PMID- 30836165
OWN - NLM
STAT- MEDLINE
DCOM- 20210804
LR  - 20210804
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 110
IP  - 1
DP  - 2021 May 1
TI  - Biological Principles of Stereotactic Body Radiation Therapy (SBRT) and 
      Stereotactic Radiation Surgery (SRS): Indirect Cell Death.
PG  - 21-34
LID - S0360-3016(19)30291-3 [pii]
LID - 10.1016/j.ijrobp.2019.02.047 [doi]
AB  - PURPOSE: To review the radiobiological mechanisms of stereotactic body radiation 
      therapy stereotactic body radiation therapy (SBRT) and stereotactic radiation 
      surgery (SRS). METHODS AND MATERIALS: We reviewed previous reports and recent 
      observations on the effects of high-dose irradiation on tumor cell survival, 
      tumor vasculature, and antitumor immunity. We then assessed the potential 
      implications of these biological changes associated with SBRT and SRS. RESULTS: 
      Irradiation with doses higher than approximately 10 Gy/fraction causes 
      significant vascular injury in tumors, leading to secondary tumor cell death. 
      Irradiation of tumors with high doses has also been reported to increase the 
      antitumor immunity, and various approaches are being investigated to further 
      elevate antitumor immunity. The mechanism of normal tissue damage by high-dose 
      irradiation needs to be further investigated. CONCLUSIONS: In addition to 
      directly killing tumor cells, high-dose irradiation used in SBRT and SRS induces 
      indirect tumor cell death via vascular damage and antitumor immunity. Further 
      studies are warranted to better understand the biological mechanisms underlying 
      the high efficacy of clinical SBRT and SRS and to further improve the efficacy of 
      SBRT and SRS.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Song, Chang W
AU  - Song CW
AD  - Department of Radiation Oncology, University of Minnesota Medical School, 
      Minneapolis, Minnesota. Electronic address: songx001@umn.edu.
FAU - Glatstein, Eli
AU  - Glatstein E
AD  - Department of Radiation Oncology, University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Marks, Lawrence B
AU  - Marks LB
AD  - Department of Radiation Oncology, University of North Carolina, Chapel Hill, 
      North Carolina.
FAU - Emami, Bahman
AU  - Emami B
AD  - Department of Radiation Oncology, Loyola University Medical Center, Chicago, 
      Illinois.
FAU - Grimm, Jimm
AU  - Grimm J
AD  - Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins 
      University, Baltimore, Maryland.
FAU - Sperduto, Paul W
AU  - Sperduto PW
AD  - Minneapolis Radiation Oncology and Gamma Knife Center, University of Minnesota, 
      Minneapolis, Minnesota.
FAU - Kim, Mi-Sook
AU  - Kim MS
AD  - Department of Radiation Oncology, Korea Institute of Radiological & Medical 
      Sciences, Seoul, Korea.
FAU - Hui, Susanta
AU  - Hui S
AD  - Department of Radiation Oncology, University of Minnesota Medical School, 
      Minneapolis, Minnesota.
FAU - Dusenbery, Kathryn E
AU  - Dusenbery KE
AD  - Department of Radiation Oncology, University of Minnesota Medical School, 
      Minneapolis, Minnesota.
FAU - Cho, L Chinsoo
AU  - Cho LC
AD  - Department of Radiation Oncology, University of Minnesota Medical School, 
      Minneapolis, Minnesota.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190302
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
CIN - Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):252-253. PMID: 33243480
CIN - Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):251-252. PMID: 33243481
CIN - Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):253-254. PMID: 33864825
MH  - Animals
MH  - Blood Vessels/pathology/radiation effects
MH  - Carcinoma 256, Walker/blood supply/pathology/radiotherapy
MH  - *Cell Death/genetics
MH  - Cell Survival/radiation effects
MH  - DNA Damage
MH  - Dose Fractionation, Radiation
MH  - Endothelium, Vascular/cytology
MH  - Humans
MH  - Immunogenic Cell Death
MH  - Mice
MH  - Mice, Nude
MH  - Neoplasms/blood supply/immunology/*radiotherapy
MH  - Organs at Risk/blood supply/radiation effects
MH  - Radiobiology
MH  - Radiosurgery/*methods
MH  - Rats
MH  - Tumor Hypoxia/radiation effects
MH  - Xenograft Model Antitumor Assays
EDAT- 2019/03/06 06:00
MHDA- 2021/08/05 06:00
CRDT- 2019/03/06 06:00
PHST- 2019/02/13 00:00 [received]
PHST- 2019/02/13 00:00 [revised]
PHST- 2019/02/14 00:00 [accepted]
PHST- 2019/03/06 06:00 [pubmed]
PHST- 2021/08/05 06:00 [medline]
PHST- 2019/03/06 06:00 [entrez]
AID - S0360-3016(19)30291-3 [pii]
AID - 10.1016/j.ijrobp.2019.02.047 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):21-34. doi: 
      10.1016/j.ijrobp.2019.02.047. Epub 2019 Mar 2.