PMID- 30835646
OWN - NLM
STAT- MEDLINE
DCOM- 20190819
LR  - 20190819
IS  - 1557-8976 (Electronic)
IS  - 0882-8245 (Linking)
VI  - 32
IP  - 3
DP  - 2019 Apr
TI  - HLA-A, -B, -DRB1 Alleles as Genetic Predictive Factors for Dengue Disease: A 
      Systematic Review and Meta-Analysis.
PG  - 121-130
LID - 10.1089/vim.2018.0151 [doi]
AB  - Dengue virus infection (DEN) is one of the most prevalent arbovirus diseases in 
      the tropical and subtropical areas. Some human leukocyte antigen (HLA) alleles 
      have been reported to be a protective or risk factor to DEN. Due to the limited 
      sample sizes and regional limitations, the results of individual studies were 
      various. This meta-analysis aimed at investigating the relationship between HLA 
      alleles and dengue disease. Relevant studies of the relationship between HLA and 
      dengue disease were searched through PubMed, Embase, Web of science, and Cochrane 
      databases. Subgroups according to ethnicity or sub-alleles and sensitivity 
      analysis were used to explore the potential source of heterogeneity, which was 
      performed to confirm the findings. The relationships between HLA and dengue 
      disease were defined by odds ratios (ORs) with a 95% confidence interval (CI). 
      Fourteen studies were finally confirmed. Results indicated that A*0203 
      (OR = 2.19, 95% CI = 1.30-3.69) and A*24 in the Asian group (OR = 1.44, 95% 
      CI = 1.21-1.71) were positively associated with an increased risk of DEN when 
      compared with normal controls. A*33 (OR = 0.49, 95% CI = 0.34-0.69) in Southeast 
      Asia was negatively associated with DEN when compared with normal controls, 
      suggesting a protective role against DEN. In addition, DRB1*11 (OR = 4.10, 95% 
      CI = 1.23-13.69) was positively associated with severe dengue (SD) when compared 
      with dengue fever, whereas DRB1*03 (OR = 0.48, 95% CI = 0.28-0.82) and DRB1*09 
      (OR = 0.73, 95% CI = 0.55-0.96) were negatively associated with SD when compared 
      with normal controls. The meta-analysis confirmed that HLA-A*0203, A*24, A*33, 
      DRB1*03, DRB1*09, and DRB1*11 have significantly affected dengue disease, and the 
      associations are related to race and regions.
FAU - Chen, Yuan
AU  - Chen Y
AD  - 1 Department of Clinical Laboratory Medicine, The First Affiliated Hospital of 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Liao, Yingyin
AU  - Liao Y
AD  - 2 KingMed School of Laboratory Medicine of Guangzhou Medical University, 
      Guangzhou, China.
FAU - Yuan, Kangzhuang
AU  - Yuan K
AD  - 1 Department of Clinical Laboratory Medicine, The First Affiliated Hospital of 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Wu, Aiwu
AU  - Wu A
AD  - 2 KingMed School of Laboratory Medicine of Guangzhou Medical University, 
      Guangzhou, China.
FAU - Liu, Lidong
AU  - Liu L
AD  - 1 Department of Clinical Laboratory Medicine, The First Affiliated Hospital of 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20190305
PL  - United States
TA  - Viral Immunol
JT  - Viral immunology
JID - 8801552
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
MH  - Alleles
MH  - Case-Control Studies
MH  - Dengue/*genetics
MH  - Dengue Virus/genetics
MH  - *Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Risk Factors
MH  - Severe Dengue/genetics
OTO - NOTNLM
OT  - dengue virus infection
OT  - genetic susceptibility
OT  - human leukocyte antigen
OT  - meta-analysis
EDAT- 2019/03/06 06:00
MHDA- 2019/08/20 06:00
CRDT- 2019/03/06 06:00
PHST- 2019/03/06 06:00 [pubmed]
PHST- 2019/08/20 06:00 [medline]
PHST- 2019/03/06 06:00 [entrez]
AID - 10.1089/vim.2018.0151 [doi]
PST - ppublish
SO  - Viral Immunol. 2019 Apr;32(3):121-130. doi: 10.1089/vim.2018.0151. Epub 2019 Mar 
      5.