID - 10.1210/jc.2018-02027 [doi]
AB  - CONTEXT: Low testosterone levels are associated with an increased incidence of 
      cardiovascular (CV) events, but the underlying biochemical mechanisms are not 
      fully understood. The clinical condition of hypogonadism offers a unique model to 
      unravel the possible role of lipoprotein-associated abnormalities in CV risk. In 
      particular, the assessment of the functional capacities of high-density 
      lipoproteins (HDLs) may provide insights besides traditional risk factors. 
      DESIGN: To determine whether reduced testosterone levels correlate with 
      lipoprotein function, HDL cholesterol (HDL-C) efflux capacity (CEC) and serum 
      cholesterol loading capacity (CLC). PARTICIPANTS: Genetic and idiopathic 
      hypogonadal patients (n = 20) and control subjects (n = 17). RESULTS: Primary and 
      secondary hypogonadal patients presented with lower HDL ATP-binding cassette 
      transporter A1 (ABCA1)-, ATP-binding cassette transporter G1 (ABCG1)-, and 
      aqueous diffusion-mediated CEC (-19.6%, -40.9%, and -12.9%, respectively), with a 
      16.2% decrement of total CEC. In the whole series, positive correlations between 
      testosterone levels and both total HDL CEC (r2 = 0.359, P = 0.0001) and ABCG1 HDL 
      CEC (r2 = 0.367, P = 0.0001) were observed. Conversely, serum CLC was markedly 
      raised (+43%) in hypogonadals, increased, to a higher extent, in primary vs 
      secondary hypogonadism (18.45 +/- 2.78 vs 15.15 +/- 2.10 microg cholesterol/mg protein) 
      and inversely correlated with testosterone levels (r2 = 0.270, P = 0.001). HDL-C 
      concentrations did not correlate with either testosterone levels, HDL CEC (total, 
      ABCG1, and ABCA1) or serum CLC. CONCLUSIONS: In hypogonadal patients, 
      proatherogenic lipoprotein-associated changes are associated with lower 
      cholesterol efflux and increased influx, thus offering an explanation for a 
      potentially increased CV risk.
CI  - Copyright (c) 2019 Endocrine Society.
FAU - Adorni, Maria Pia
AU  - Adorni MP
AD  - Department of Food and Drug, University of Parma, Parma, Italy.
FAU - Zimetti, Francesca
AU  - Zimetti F
AD  - Department of Food and Drug, University of Parma, Parma, Italy.
FAU - Cangiano, Biagio
AU  - Cangiano B
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Milan, Italy.
AD  - Laboratory of Endocrine and Metabolic Research and Division of Endocrine and 
      Metabolic Diseases, Istituto di Ricovero e Cura a Carattere Scientifico Istituto 
      Auxologico Italiano, Milan, Italy.
FAU - Vezzoli, Valeria
AU  - Vezzoli V
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Milan, Italy.
AD  - Laboratory of Endocrine and Metabolic Research and Division of Endocrine and 
      Metabolic Diseases, Istituto di Ricovero e Cura a Carattere Scientifico Istituto 
      Auxologico Italiano, Milan, Italy.
FAU - Bernini, Franco
AU  - Bernini F
AD  - Department of Food and Drug, University of Parma, Parma, Italy.
FAU - Caruso, Donatella
AU  - Caruso D
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Milan, Italy.
FAU - Corsini, Alberto
AU  - Corsini A
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Milan, Italy.
AD  - Multimedica Istituto di Ricovero e Cura a Carattere Scientifico, Milano, Italy.
FAU - Sirtori, Cesare R
AU  - Sirtori CR
AD  - Centro Dislipidemie, Azienda Socio Sanitaria Territoriale Grande Ospedale 
      Metropolitano Niguarda, Milan, Italy.
FAU - Cariboni, Anna
AU  - Cariboni A
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Milan, Italy.
FAU - Bonomi, Marco
AU  - Bonomi M
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Milan, Italy.
AD  - Laboratory of Endocrine and Metabolic Research and Division of Endocrine and 
      Metabolic Diseases, Istituto di Ricovero e Cura a Carattere Scientifico Istituto 
      Auxologico Italiano, Milan, Italy.
FAU - Ruscica, Massimiliano
AU  - Ruscica M
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (ABCA1 protein, human)
RN  - 0 (ABCG1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter 1)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (Cholesterol, HDL)
RN  - 3XMK78S47O (Testosterone)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - ATP Binding Cassette Transporter 1/physiology
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1/physiology
MH  - Adult
MH  - Cardiovascular Diseases/*etiology
MH  - Cholesterol/metabolism
MH  - Cholesterol, HDL/blood/*physiology
MH  - Humans
MH  - Hypogonadism/complications/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Testosterone/blood
EDAT- 2019/03/06 06:00
MHDA- 2020/05/21 06:00
CRDT- 2019/03/06 06:00
PHST- 2018/09/19 00:00 [received]
PHST- 2019/02/26 00:00 [accepted]
PHST- 2019/03/06 06:00 [pubmed]
PHST- 2020/05/21 06:00 [medline]
PHST- 2019/03/06 06:00 [entrez]
AID - 5368424 [pii]
AID - 10.1210/jc.2018-02027 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2019 Aug 1;104(8):3097-3107. doi: 10.1210/jc.2018-02027.